G
Georgios I. Karras
Researcher at Massachusetts Institute of Technology
Publications - 12
Citations - 2289
Georgios I. Karras is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: DNA repair & Eukaryotic DNA replication. The author has an hindex of 10, co-authored 10 publications receiving 2018 citations. Previous affiliations of Georgios I. Karras include Max Planck Society.
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Journal ArticleDOI
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Mikko Taipale,Irina Krykbaeva,Martina Koeva,Can Kayatekin,Kenneth D. Westover,Georgios I. Karras,Susan Lindquist,Susan Lindquist +7 more
TL;DR: In this paper, the authors systematically and quantitatively surveyed most human kinases, transcription factors, and E3 ligases for interaction with HSP90 and its cochaperone CDC37.
Journal ArticleDOI
The macro domain is an ADP-ribose binding module
Georgios I. Karras,Georg Kustatscher,Heeran R Buhecha,Mark D. Allen,Céline Pugieux,Fiona Sait,Mark Bycroft,Andreas G. Ladurner +7 more
TL;DR: In this article, the authors provide biochemical and structural evidence that macro domains are high affinity binding modules for ADP-ribose nucleotide nucleotides and reveal a conserved ligand binding pocket among the macro domain fold.
Journal ArticleDOI
Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders
Nidhi Sahni,Song Yi,Mikko Taipale,Juan I. Fuxman Bass,Jasmin Coulombe-Huntington,Fan Yang,Fan Yang,Jian Peng,Jochen Weile,Jochen Weile,Georgios I. Karras,Yang Wang,István Kovács,István Kovács,Atanas Kamburov,Irina Krykbaeva,Mandy H. Y. Lam,George Tucker,Vikram Khurana,Amitabh Sharma,Amitabh Sharma,Yang-Yu Liu,Yang-Yu Liu,Nozomu Yachie,Nozomu Yachie,Quan Zhong,Yun Shen,Alexandre Palagi,Adriana San-Miguel,Changyu Fan,Dawit Balcha,Amélie Dricot,Daniel M. Jordan,Jennifer M. Walsh,Akash A. Shah,Xinping Yang,Ani K. Stoyanova,Alex Leighton,Michael A. Calderwood,Yves Jacob,Yves Jacob,Michael E. Cusick,Kourosh Salehi-Ashtiani,Luke Whitesell,Shamil R. Sunyaev,Shamil R. Sunyaev,Bonnie Berger,Albert-László Barabási,Albert-László Barabási,Benoit Charloteaux,David E. Hill,Tong Hao,Frederick P. Roth,Frederick P. Roth,Frederick P. Roth,Yu Xia,Yu Xia,Albertha J.M. Walhout,Albertha J.M. Walhout,Susan Lindquist,Susan Lindquist,Marc Vidal +61 more
TL;DR: This work functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays, suggesting that disease-associated alleles that perturb distinct protein activities rather than grossly affecting folding and stability are relatively widespread.
Journal ArticleDOI
The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase
TL;DR: These findings indicate that both branches of the DNA damage tolerance pathway operate effectively after chromosomal replication, outside S phase, and propose that the RAD6 pathway acts on single-stranded gaps left behind newly restarted replication forks.
Journal ArticleDOI
HSP90 Shapes the Consequences of Human Genetic Variation
Georgios I. Karras,Song Yi,Nidhi Sahni,Máté Fischer,Jenny Xie,Marc Vidal,Alan D. D'Andrea,Luke Whitesell,Susan Lindquist +8 more
TL;DR: A compensatory FANCA somatic mutation from an "experiment of nature" in monozygotic twins both prevented anemia and reduced HSP90 binding and provides one plausible mechanism for the variable expressivity and environmental sensitivity of genetic diseases.