G
Gordon Ruthel
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 24
Citations - 2869
Gordon Ruthel is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Ebola virus & Dendritic cell. The author has an hindex of 19, co-authored 24 publications receiving 2636 citations.
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Journal ArticleDOI
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
Jan E. Carette,Jan E. Carette,Matthijs Raaben,Anthony C. Wong,Andrew S. Herbert,Gregor Obernosterer,Gregor Obernosterer,Nirupama Mulherkar,Ana I. Kuehne,Philip J. Kranzusch,April M. Griffin,Gordon Ruthel,Paola Dal Cin,John M. Dye,Sean P. J. Whelan,Kartik Chandran,Thijn R. Brummelkamp,Thijn R. Brummelkamp +17 more
TL;DR: It is shown that membrane fusion mediated by filovirus glycoproteins and viral escape from the vesicular compartment require the NPC1 protein, independent of its known function in cholesterol transport, which indicates potential antiviral strategies to combat these deadly agents.
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Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization
Mansour Mohamadzadeh,Scott D. Olson,Warren V. Kalina,Gordon Ruthel,Gretchen L. Demmin,Kelly L. Warfield,Sina Bavari,Todd R. Klaenhammer +7 more
TL;DR: The results emphasize a potentially important role for lactobacilli in modulating immunological functions of DCs and suggest that certain strains could be particularly advantageous as vaccine adjuvants, by promoting DCs to regulate T cell responses toward T helper 1 and Tc1 pathways.
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Ebola and Marburg Viruses Replicate in Monocyte-Derived Dendritic Cells without Inducing the Production of Cytokines and Full Maturation
Catharine M. Bosio,M. Javad Aman,Case C. Grogan,Robert J. Hogan,Gordon Ruthel,Diane L. Negley,Mansour Mohamadzadeh,Sina Bavari,Alan L. Schmaljohn +8 more
TL;DR: It is demonstrated that EBOV and MARV infected and replicated in primary human DCs without inducing cytokine secretion, and DCs are disabled, and an effective early host response is delayed by the necessary reliance on less-efficient secondary mechanisms.
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3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells
Richard L. Felts,Kedar Narayan,Jacob D. Estes,Dan Shi,Charles M. Trubey,Jing Fu,Lisa M. Hartnell,Gordon Ruthel,Douglas K. Schneider,Kunio Nagashima,Julian W. Bess,Sina Bavari,Bradley C. Lowekamp,Donald Bliss,Jeffrey D. Lifson,Sriram Subramaniam +15 more
TL;DR: The relative seclusion of T cells from the extracellular milieu, the burial of the site of HIV transfer, and the receptor-dependent initiation of virion transfer by T cells highlight unique aspects of cell-cell HIV transmission.
Journal ArticleDOI
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
James C. Burnett,Gordon Ruthel,Christian Stegmann,Rekha G. Panchal,Tam Luong Nguyen,Ann R. Hermone,Robert G. Stafford,Douglas Lane,Tara Kenny,Connor F. McGrath,Peter Wipf,Andrea M. Stahl,James J. Schmidt,Rick Gussio,Axel T. Brunger,Sina Bavari +15 more
TL;DR: Of these, NSC 240898 is a promising lead for therapeutic development, as it readily enters neurons, exhibits no neuronal toxicity, and elicits dose-dependent protection of synaptosomal-associated protein in a primary culture of embryonic chicken neurons.