F
Frederic Geissmann
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 153
Citations - 43031
Frederic Geissmann is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Monocyte & Macrophage. The author has an hindex of 73, co-authored 147 publications receiving 37781 citations. Previous affiliations of Frederic Geissmann include New York University & University of Paris.
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Journal ArticleDOI
Origin, fate and dynamics of macrophages at central nervous system interfaces.
Tobias Goldmann,Peter Wieghofer,Marta Joana Costa Jordão,Fabiola Prutek,Nora Hagemeyer,Kathrin Frenzel,Lukas Amann,Ori Staszewski,Katrin Kierdorf,Martin Krueger,Giuseppe Locatelli,Hannah Hochgerner,Robert Zeiser,Slava Epelman,Frederic Geissmann,Josef Priller,Fabio M.V. Rossi,Ingo Bechmann,Martin Kerschensteiner,Sten Linnarsson,Steffen Jung,Marco Prinz +21 more
TL;DR: Using parabiosis and fate-mapping approaches in mice, it is found that CNS macrophages arose from hematopoietic precursors during embryonic development and established stable populations, with the notable exception of choroid plexus macrophage, which had dual origins and a shorter life span.
Journal ArticleDOI
X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling.
Rainer Doffinger,Asma Smahi,Christine Bessia,Frederic Geissmann,Jacqueline Feinberg,Anne Durandy,Christine Bodemer,Sue Kenwrick,Sophie Dupuis-Girod,Stéphane Blanche,Philip A. Wood,Smail Hadj Rabia,Denis J. Headon,Paul A. Overbeek,Françoise Le Deist,Steven M. Holland,Kiran Belani,Dinakantha S. Kumararatne,Alain Fischer,Ralph S. Shapiro,Mary Ellen Conley,Eric Reimund,Hermann Kalhoff,Mario Abinun,Arnold Munnich,Alain Israël,Gilles Courtois,Jean-Laurent Casanova +27 more
TL;DR: It is reported for the first time that impaired but not abolished NF-κB signaling in humans results in two related syndromes that associate specific developmental and immunological defects.
Journal ArticleDOI
Herpes simplex virus encephalitis in human UNC-93B deficiency.
Armanda Casrouge,Shen-Ying Zhang,Shen-Ying Zhang,Celine Eidenschenk,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Anne Puel,Kun Yang,Kun Yang,Alexandre Alcaïs,Capucine Picard,Nora Mahfoufi,Nathalie Nicolas,Lazaro Lorenzo,Sabine Plancoulaine,Brigitte Senechal,Frederic Geissmann,Koichi Tabeta,Koichi Tabeta,Kasper Hoebe,Xin Du,Richard L. Miller,Bénédicte Héron,Cyril Mignot,Thierry Billette de Villemeur,Pierre Lebon,Olivier Dulac,Flore Rozenberg,Bruce Beutler,Marc Tardieu,Laurent Abel,Jean-Laurent Casanova,Jean-Laurent Casanova +32 more
TL;DR: A genetic etiology for HSE is elucidated in two children with autosomal recessive deficiency in the intracellular protein UNC-93B, resulting in impaired cellular interferon-α/β and -λ antiviral responses.
Journal ArticleDOI
Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids.
Frederic Geissmann,Thomas O. Cameron,Stephane Sidobre,Natasha Manlongat,Mitchell Kronenberg,Michael J. Briskin,Michael L. Dustin,Dan R. Littman +7 more
TL;DR: NKT cells patrol liver sinusoids to provide intravascular immune surveillance, and CXCR6 contributes to liver-based immune responses by regulating their abundance.
Journal ArticleDOI
Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal.
Leo M. Carlin,Efstathios G. Stamatiades,Cédric Auffray,Richard N. Hanna,Leanne Glover,Gema Vizcay-Barrena,Catherine C. Hedrick,H. Terence Cook,Sandra S. Diebold,Frederic Geissmann,Frederic Geissmann +10 more
TL;DR: Ly6Clow monocytes are intravascular housekeepers that orchestrate the necrosis by neutrophils of endothelial cells that signal a local threat sensed via TLR7 followed by the in situ phagocytosis of cellular debris.