Gentaro Iribe

TL;DR: Axial stretch of rat cardiomyocytes acutely and transiently increases sarcoplasmic reticulum Ca2+ spark rate via a mechanism that is independent of sarcolemmal stretch-activated ion channels, nitric oxide synthesis, or availability of extracellular calcium but that requires cytoskeletal integrity.

TL;DR: The ability of the present system to independently and dynamically control preload, afterload, and transition between end-diastolic and end-systolic FL coordinates provides a valuable extension to the range of tools available for the study of single cardiomyocyte mechanics, to foster its interrelation with whole heart pathophysiology.

TL;DR: It is demonstrated that cardiac myofibroblasts, which execute tissue fibrosis by producing extracellular matrix proteins, efficiently engulf dead cells in the infarcted area and that following MFG-E8–mediated engulfment of apoptotic cells, myofibiablasts acquired antiinflammatory properties.

TL;DR: A draft standard for recording, annotating, and reporting experimental data, called Minimum Information about a Cardiac Electrophysiology Experiment (MICEE) is presented, with the ultimate goal of developing a useful tool for cardiac electrophysiologists which facilitates and improves dissemination of the minimum information necessary for reproduction of cardiac electrophic research.

TL;DR: The effects of diastolic length changes are investigated axially using a pair of carbon fibres attached to opposite ends of Guinea pig isolated ventricular myocytes to study the availability of Ca2+ in the main cellular stores (the sarcoplasmic reticulum; SR), and Axial stretch enhanced the rate of both rest-decay and reloading of [Ca2+]SR.