J
Jasmin Coulombe-Huntington
Researcher at Université de Montréal
Publications - 40
Citations - 4819
Jasmin Coulombe-Huntington is an academic researcher from Université de Montréal. The author has contributed to research in topics: Gene & Alternative splicing. The author has an hindex of 17, co-authored 35 publications receiving 3398 citations. Previous affiliations of Jasmin Coulombe-Huntington include McGill University & Boston University.
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Journal ArticleDOI
A proteome-scale map of the human interactome network
Thomas Rolland,Murat Tasan,Benoit Charloteaux,Samuel J. Pevzner,Quan Zhong,Quan Zhong,Nidhi Sahni,Song Yi,Irma Lemmens,Celia Fontanillo,Roberto Mosca,Atanas Kamburov,Susan Dina Ghiassian,Susan Dina Ghiassian,Xinping Yang,Lila Ghamsari,Dawit Balcha,Bridget E. Begg,Pascal Braun,Marc Brehme,Martin P. Broly,Anne-Ruxandra Carvunis,Dan Convery-Zupan,Roser Corominas,Jasmin Coulombe-Huntington,Jasmin Coulombe-Huntington,Elizabeth Dann,Matija Dreze,Amélie Dricot,Changyu Fan,Eric A. Franzosa,Eric A. Franzosa,Fana Gebreab,Bryan J. Gutierrez,Madeleine F. Hardy,Mike Jin,Shuli Kang,Ruth Kiros,Guan Ning Lin,Katja Luck,Andrew MacWilliams,Jörg Menche,Jörg Menche,Ryan R. Murray,Alexandre Palagi,Matthew M. Poulin,Xavier Rambout,Xavier Rambout,John Rasla,Patrick Reichert,Viviana Romero,Elien Ruyssinck,Julie M. Sahalie,Annemarie Scholz,Akash A. Shah,Amitabh Sharma,Amitabh Sharma,Yun Shen,Kerstin Spirohn,Stanley Tam,Alexander O. Tejeda,Shelly A. Trigg,Jean-Claude Twizere,Jean-Claude Twizere,Kerwin Vega,Jennifer M. Walsh,Michael E. Cusick,Yu Xia,Yu Xia,Albert-László Barabási,Albert-László Barabási,Albert-László Barabási,Lilia M. Iakoucheva,Patrick Aloy,Javier De Las Rivas,Jan Tavernier,Michael A. Calderwood,David E. Hill,Tong Hao,Frederick P. Roth,Marc Vidal +80 more
TL;DR: The map uncovers significant interconnectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help "connect the dots" of the genomic revolution.
Journal ArticleDOI
The BioGRID interaction database: 2019 update
Rose Oughtred,Chris Stark,Bobby-Joe Breitkreutz,Jennifer M. Rust,Lorrie Boucher,Christie S. Chang,Nadine Kolas,Lara O'Donnell,Genie Leung,Rochelle McAdam,Frederick Zhang,Sonam Dolma,Andrew Willems,Jasmin Coulombe-Huntington,Andrew Chatr-aryamontri,Kara Dolinski,Mike Tyers,Mike Tyers +17 more
TL;DR: A new dedicated aspect of BioGRID annotates genome-wide CRISPR/Cas9-based screens that report gene–phenotype and gene–gene relationships, and captures chemical interaction data, including chemical–protein interactions for human drug targets drawn from the DrugBank database and manually curated bioactive compounds reported in the literature.
Journal ArticleDOI
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.
Rose Oughtred,Jennifer M. Rust,Christie S. Chang,Bobby-Joe Breitkreutz,Chris Stark,Andrew Willems,Lorrie Boucher,Genie Leung,Nadine Kolas,Frederick Zhang,Sonam Dolma,Jasmin Coulombe-Huntington,Andrew Chatr-aryamontri,Kara Dolinski,Mike Tyers,Mike Tyers +15 more
TL;DR: The BioGRID (Biological General Repository for Interaction Datasets, thebiogrid.org) is an open‐access database resource that houses manually curated protein and genetic interactions from multiple species including yeast, worm, fly, mouse, and human.
Journal ArticleDOI
Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders
Nidhi Sahni,Song Yi,Mikko Taipale,Juan I. Fuxman Bass,Jasmin Coulombe-Huntington,Fan Yang,Fan Yang,Jian Peng,Jochen Weile,Jochen Weile,Georgios I. Karras,Yang Wang,István Kovács,István Kovács,Atanas Kamburov,Irina Krykbaeva,Mandy H. Y. Lam,George Tucker,Vikram Khurana,Amitabh Sharma,Amitabh Sharma,Yang-Yu Liu,Yang-Yu Liu,Nozomu Yachie,Nozomu Yachie,Quan Zhong,Yun Shen,Alexandre Palagi,Adriana San-Miguel,Changyu Fan,Dawit Balcha,Amélie Dricot,Daniel M. Jordan,Jennifer M. Walsh,Akash A. Shah,Xinping Yang,Ani K. Stoyanova,Alex Leighton,Michael A. Calderwood,Yves Jacob,Yves Jacob,Michael E. Cusick,Kourosh Salehi-Ashtiani,Luke Whitesell,Shamil R. Sunyaev,Shamil R. Sunyaev,Bonnie Berger,Albert-László Barabási,Albert-László Barabási,Benoit Charloteaux,David E. Hill,Tong Hao,Frederick P. Roth,Frederick P. Roth,Frederick P. Roth,Yu Xia,Yu Xia,Albertha J.M. Walhout,Albertha J.M. Walhout,Susan Lindquist,Susan Lindquist,Marc Vidal +61 more
TL;DR: This work functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays, suggesting that disease-associated alleles that perturb distinct protein activities rather than grossly affecting folding and stability are relatively widespread.
Journal ArticleDOI
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
Xinping Yang,Xinping Yang,Jasmin Coulombe-Huntington,Shuli Kang,Gloria M. Sheynkman,Tong Hao,Aaron Richardson,Song Sun,Song Sun,Fan Yang,Yun A. Shen,Ryan R. Murray,Ryan R. Murray,Kerstin Spirohn,Bridget E. Begg,Bridget E. Begg,Miquel Duran-Frigola,Andrew MacWilliams,Samuel J. Pevzner,Samuel J. Pevzner,Quan Zhong,Quan Zhong,Shelly A. Trigg,Stanley Tam,Lila Ghamsari,Nidhi Sahni,Song Yi,Maria D. Rodriguez,Maria D. Rodriguez,Dawit Balcha,Guihong Tan,Michael Costanzo,Brenda J. Andrews,Charles Boone,Xianghong Jasmine Zhou,Kourosh Salehi-Ashtiani,Kourosh Salehi-Ashtiani,Benoit Charloteaux,Benoit Charloteaux,Alyce A. Chen,Michael A. Calderwood,Patrick Aloy,Frederick P. Roth,Frederick P. Roth,Frederick P. Roth,David E. Hill,Lilia M. Iakoucheva,Yu Xia,Yu Xia,Marc Vidal +49 more
TL;DR: This work cloned full-length open reading frames of alternatively spliced transcripts for a large number of human genes and used protein-protein interaction profiling to functionally compare hundreds of protein isoform pairs, revealing a widespread expansion of protein interaction capabilities through alternative splicing and suggesting that many alternative "isoforms" are functionally divergent (i.e., "functional alloforms").