M
Maris Kuningas
Researcher at Erasmus University Rotterdam
Publications - 34
Citations - 2154
Maris Kuningas is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 23, co-authored 34 publications receiving 2004 citations. Previous affiliations of Maris Kuningas include University of Tartu & Erasmus University Medical Center.
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Journal ArticleDOI
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Joris Deelen,Marian Beekman,Hae-Won Uh,Quinta Helmer,Maris Kuningas,Lene Christiansen,Lene Christiansen,Dennis Kremer,Ruud van der Breggen,H. Eka D. Suchiman,Nico Lakenberg,Erik B. van den Akker,Erik B. van den Akker,Willemijn M. Passtoors,Henning Tiemeier,Diana van Heemst,Anton J. N. de Craen,Fernando Rivadeneira,Eco J. C. de Geus,Markus Perola,Frans van der Ouderaa,David A. Gunn,Dorret I. Boomsma,André G. Uitterlinden,André G. Uitterlinden,Kaare Christensen,Cornelia M. van Duijn,Cornelia M. van Duijn,Bastiaan T. Heijmans,Jeanine J. Houwing-Duistermaat,Rudi G. J. Westendorp,P. Eline Slagboom +31 more
TL;DR: The major locus determining familial longevity up to high age as detected by GWAS was marked by rs2075650, which tags the deleterious effects of the ApoE ε4 allele, and no other major longevity locus was found.
Journal ArticleDOI
The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
Tove Fall,Sara Hägg,Sara Hägg,Reedik Mägi,Reedik Mägi,Alexander Ploner,Krista Fischer,Momoko Horikoshi,Momoko Horikoshi,Antti-Pekka Sarin,Gudmar Thorleifsson,Claes Ladenvall,Mart Kals,Maris Kuningas,Harmen H.M. Draisma,Janina S. Ried,Natalie R. van Zuydam,Ville Huikari,Massimo Mangino,Emily Sonestedt,Beben Benyamin,Beben Benyamin,Christopher P. Nelson,Christopher P. Nelson,Natalia V. Rivera,Kati Kristiansson,Huei-Yi Shen,Huei-Yi Shen,Aki S. Havulinna,Abbas Dehghan,Louise A. Donnelly,Marika Kaakinen,Marja-Liisa Nuotio,Neil Robertson,Neil Robertson,Renée F.A.G. de Bruijn,M. Arfan Ikram,Najaf Amin,Anthony J. Balmforth,Peter S. Braund,Alex S. F. Doney,Angela Döring,Paul Elliott,Tõnu Esko,Oscar H. Franco,Solveig Gretarsdottir,Anna-Liisa Hartikainen,Kauko Heikkilä,Karl-Heinz Herzig,Hilma Holm,Jouke-Jan Hottenga,Elina Hyppönen,Thomas Illig,Aaron Isaacs,Bo Isomaa,Lennart C. Karssen,Johannes Kettunen,Johannes Kettunen,Wolfgang Koenig,Kari Kuulasmaa,Tiina Laatikainen,Jaana Laitinen,Cecilia M. Lindgren,Valeriya Lyssenko,Valeriya Lyssenko,Esa Läärä,Nigel W. Rayner,Nigel W. Rayner,Nigel W. Rayner,Satu Männistö,Anneli Pouta,Anneli Pouta,Wolfgang Rathmann,Fernando Rivadeneira,Aimo Ruokonen,Markku J. Savolainen,Eric J.G. Sijbrands,Kerrin S. Small,Jan Smit,Valgerdur Steinthorsdottir,Ann-Christine Syvänen,Anja Taanila,Martin D. Tobin,André G. Uitterlinden,Sara M. Willems,Gonneke Willemsen,Jacqueline C.M. Witteman,Markus Perola,Markus Perola,Alun Evans,Jean Ferrières,Jarmo Virtamo,Frank Kee,David-Alexandre Trégouët,Dominique Arveiler,Philippe Amouyel,Marco M Ferrario,Paolo Brambilla,Alistair S. Hall,Andrew C. Heath,Pamela A. F. Madden,Nicholas G. Martin,Grant W. Montgomery,John Whitfield,Antti Jula,Paul Knekt,Ben A. Oostra,Cornelia M. van Duijn,Brenda W.J.H. Penninx,George Davey Smith,Jaakko Kaprio,Jaakko Kaprio,Nilesh J. Samani,Nilesh J. Samani,Christian Gieger,Annette Peters,H.-Erich Wichmann,Dorret I. Boomsma,Eco J. C. de Geus,Tiinamaija Tuomi,Chris Power,Christopher J Hammond,Tim D. Spector,Lars Lind,Marju Orho-Melander,Colin N. A. Palmer,Andrew D. Morris,Leif Groop,Leif Groop,Marjo-Riitta Järvelin,Veikko Salomaa,Erkki Vartiainen,Albert Hofman,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Andres Metspalu,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Nancy L. Pedersen,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Erik Ingelsson,Erik Ingelsson,Erik Ingelsson,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko +150 more
TL;DR: In this study, Prokopenko and colleagues provide novel evidence for causal relationship between adiposity and heart failure and increased liver enzymes using a Mendelian randomization study design.
Journal ArticleDOI
A Genome-Wide Association Study of Depressive Symptoms
Karin Hek,Ayse Demirkan,Jari Lahti,Jari Lahti,Antonio Terracciano,Alexander Teumer,Marilyn C. Cornelis,Najaf Amin,Erin Bakshis,Jens Baumert,Jingzhong Ding,Yongmei Liu,Kristin D. Marciante,Osorio Meirelles,Mike A. Nalls,Yan V. Sun,Nicole Vogelzangs,Lei Yu,Stefania Bandinelli,Emelia J. Benjamin,David A. Bennett,Dorret I. Boomsma,Alessandra Cannas,Laura H. Coker,Eco J. C. de Geus,Philip L. De Jager,Ana V. Diez-Roux,Shaun Purcell,Frank B. Hu,Eric B. Rimm,David J. Hunter,Majken K. Jensen,Gary C. Curhan,Kenneth Rice,Alan D. Penman,Jerome I. Rotter,Nona Sotoodehnia,Rebecca T. Emeny,Johan G. Eriksson,Denis A. Evans,Luigi Ferrucci,Myriam Fornage,Vilmundur Gudnason,Albert Hofman,Thomas Illig,Sharon L.R. Kardia,Margaret Kelly-Hayes,Karestan C. Koenen,Peter Kraft,Maris Kuningas,Joseph M. Massaro,David Melzer,Antonella Mulas,Cornelis L. Mulder,Anna Murray,Ben A. Oostra,Aarno Palotie,Brenda W.J.H. Penninx,Astrid Petersmann,Luke C. Pilling,Bruce M. Psaty,Rajesh Rawal,Eric M. Reiman,Andrea Schulz,Joshua M. Shulman,Andrew B. Singleton,Albert V. Smith,Angelina R. Sutin,Angelina R. Sutin,André G. Uitterlinden,Henry Völzke,Elisabeth Widen,Kristine Yaffe,Alan B. Zonderman,Francesco Cucca,Tamara B. Harris,Karl-Heinz Ladwig,David J. Llewellyn,Katri Räikkönen,Toshiko Tanaka,Cornelia M. van Duijn,Hans J. Grabe,Lenore J. Launer,Kathryn L. Lunetta,Thomas H. Mosley,Anne B. Newman,Henning Tiemeier,Joanne M. Murabito +87 more
TL;DR: The results suggest that only a large sample comprising more than 50,000 subjects may be sufficiently powered to detect genes for depressive symptoms, as well as a combined meta-analysis of all 22 discovery and replication studies.
Journal ArticleDOI
A genome-wide association study of aging
Stefan Walter,Gil Atzmon,Ellen W. Demerath,Melissa E. Garcia,Robert C. Kaplan,Meena Kumari,Kathryn L. Lunetta,Yuri Milaneschi,Toshiko Tanaka,Gregory J. Tranah,Uwe Völker,Lei Yu,Alice M. Arnold,Emelia J. Benjamin,Emelia J. Benjamin,Reiner Biffar,Aron S. Buchman,Eric Boerwinkle,David Couper,Philip L. De Jager,Denis A. Evans,Tamara B. Harris,Wolfgang Hoffmann,Wolfgang Hoffmann,Albert Hofman,David Karasik,Douglas P. Kiel,Thomas Kocher,Maris Kuningas,Lenore J. Launer,Kurt Lohman,Pamela L. Lutsey,Johan P. Mackenbach,Kristin D. Marciante,Bruce M. Psaty,Bruce M. Psaty,Eric M. Reiman,Jerome I. Rotter,Sudha Seshadri,Sudha Seshadri,Michelle Shardell,Albert V. Smith,Cornelia M. van Duijn,Jeremy D. Walston,M. Carola Zillikens,Stefania Bandinelli,Sebastian E. Baumeister,David A. Bennett,Luigi Ferrucci,Vilmundur Gudnason,Mika Kivimäki,Yongmei Liu,Joanne M. Murabito,Joanne M. Murabito,Anne B. Newman,Henning Tiemeier,Nora Franceschini +56 more
TL;DR: Findings indicate that variation in genes involved in neurological processes may be an important factor in regulating aging free of major disease and achieving longevity.
Journal ArticleDOI
VDR gene variants associate with cognitive function and depressive symptoms in old age.
Maris Kuningas,Maris Kuningas,Simon P. Mooijaart,Jelle Jolles,P. Eline Slagboom,Rudi G. J. Westendorp,Diana van Heemst +6 more
TL;DR: The results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms.