Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb
Martin Etzrodt,Virna Cortez-Retamozo,Andita Newton,Jimmy L. Zhao,Aylwin Ng,Moritz Wildgruber,Pedro Romero,Thomas Wurdinger,Ramnik J. Xavier,Frederic Geissmann,Etienne Meylan,Matthias Nahrendorf,Filip K. Swirski,David Baltimore,Ralph Weissleder,Mikael J. Pittet +15 more
TLDR
In this article, a microRNA (miRNA), miR-146a, was found to be differentially regulated both in mouse (Ly-6C^(hi)/ Ly-6c^(lo)) and human (CD14^ (hi)/CD14-lo)CD16^+) monocyte subsets.About:
This article is published in Cell Reports.The article was published on 2012-04-19 and is currently open access. It has received 103 citations till now. The article focuses on the topics: Monocyte & RELB.read more
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The M1 and M2 paradigm of macrophage activation: time for reassessment.
TL;DR: How cytokines and pathogen signals influence macrophages' functional phenotypes and the evidence for M1 and M2 functions is assessed and a paradigm initially based on the role of a restricted set of selected ligands in the immune response is revisited.
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Monocytes and macrophages: developmental pathways and tissue homeostasis
Florent Ginhoux,Steffen Jung +1 more
TL;DR: The evidence that has dramatically changed the authors' understanding of monocyte and macrophage development, and the maintenance of these cells in the steady state is discussed.
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Resolution of Inflammation: What Controls Its Onset?
TL;DR: It is suggested that several mediators that promote the inflammatory phase of inflammation can simultaneously initiate a program for active resolution and several events enact a decrease in the local chemokine concentration, essential to inhibit further infiltration of neutrophils into the tissue.
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Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
Oleg Butovsky,Shafiuddin Siddiqui,Galina Gabriely,Amanda J. Lanser,Ben Dake,Gopal Murugaiyan,Camille Doykan,Pauline M. Wu,Reddy R. Gali,Lakshmanan K. Iyer,Robert Lawson,James D. Berry,Anna M. Krichevsky,Merit Cudkowicz,Howard L. Weiner +14 more
TL;DR: The results suggest that recruitment of inflammatory monocytes plays an important role in disease progression and that modulation of these cells is a potential therapeutic approach.
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Noncoding RNAs, cytokines, and inflammation-related diseases
José Luiz Marques-Rocha,Mirian Samblas,Fermín I. Milagro,Josefina Bressan,J. Alfredo Martínez,Amelia Marti +5 more
TL;DR: Findings in the field are summarized, highlighting those noncoding RNAs that regulate inflammation, with emphasis on recognized mediators such as TNF‐α, IL‐1,IL‐6, IL-18, intercellular adhesion molecule 1, VCAM‐1 and plasminogen activator inhibitor 1.
References
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Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
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Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian,Jeffrey W. Pollard +1 more
TL;DR: There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression, and specialized subpopulations of macrophage may represent important new therapeutic targets.
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NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
TL;DR: A role is proposed for miR-146 in control of Toll-like receptor and cytokine signaling through a negative feedback regulation loop involving down-regulation of IL-1 receptor-associated kinase 1 and TNF receptor- associated factor 6 protein levels.
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miRBase: integrating microRNA annotation and deep-sequencing data
Ana Kozomara,Sam Griffiths-Jones +1 more
TL;DR: This work has mapped reads from short RNA deep-sequencing experiments to microRNAs in miRBase and developed web interfaces to view these mappings, which can be used as a proxy for relative expression levels of microRNA sequences, provide detailed evidence for microRNA annotations and alternative isoforms of mature micro RNAs, and allow us to revisit previous annotations.
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Development of Monocytes, Macrophages, and Dendritic Cells
TL;DR: The current understanding of myeloid lineage development is reviewed and the developmental pathways and cues that drive differentiation are described, which are central to the development of immunologic memory and tolerance in mice.