F
Frederic Geissmann
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 153
Citations - 43031
Frederic Geissmann is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Monocyte & Macrophage. The author has an hindex of 73, co-authored 147 publications receiving 37781 citations. Previous affiliations of Frederic Geissmann include New York University & University of Paris.
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Journal ArticleDOI
Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet.
Katie J. Woodcock,Katrin Kierdorf,Clara A. Pouchelon,Valérie Vivancos,Marc Dionne,Frederic Geissmann +5 more
TL;DR: An evolutionarily conserved “scavenger receptor-JNK-type 1 cytokine” cassette in macrophages is identified, which controls glucose metabolism and reduces lifespan in Drosophila maintained on a lipid-rich diet via activation of the JAK-STAT pathway.
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A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease
Elvira Mass,Christian E. Jacome-Galarza,Thomas Blank,Tomi Lazarov,Benjamin H. Durham,Neval Ozkaya,Alessandro Pastore,Marius Schwabenland,Young Rock Chung,Marc K. Rosenblum,Marco Prinz,Omar Abdel-Wahab,Frederic Geissmann,Frederic Geissmann +13 more
TL;DR: It is shown that mosaic expression of BRAF(V600E) in mouse EMPs results in clonal expansion of tissue-resident macrophages and a severe late-onset neurodegenerative disorder, which is associated with accumulation of ERK-activated amoeboid microglia in mice and is also observed in human patients with histiocytoses.
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Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke
Yves Werner,Elvira Mass,Elvira Mass,Praveen Ashok Kumar,Thomas Ulas,Thomas Ulas,Kristian Händler,Kristian Händler,Arik Horne,Kathrin Klee,Amelie Lupp,Dagmar Schütz,Friederike Saaber,Christoph Redecker,Joachim L. Schultze,Joachim L. Schultze,Frederic Geissmann,Ralf Stumm +17 more
TL;DR: Cxcr4 -CreER enables permanent genetic labeling of hematopoietic stem cells (HSCs) and distinguishes HSC-derived monocytes from microglia and other tissue-resident macrophages and is proposed as a universal tool to study functions of H SC-derived cells.
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Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb
Martin Etzrodt,Virna Cortez-Retamozo,Andita Newton,Jimmy L. Zhao,Aylwin Ng,Moritz Wildgruber,Pedro Romero,Thomas Wurdinger,Ramnik J. Xavier,Frederic Geissmann,Etienne Meylan,Matthias Nahrendorf,Filip K. Swirski,David Baltimore,Ralph Weissleder,Mikael J. Pittet +15 more
TL;DR: In this article, a microRNA (miRNA), miR-146a, was found to be differentially regulated both in mouse (Ly-6C^(hi)/ Ly-6c^(lo)) and human (CD14^ (hi)/CD14-lo)CD16^+) monocyte subsets.
Journal ArticleDOI
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms
Benjamin H. Durham,Estibaliz Lopez Rodrigo,Jennifer Picarsic,Jennifer Picarsic,David H. Abramson,Veronica Rotemberg,Steven De Munck,Erwin Pannecoucke,Sydney X. Lu,Alessandro Pastore,Akihide Yoshimi,Diana Mandelker,Ozge Ceyhan-Birsoy,Gary A. Ulaner,Michael Walsh,Mariko Yabe,Kseniya Petrova-Drus,Maria E. Arcila,Marc Ladanyi,David B. Solit,Michael F. Berger,David M. Hyman,Mario E. Lacouture,Caroline Erickson,Ruth Saganty,Michelle Ki,Ira J. Dunkel,Vicente Santa-María López,Jaume Mora,Julien Haroche,Jean-François Emile,Olivier Decaux,Frederic Geissmann,Savvas N. Savvides,Alexander Drilon,Eli L. Diamond,Omar Abdel-Wahab +36 more
TL;DR: This study uncovered activating mutations in CSF1R and rearrangements in RET and ALK that conferred dramatic responses to selective inhibition of RET (selpercatinib) and crizotinib, respectively, in patients with histiocytosis.