F
François Rustenburg
Researcher at VU University Medical Center
Publications - 21
Citations - 2384
François Rustenburg is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Gene expression profiling & Rheumatoid arthritis. The author has an hindex of 16, co-authored 21 publications receiving 1921 citations. Previous affiliations of François Rustenburg include VU University Amsterdam.
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Journal ArticleDOI
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics
Myron G. Best,Nik Sol,Irsan E. Kooi,Jihane Tannous,Bart A. Westerman,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Jan Koster,Bauke Ylstra,Najim Ameziane,Josephine C. Dorsman,Egbert F. Smit,Henk M.W. Verheul,David P. Noske,Jaap C. Reijneveld,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Bakhos A. Tannous,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger +23 more
TL;DR: The results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based “liquid biopsies”.
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DNA copy number analysis of fresh and formalin-fixed specimens by shallow whole-genome sequencing with identification and exclusion of problematic regions in the genome assembly
Ilari Scheinin,Daoud Sie,Henrik Bengtsson,Mark A. van de Wiel,Adam B. Olshen,Hinke F. van Thuijl,Hendrik F. van Essen,Paul P. Eijk,François Rustenburg,Gerrit A. Meijer,Jaap C. Reijneveld,Pieter Wesseling,Daniel Pinkel,Donna G. Albertson,Bauke Ylstra +14 more
TL;DR: This work improves on previous methods by first implementing a combined correction for sequence mappability and GC content, and second, by applying this procedure to sequence data from the 1000 Genomes Project in order to develop a blacklist of problematic genome regions.
Journal ArticleDOI
Rheumatoid Arthritis subtypes identified by genomic profiling of peripheral blood cells: Assignment of a type I interferon signature in a subpopulation of patients
T C T M van der Pouw Kraan,Carla A. Wijbrandts,L G M van Baarsen,Alexandre E Voskuyl,François Rustenburg,J.M. Baggen,Saleh M. Ibrahim,Michael J. Fero,B A C Dijkmans,Paul P. Tak,Cornelis L. Verweij +10 more
TL;DR: The IFN type I signature defines a subgroup of patients with RA, with a distinct biomolecular phenotype, characterised by increased activity of the innate defence system, coagulation and complement cascades, and fatty acid metabolism.
Journal ArticleDOI
Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets
Myron G. Best,Nik Sol,Sjors G J G In 't Veld,Adrienne Vancura,Mirte Muller,Anna Larissa N. Niemeijer,Aniko V. Fejes,Aniko V. Fejes,Lee Ann Tjon Kon Fat,Anna E. Huis In ‘t Veld,Cyra E. Leurs,Tessa Y S Le Large,Laura L. Meijer,Irsan E. Kooi,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Laurine E. Wedekind,Jillian Bracht,Michelle Esenkbrink,Leon J Wils,Francesca Favaro,Jilian D. Schoonhoven,Jihane Tannous,Hanne Meijers-Heijboer,Geert Kazemier,Elisa Giovannetti,Jaap C. Reijneveld,Sander Idema,Joep Killestein,Michal Heger,Saskia C.A. de Jager,Rolf T. Urbanus,Imo E. Hoefer,Gerard Pasterkamp,Christine Mannhalter,Jose Gomez-Arroyo,Harm Jan Bogaard,David P. Noske,W. Peter Vandertop,Daan van den Broek,Bauke Ylstra,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Pieter Wesseling,Pieter Wesseling,Niki Karachaliou,Rafael Rosell,Elizabeth Lee-Lewandrowski,Kent B. Lewandrowski,Bakhos A. Tannous,Adrianus J. de Langen,Egbert F. Smit,Egbert F. Smit,Michel M van den Heuvel,Michel M van den Heuvel,Thomas Wurdinger,Thomas Wurdinger +58 more
TL;DR: It is demonstrated that particle-swarm optimization-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.
Journal ArticleDOI
Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment
Lisa G. M. van Baarsen,Lisa G. M. van Baarsen,Carla A. Wijbrandts,François Rustenburg,Tineke Cantaert,Tineke C. T. M. van der Pouw Kraan,Dominique Baeten,Ben A. C. Dijkmans,Paul P. Tak,Cornelis L. Verweij +9 more
TL;DR: In this paper, the effect of TNF blockade in rheumatoid arthritis (RA) on the type I IFN response gene activity in relation to clinical response was determined.