F
Fred Kironde
Researcher at Islamic University in Uganda
Publications - 61
Citations - 2411
Fred Kironde is an academic researcher from Islamic University in Uganda. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 26, co-authored 60 publications receiving 2214 citations. Previous affiliations of Fred Kironde include St. Augustine International University & San Francisco General Hospital.
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Journal ArticleDOI
Polymorphisms in Plasmodium falciparum chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine
Meera Venkatesan,Nahla B Gadalla,Kasia Stepniewska,Prabin Dahal,Christian Nsanzabana,Clarissa Moriera,Ric N. Price,Andreas Mårtensson,Philip J. Rosenthal,Grant Dorsey,Colin J. Sutherland,Philippe J Guerin,Timothy M. E. Davis,Didier Menard,Ishag Adam,George O. Ademowo,Cesar Arze,Frederick N. Baliraine,Nicole Berens-Riha,Anders Björkman,Steffen Borrmann,Francesco Checchi,Meghna Desai,Mehul Dhorda,Abdoulaye Djimde,Badria B. El-Sayed,Teferi Eshetu,Frederick Eyase,Catherine O. Falade,Jean-François Faucher,Gabrielle Fröberg,Anastasia Grivoyannis,Sally Hamour,Sandrine Houzé,Jacob D. Johnson,Erasmus Kamugisha,Simon Kariuki,Jean-René Kiechel,Fred Kironde,Fred Kironde,Poul-Erik Kofoed,Jacques Lebras,Maja Malmberg,Maja Malmberg,Leah Mwai,Leah Mwai,Billy Ngasala,François Nosten,Samuel L. Nsobya,Alexis Nzila,Alexis Nzila,Mary C. Oguike,Sabina Dahlström Otienoburu,Bernhards Ogutu,Jean-Bosco Ouédraogo,Patrice Piola,Patrice Piola,Lars Rombo,Birgit Schramm,A. Fabrice Some,Julie Thwing,Johan Ursing,Rina P. M. Wong,Ahmed Zeynudin,Issaka Zongo,Christopher V. Plowe,Carol Hopkins Sibley,Carol Hopkins Sibley +67 more
TL;DR: Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine.
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A molecular link between malaria and Epstein-Barr virus reactivation.
Arnaud Chêne,Daria Donati,André Ortlieb Guerreiro-Cacais,Victor Levitsky,Qijun Chen,Kerstin I. Falk,Kerstin I. Falk,Jackson Orem,Fred Kironde,Mats Wahlgren,Mats Wahlgren,Maria Teresa Bejarano +11 more
TL;DR: This is the first report to show that a microbial protein can drive a latently infected B cell into EBV replication and suggest that P. falciparum antigens such as CIDR1α can directly induce EBV reactivation during malaria infection that may increase the risk of BL development for children living in malaria-endemic areas.
Journal ArticleDOI
Heparan sulfate on endothelial cells mediates the binding of Plasmodium falciparum-infected erythrocytes via the DBL1alpha domain of PfEMP1.
TL;DR: HS and the previously identified HS-like GAG on uninfected erythrocytes may act as coreceptors in endothelial and ERYthrocyte binding of rosetting parasites, causing excessive sequestration of both pRBCs and RBCs.
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Artemisinin versus Nonartemisinin Combination Therapy for Uncomplicated Malaria: Randomized Clinical Trials from Four Sites in Uganda
Adoke Yeka,Kristin Banek,Nathan Bakyaita,Sarah G. Staedke,Moses R. Kamya,Ambrose Talisuna,Fred Kironde,Samuel L. Nsobya,Albert Kilian,Madeline Slater,Arthur Reingold,Philip J. Rosenthal,Fred Wabwire-Mangen,Grant Dorsey +13 more
TL;DR: A AQ + AS was the most efficacious regimen for preventing recrudescence, but this benefit was outweighed by an increased risk of new infection.
Journal ArticleDOI
PfEMP1-DBL1α amino acid motifs in severe disease states of Plasmodium falciparum malaria
Johan Normark,Daniel Nilsson,Ulf Ribacke,Gerhard Winter,Kirsten Moll,Craig E. Wheelock,Justus Bayarugaba,Fred Kironde,Thomas G. Egwang,Qijun Chen,Björn Andersson,Mats Wahlgren +11 more
TL;DR: It is suggested that certain PfEMP1 sequences are predisposed to inducing severe malaria through var-specific DBL1α-PCR amplification and sequencing.