F
Fredrik Salmén
Researcher at Royal Institute of Technology
Publications - 25
Citations - 3977
Fredrik Salmén is an academic researcher from Royal Institute of Technology. The author has contributed to research in topics: Gene & Transcriptome. The author has an hindex of 16, co-authored 24 publications receiving 2079 citations. Previous affiliations of Fredrik Salmén include Royal Netherlands Academy of Arts and Sciences & Utrecht University.
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Journal ArticleDOI
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Patrik L. Ståhl,Patrik L. Ståhl,Fredrik Salmén,Sanja Vickovic,Anna Lundmark,Anna Lundmark,José Fernández Navarro,José Fernández Navarro,Jens P. Magnusson,Stefania Giacomello,Michaela Asp,Jakub Orzechowski Westholm,Mikael Huss,Annelie Mollbrink,Sten Linnarsson,Simone Codeluppi,Åke Borg,Fredrik Pontén,Paul I. Costea,Pelin Sahlén,Jan Mulder,Olaf Bergmann,Joakim Lundeberg,Jonas Frisén +23 more
TL;DR: By positioning histological sections on arrayed reverse transcription primers with unique positional barcodes, this work demonstrates high-quality RNA-sequencing data with maintained two-dimensional positional information from the mouse brain and human breast cancer.
Journal ArticleDOI
High-definition spatial transcriptomics for in situ tissue profiling.
Sanja Vickovic,Sanja Vickovic,Gökcen Eraslan,Fredrik Salmén,Johanna Klughammer,Linnea Stenbeck,Denis Schapiro,Denis Schapiro,Tarmo Äijö,Richard Bonneau,Ludvig Bergenstråhle,José Fernández Navarro,Joshua Gould,Gabriel K. Griffin,Gabriel K. Griffin,Åke Borg,Mostafa Ronaghi,Jonas Frisén,Joakim Lundeberg,Joakim Lundeberg,Aviv Regev,Aviv Regev,Patrik L. Ståhl +22 more
TL;DR: High-definition spatial transcriptomics is developed, which captures RNA from histological tissue sections on a dense, spatially barcoded bead array, which opens the way to high-resolution spatial analysis of cells and tissues.
Journal ArticleDOI
A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart
Michaela Asp,Stefania Giacomello,Ludvig Larsson,Chenglin Wu,Daniel Fürth,Xiaoyan Qian,Eva Wärdell,Joaquin Custodio,Johan Reimegård,Fredrik Salmén,Cecilia Österholm,Patrik L. Ståhl,Erik Sundström,Elisabet Åkesson,Olaf Bergmann,Magda Bienko,Agneta Månsson-Broberg,Mats Nilsson,Christer Sylvén,Joakim Lundeberg +19 more
TL;DR: A molecular approach is presented that reveals the comprehensive transcriptional landscape of cell types populating the embryonic heart at three developmental stages and that maps cell-type-specific gene expression to specific anatomical domains.
Journal ArticleDOI
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Emelie Berglund,Jonas Maaskola,Niklas Schultz,Stefanie Friedrich,Maja Marklund,Joseph Bergenstråhle,Firas Tarish,Anna Tanoglidi,Sanja Vickovic,Ludvig Larsson,Fredrik Salmén,Christoph Ogris,Karolina Wallenborg,Jens Lagergren,Patrik L. Ståhl,Erik L. L. Sonnhammer,Thomas Helleday,Joakim Lundeberg +17 more
TL;DR: Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today and here, the authors investigate transcriptional heterogeneity in prostate cancer, examining expression profiles of different tissue components and highlighting expression gradients in the tumor microenvironment.
Journal ArticleDOI
Barcoded solid-phase RNA capture for Spatial Transcriptomics profiling in mammalian tissue sections.
Fredrik Salmén,Fredrik Salmén,Patrik L. Ståhl,Annelie Mollbrink,José Fernández Navarro,Sanja Vickovic,Sanja Vickovic,Jonas Frisén,Joakim Lundeberg +8 more
TL;DR: A protocol describing how to apply the Spatial Transcriptomics technology to mammalian tissue is presented, which combines histological staining and spatially resolved RNA-sequencing data from intact tissue sections.