F
Frederic Geissmann
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 153
Citations - 43031
Frederic Geissmann is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Monocyte & Macrophage. The author has an hindex of 73, co-authored 147 publications receiving 37781 citations. Previous affiliations of Frederic Geissmann include New York University & University of Paris.
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Journal ArticleDOI
Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells
Charlotta Böiers,Joana Carrelha,Michael Lutteropp,Sidinh Luc,Joanna C. A. Green,Emanuele Azzoni,Petter S. Woll,Adam J. Mead,Anne Hultquist,Gemma Swiers,Elisa Gomez Perdiguero,Iain C. Macaulay,Luca Melchiori,Tiago C. Luis,Shabnam Kharazi,Tiphaine Bouriez-Jones,Qiaolin Deng,Annica Pontén,Deborah Atkinson,Christina Jensen,Ewa Sitnicka,Frederic Geissmann,Isabelle Godin,Rickard Sandberg,Marella F. T. R. de Bruijn,Sten Eirik W. Jacobsen,Sten Eirik W. Jacobsen +26 more
TL;DR: It is demonstrated that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor.
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BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy
Sébastien Héritier,Jean-François Emile,Mohamed-Aziz Barkaoui,Caroline Thomas,Sylvie Fraitag,Sabah Boudjemaa,Florence Renaud,Anne Moreau,Michel Peuchmaur,Catherine Chassagne-Clément,Frédérique Dijoud,Valérie Rigau,Despina Moshous,Anne Lambilliotte,Françoise Mazingue,Kamila Kebaili,Jean Miron,Eric Jeziorski,Geneviève Plat,Nathalie Aladjidi,Alina Ferster,Hélène Pacquement,Claire Galambrun,Laurence Brugières,Guy Leverger,Ludovic Mansuy,Catherine Paillard,Anne Deville,Corinne Armari-Alla,Anne Lutun,Marion Gillibert-Yvert,Jean Louis Stephan,Fleur Cohen-Aubart,Julien Haroche,Isabelle Pellier,Frédéric Millot,Brigitte Lescoeur,Virginie Gandemer,Christine Bodemer,Roger Lacave,Zofia Hélias-Rodzewicz,Valérie Taly,Frederic Geissmann,Jean Donadieu +43 more
TL;DR: In children with LCH, BRAF(V600E) mutation was associated with high-risk features, permanent injury, and poor short-term response to chemotherapy, and the impact of BRAF inhibitors for this subgroup of patients who may benefit from targeted therapy.
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The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells.
Shinelle Menezes,Daisy Melandri,Giorgio Anselmi,Thibaut Perchet,Jakob Loschko,Juan Dubrot,Rajen Patel,Emmanuel L. Gautier,Stéphanie Hugues,M. Paula Longhi,Jake Y. Henry,Sergio A. Quezada,Grégoire Lauvau,Ana-Maria Lennon-Duménil,Enrique Gutiérrez-Martinez,Alain Bessis,Elisa Gomez-Perdiguero,Christian E. Jacome-Galarza,Hannah Garner,Frederic Geissmann,Rachel Golub,Michel C. Nussenzweig,Pierre Guermonprez +22 more
TL;DR: It is shown that naive monocytes are phenotypically heterogeneous and contain an NR4A1- and Flt3L-independent, CCR2-dependent, Flt 3+CD11c−MHCII+PU.1hi subset, which acted as a precursor for FcγRIII+PD-L2+CD209a+, GM-CSF-dependent moDCs but was distal from the DC lineage.
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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.
Mashito Sakai,Ty D. Troutman,Jason S. Seidman,Zhengyu Ouyang,Nathanael J. Spann,Yohei Abe,Kaori M. Ego,Cassi M. Bruni,Zihou Deng,Johannes C. M. Schlachetzki,Alexi Nott,Hunter Bennett,Jonathan Chang,Bao Chau T. Vu,Martina P. Pasillas,Verena M. Link,Verena M. Link,Lorane Texari,Sven Heinz,Bonne M. Thompson,Jeffrey G. McDonald,Frederic Geissmann,Christopher K. Glass +22 more
TL;DR: Analysis of transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer cell depletion provides a framework for understanding how macrophage progenitor cells acquire tissue-specific phenotypes.
Journal ArticleDOI
Macrophages of distinct origins contribute to tumor development in the lung.
Pierre-Louis Loyher,Pierre-Louis Loyher,Pauline Hamon,Marie Laviron,Aïda Meghraoui-Kheddar,Elena Gonçalves,Zihou Deng,Sara Torstensson,Nadège Bercovici,Camille Baudesson de Chanville,Béhazine Combadière,Frederic Geissmann,Ariel Savina,Christophe Combadière,Alexandre Boissonnas +14 more
TL;DR: The results reveal that the developmental origin of TAMs dictates their relative distribution, function, and response to cancer therapies in lung tumors and anti-VEGF treatment combined with chemotherapy inhibited both Res and Mod-TAM reconstitution without affecting monocyte infiltration and improved its efficacy.