G
Georg K. Gerber
Researcher at Brigham and Women's Hospital
Publications - 69
Citations - 9258
Georg K. Gerber is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Microbiome & Population. The author has an hindex of 28, co-authored 66 publications receiving 7919 citations. Previous affiliations of Georg K. Gerber include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Tong Ihn Lee,Nicola J. Rinaldi,François Robert,Duncan T. Odom,Ziv Bar-Joseph,Georg K. Gerber,Nancy M. Hannett,Christopher T. Harbison,Craig M. Thompson,Itamar Simon,Julia Zeitlinger,Ezra G. Jennings,Heather L. Murray,D. Benjamin Gordon,Bing Ren,John J. Wyrick,Jean-Bosco Tagne,Thomas L. Volkert,Ernest Fraenkel,David K. Gifford,Richard A. Young +20 more
TL;DR: This work determines how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells, and identifies network motifs, the simplest units of network architecture, and demonstrates that an automated process can use motifs to assemble a transcriptional regulatory network structure.
Journal ArticleDOI
Alterations of the human gut microbiome in multiple sclerosis
Sushrut Jangi,Roopali Gandhi,Laura M. Cox,Ning Li,Felipe von Glehn,Raymond Yan,Bonny Patel,Maria Antonietta Mazzola,Shirong Liu,B. Glanz,Sandra Cook,Stephanie Tankou,Fiona Stuart,Kirsy Melo,Parham Nejad,Kathleen Smith,Begüm D. Topçuolu,James F. Holden,Pia Kivisäkk,Tanuja Chitnis,Philip L. De Jager,Francisco J. Quintana,Georg K. Gerber,Lynn Bry,Howard L. Weiner +24 more
TL;DR: Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes.
Journal ArticleDOI
Diet dominates host genotype in shaping the murine gut microbiota.
Rachel N. Carmody,Georg K. Gerber,Jesus-Mario Luevano,Daniel M. Gatti,Lisa Somes,Karen L. Svenson,Peter J. Turnbaugh,Peter J. Turnbaugh +7 more
TL;DR: Repeated dietary shifts demonstrated that most changes to the gut microbiota are reversible, while also uncovering bacteria whose abundance depends on prior consumption, emphasizing the dominant role that diet plays in shaping interindividual variations in host-associated microbial communities.
Journal ArticleDOI
Computational discovery of gene modules and regulatory networks.
Ziv Bar-Joseph,Georg K. Gerber,Tong Ihn Lee,Nicola J. Rinaldi,Jane Y Yoo,François Robert,D. Benjamin Gordon,Ernest Fraenkel,Tommi S. Jaakkola,Richard A. Young,David K. Gifford +10 more
TL;DR: An algorithm for discovering regulatory networks of gene modules, GRAM (Genetic Regulatory Modules), that combines information from genome-wide location and expression data sets and explicitly links genes to the factors that regulate them by incorporating DNA binding data, which provide direct physical evidence of regulatory interactions.
Journal ArticleDOI
A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis
Magali Noval Rivas,Oliver T. Burton,Petra Wise,Yu-qian Zhang,Suejy A. Hobson,Maria Garcia Lloret,Christel Chehoud,Justin Kuczynski,Todd Z. DeSantis,Janet Warrington,Embriette R. Hyde,Joseph F. Petrosino,Georg K. Gerber,Lynn Bry,Hans C. Oettgen,Sarkis K. Mazmanian,Talal A. Chatila +16 more
TL;DR: Mice with food allergy exhibit a specific gut microbiota signature capable of transmitting disease susceptibility and subject to reprogramming by enforced tolerance, and disease-associated microbiota may play a pathogenic role in food allergy.