G
Geraldine S. Pinkus
Researcher at Brigham and Women's Hospital
Publications - 286
Citations - 29136
Geraldine S. Pinkus is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Lymphoma & Immunoperoxidase. The author has an hindex of 84, co-authored 278 publications receiving 27112 citations. Previous affiliations of Geraldine S. Pinkus include University of Texas MD Anderson Cancer Center & Montreal General Hospital.
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Journal ArticleDOI
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
Margaret A. Shipp,Kenneth N. Ross,Pablo Tamayo,Andrew P. Weng,Jeffery L. Kutok,Ricardo C.T. Aguiar,Michelle Gaasenbeek,Michael Angelo,Michael R. Reich,Geraldine S. Pinkus,Tane S. Ray,Margaret A. Koval,Andrew Norton,T. Andrew Lister,Jill P. Mesirov,Donna Neuberg,Eric S. Lander,Jon C. Aster,Todd R. Golub +18 more
TL;DR: Genes implicated in DLBCL outcome included some that regulate responses to B-cell–receptor signaling, critical serine/threonine phosphorylation pathways and apoptosis, and identify rational targets for intervention.
Journal ArticleDOI
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Adriana Donovan,Alison Brownlie,Alison Brownlie,Yi Zhou,Jennifer L. Shepard,Stephen J. Pratt,John Moynihan,Barry H. Paw,Anna Drejer,Bruce A. Barut,Bruce A. Barut,Agustín G. Zapata,Terence C. Law,Carlo Brugnara,Samuel E. Lux,Geraldine S. Pinkus,Jack L. Pinkus,Paul D. Kingsley,James Palis,Mark D. Fleming,Mark D. Fleming,Nancy C. Andrews,Nancy C. Andrews,Leonard I. Zon,Leonard I. Zon +24 more
TL;DR: The gene responsible for the hypochromic anaemia of the zebrafish mutant weissherbst is identified and Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload.
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MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
Journal ArticleDOI
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Adriana Donovan,Adriana Donovan,Christine A. Lima,Christine A. Lima,Jack L. Pinkus,Geraldine S. Pinkus,Leonard I. Zon,Leonard I. Zon,Leonard I. Zon,Sylvie Robine,Nancy C. Andrews,Nancy C. Andrews,Nancy C. Andrews +12 more
TL;DR: Intestine-specific inactivation of ferroportin confirmed that it is critical for intestinal iron absorption and gave insight into hemochromatosis.
Journal ArticleDOI
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
Stefano Monti,Kerry J. Savage,Jeffery L. Kutok,Friedrich Feuerhake,Paul J. Kurtin,Martin C. Mihm,Bingyan Wu,Laura Pasqualucci,Donna Neuberg,Ricardo C.T. Aguiar,Paola Dal Cin,Christine Ladd,Geraldine S. Pinkus,Gilles Salles,Nancy L. Harris,Riccardo Dalla-Favera,Thomas M. Habermann,Jon C. Aster,Todd R. Golub,Todd R. Golub,Margaret A. Shipp +20 more
TL;DR: Tumor microenvironment and host inflammatory response as defining features in DLBCL are identified and rational treatment targets in specificDLBCL subsets are suggested.