George C. Wang

TL;DR: Analytical tools developed develop a distance measure on the space of TCRs that permits clustering and visualization, a robust repertoire diversity metric that accommodates the low number of paired public receptors observed when compared to single-chain analyses, and a distance-based classifier that can assign previously unobserved T CRs to characterized repertoires with robust sensitivity and specificity.

TL;DR: Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection.

TL;DR: The authors used a single-cell strategy for the clonotypic analysis of human CD8+ TCRαβ repertoires and found that the repertoire diversity, but not the magnitude, of the T cell response was inversely related to antibody levels, which suggests that expanding diversity is a critical target for immunotherapy.

TL;DR: Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization ofCMV-specific T cells, impact of CMVs infection and ageing on innate immunity, and finally, most important, the clinical implications of immun Rosenescence and CMV infection.

TL;DR: It is suggested that vaccination strategies aimed at generating broad protection should incorporate variant peptides to elicit cross-reactive responses against other specificities, especially those that may be relatively infrequent among IAV-primed memory CTLs.