H
Helen Ray-Jones
Researcher at University of Manchester
Publications - 14
Citations - 219
Helen Ray-Jones is an academic researcher from University of Manchester. The author has contributed to research in topics: Genome-wide association study & Enhancer. The author has an hindex of 6, co-authored 12 publications receiving 110 citations. Previous affiliations of Helen Ray-Jones include Manchester Academic Health Science Centre & Imperial College London.
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Journal ArticleDOI
TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.
Jessica Sook Yuin Ho,Bobo Wing-Yee Mok,Laura Campisi,Tristan X. Jordan,Soner Yildiz,Sreeja Parameswaran,Joseph A. Wayman,Joseph A. Wayman,Natasha N. Gaudreault,David A. Meekins,Sabarish V. Indran,Igor Morozov,Jessie D. Trujillo,Yesai Fstkchyan,Raveen Rathnasinghe,Zeyu Zhu,Simin Zheng,Nan Zhao,Kris M. White,Helen Ray-Jones,Valeriya Malysheva,Michiel J. Thiecke,Siu Ying Lau,Honglian Liu,Anna Junxia Zhang,Andrew Chak-Yiu Lee,Wen-Chun Liu,Sonia Jangra,Alba Escalera,Teresa Aydillo,Betsaida Salom Melo,Ernesto Guccione,Robert Sebra,Elaine Shum,Jan Bakker,Jan Bakker,Jan Bakker,David A. Kaufman,Andre L. Moreira,Mariano Carossino,Udeni B. R. Balasuriya,Minji Byun,Randy A. Albrecht,Michael Schotsaert,Adolfo García-Sastre,Sumit K. Chanda,Emily R. Miraldi,Emily R. Miraldi,Anand D. Jeyasekharan,Benjamin R. tenOever,Mikhail Spivakov,Matthew T. Weirauch,Matthew T. Weirauch,Sven Heinz,Honglin Chen,Christopher Benner,Juergen A. Richt,Ivan Marazzi +57 more
TL;DR: In this paper, using multidimensional epigenetic, transcriptional, in-vitro, and invivo analyses, the authors reported that topoisomerase 1 (TOP1) inhibition suppresses lethal inflammation induced by SARS-CoV-2.
Journal ArticleDOI
One SNP at a Time: Moving beyond GWAS in Psoriasis
TL;DR: Current approaches toward gaining a complete understanding of how these known genetic loci contribute to an increased disease risk in psoriasis are focused on.
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Chromatin interactions reveal novel gene targets for drug repositioning in rheumatic diseases.
Paul Martin,James Ding,Kate Duffus,Vasanthi Priyadarshini Gaddi,Amanda McGovern,Helen Ray-Jones,Annie Yarwood,Jane Worthington,Anne Barton,Gisela Orozco +9 more
TL;DR: Capture Hi-C has the potential to identify therapies which could be repositioned to treat rheumatic diseases, and was particularly successful for rheumatoid arthritis, where six effective, biologic treatments were identified.
Journal ArticleDOI
Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31
Helen Ray-Jones,Helen Ray-Jones,Kate Duffus,Amanda McGovern,Paul Martin,Chenfu Shi,Jenny Hankinson,Oliver Gough,Annie Yarwood,Annie Yarwood,Andrew P. Morris,Antony Adamson,Christopher J. Taylor,James Ding,Vasanthi Priyadarshini Gaddi,Yao Fu,Patrick M. Gaffney,Gisela Orozco,Richard B. Warren,Steve Eyre +19 more
TL;DR: This approach utilises multiple functional genomic techniques to follow up GWAS-associated variants implicating relevant cell types and causal genes in each locus; these are vital next steps for the translation of genetic findings into clinical benefit.
Journal ArticleDOI
Detecting chromosomal interactions in Capture Hi-C data with CHiCAGO and companion tools.
Paula Freire-Pritchett,Helen Ray-Jones,Helen Ray-Jones,Monica Della Rosa,Monica Della Rosa,Chris Eijsbouts,William R. Orchard,Steven Wingett,Steven Wingett,Chris Wallace,Jonathan Cairns,Mikhail Spivakov,Mikhail Spivakov,Valeriya Malysheva,Valeriya Malysheva +14 more
TL;DR: The Capture Hi-C Analysis of Genomic Organization (CHiCAGO) as mentioned in this paper is a computational pipeline developed specifically for Capture HiC analysis, which implements a statistical model accounting for biological and technical background components, as well as bespoke normalization and multiple testing procedures.