F
Frans van der Ouderaa
Researcher at Leiden University Medical Center
Publications - 26
Citations - 2308
Frans van der Ouderaa is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Population & Randomized controlled trial. The author has an hindex of 17, co-authored 26 publications receiving 2134 citations. Previous affiliations of Frans van der Ouderaa include University of Bedfordshire & Unilever.
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Journal ArticleDOI
Susceptibility of human metabolic phenotypes to dietary modulation.
Cinzia Stella,Bridgette M. Beckwith-Hall,Olivier Cloarec,Elaine Holmes,John C. Lindon,Jonathan Richard Powell,Frans van der Ouderaa,Sheila Bingham,and Amanda J. Cross,Jeremy K. Nicholson +9 more
TL;DR: 1H NMR spectroscopy is applied in combination with multivariate statistical analysis to characterize the effects of three diets: "vegetarian", "low meat", and "high meat" on the metabotype signature of human participants, showing the potential for the routine use of metabonomics in nutritional and epidemiological studies.
Journal ArticleDOI
A Genomewide Association Study of Skin Pigmentation in a South Asian Population
Renee Stokowski,P. V. Krishna Pant,Tony Dadd,Amelia Fereday,David A. Hinds,Carl Jarman,Wendy Filsell,Rebecca S. Ginger,Martin R. Green,Frans van der Ouderaa,David Cox +10 more
TL;DR: This study is the first to interrogate polymorphisms across the genome, to find genetic determinants of the natural variation of skin pigmentation within a human population.
Journal ArticleDOI
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Joris Deelen,Marian Beekman,Hae-Won Uh,Quinta Helmer,Maris Kuningas,Lene Christiansen,Lene Christiansen,Dennis Kremer,Ruud van der Breggen,H. Eka D. Suchiman,Nico Lakenberg,Erik B. van den Akker,Erik B. van den Akker,Willemijn M. Passtoors,Henning Tiemeier,Diana van Heemst,Anton J. N. de Craen,Fernando Rivadeneira,Eco J. C. de Geus,Markus Perola,Frans van der Ouderaa,David A. Gunn,Dorret I. Boomsma,André G. Uitterlinden,André G. Uitterlinden,Kaare Christensen,Cornelia M. van Duijn,Cornelia M. van Duijn,Bastiaan T. Heijmans,Jeanine J. Houwing-Duistermaat,Rudi G. J. Westendorp,P. Eline Slagboom +31 more
TL;DR: The major locus determining familial longevity up to high age as detected by GWAS was marked by rs2075650, which tags the deleterious effects of the ApoE ε4 allele, and no other major longevity locus was found.
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Summary recommendations for standardization and reporting of metabolic analyses.
John C. Lindon,Jeremy K. Nicholson,Elaine Holmes,Hector C. Keun,Andrew Craig,Jake T M Pearce,Stephen J. Bruce,Nigel Hardy,Susanna-Assunta Sansone,Henrik Antti,Pär Jonsson,Clare A. Daykin,Mahendra Navarange,Richard D. Beger,Elwin Verheij,Alexander Amberg,Dorrit Baunsgaard,Glenn H. Cantor,Lois D. Lehman-McKeeman,Mark Earll,Svante Wold,Erik Johansson,John N. Haselden,Kerstin Kramer,Craig E. Thomas,Johann Lindberg,Ina Schuppe-Koistinen,Ian D. Wilson,Michael D. Reily,Donald G. Robertson,Hans Senn,Arno Krotzky,Sunil Kochhar,Jonathan J. Powell,Frans van der Ouderaa,Robert S. Plumb,Hartmut Schaefer,Manfred Spraul +37 more
TL;DR: The Standard Metabolic Reporting Structures (SMRS) working group outlines its vision for an open, community-driven specification for the standardization and reporting of metabolic studies.
Journal ArticleDOI
Why Some Women Look Young for Their Age
David A. Gunn,Helle Rexbye,Christopher E.M. Griffiths,Peter Murray,Amelia Fereday,Sharon D. Catt,Cyrena C. Tomlin,Barbara H. Strongitharm,Dave I. Perrett,Michael Catt,Andrew E. Mayes,Andrew G. Messenger,Martin R. Green,Frans van der Ouderaa,James W. Vaupel,Kaare Christensen +15 more
TL;DR: It is indicated that women who look young for their age have large lips, avoid sun-exposure and possess genetic factors that protect against the development of gray hair and skin wrinkles.