G
George W. Nelson
Researcher at Leidos
Publications - 84
Citations - 14306
George W. Nelson is an academic researcher from Leidos. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 44, co-authored 82 publications receiving 13204 citations. Previous affiliations of George W. Nelson include Science Applications International Corporation & National Institutes of Health.
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Journal ArticleDOI
Association of trypanolytic ApoL1 variants with kidney disease in African Americans.
Giulio Genovese,Giulio Genovese,David J. Friedman,Michael D. Ross,Laurence Lecordier,Pierrick Uzureau,Barry I. Freedman,Donald W. Bowden,Carl D. Langefeld,Taras K. Oleksyk,Andrea L. Uscinski Knob,Andrea J. Bernhardy,Pamela J. Hicks,George W. Nelson,Benoit Vanhollebeke,Cheryl A. Winkler,Jeffrey B. Kopp,Etienne Pays,Martin R. Pollak,Martin R. Pollak +19 more
TL;DR: This article showed that focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 gene on chromosome 22.
Association of Trypanolytic ApoL1 Variants with Kidney Disease in
Giulio Genovese,David J. Friedman,Michael W. Ross,Laurence Lecordier,Pierrick Uzureau,Barry I. Freedman,Donald W. Bowden,Carl D. Langefeld,Taras K. Oleksyk,Andrea L. Uscinski Knob,Andrea J. Bernhardy,Pamela J. Hicks,George W. Nelson,Benoit Vanhollebeke,Cheryl A. Winkler,Jeffrey B. Kopp,Etienne Pays,Martin R. Pollak +17 more
TL;DR: In African Americans, focal segmental glomerulosclerosis and hypertension-attributed end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 gene on chromosome 22, which speculate that evolution of a critical survival factor in Africa may have contributed to the high rates of renal disease in African Americans.
Journal ArticleDOI
HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
Mary Carrington,George W. Nelson,Maureen P. Martin,Teri Kissner,David Vlahov,James J. Goedert,Richard A. Kaslow,Susan Buchbinder,Keith Hoots,Stephen J. O'Brien +9 more
TL;DR: The extended survival of 28 to 40 percent of HIV-1-infected Caucasian patients who avoided AIDS for ten or more years can be attributed to their being fully heterozygous at HLA class I loci, to their lacking the AIDS-associated alleles B*35 and Cw*04, or to both.
Journal ArticleDOI
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
Maureen P. Martin,Xiaojiang Gao,Jeong Hee Lee,George W. Nelson,Roger Detels,James J. Goedert,Susan Buchbinder,Keith Hoots,David Vlahov,John Trowsdale,Michael A Wilson,Michael A Wilson,Stephen J. O'Brien,Mary Carrington +13 more
TL;DR: The strongest synergistic effect of these loci was on progression to depletion of CD4+ T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection.
Journal ArticleDOI
Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Cheryl A. Winkler,William S. Modi,Michael W. Smith,George W. Nelson,Xueyun Wu,Mary Carrington,Michael Dean,Tasaku Honjo,Kai Tashiro,Daisuke Yabe,Susan Buchbinder,Eric Vittinghoff,James J. Goedert,Thomas R. O'Brien,Lisa P. Jacobson,Roger Detels,Sharyne Donfield,Anne Willoughby,Edward D. Gomperts,David Vlahov,John P. Phair,Stephen J. O'Brien +21 more
TL;DR: The recessive protective effect of SDF1-3'A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.