H
Hildur Knutsdottir
Researcher at Johns Hopkins University
Publications - 19
Citations - 565
Hildur Knutsdottir is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 8, co-authored 15 publications receiving 252 citations. Previous affiliations of Hildur Knutsdottir include University of British Columbia.
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Journal ArticleDOI
Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity.
Ling Li,Hildur Knutsdottir,Ken Hui,Matthew J. Weiss,Jin He,Benjamin Philosophe,Andrew M. Cameron,Christopher L. Wolfgang,Timothy M. Pawlik,Gabriel Ghiaur,Andrew J. Ewald,Esteban Mezey,Joel S. Bader,Florin M. Selaru +13 more
TL;DR: It is found that a subset of drugs appeared pan-effective, displaying at least moderate activity in the majority of these cancer organoid lines, and these drugs, which are FDA approved for indications other than liver cancers, deserve further consideration as either systemic or local therapeutics.
Journal ArticleDOI
An expanded universe of cancer targets.
William C. Hahn,Joel S. Bader,Theodore P. Braun,Andrea Califano,Paul A. Clemons,Brian J. Druker,Andrew J. Ewald,Haian Fu,Subhashini Jagu,Christopher J. Kemp,William Kim,Calvin J. Kuo,Michael T. McManus,Gordon B. Mills,Xiulei Mo,Nidhi Sahni,Stuart L. Schreiber,Jessica A. Talamas,Pablo Tamayo,Jeffrey W. Tyner,Bridget K. Wagner,William A. Weiss,Daniela S. Gerhard,Vlado Dančík,Shubhroz Gill,Bruce K. Hua,Tanaz Sharifnia,Vasanthi S. Viswanathan,Yilong Zou,Filemon S. Dela Cruz,Andrew L. Kung,Brent R. Stockwell,Jesse S. Boehm,Josh Dempster,Robert T. Manguso,Francisca Vazquez,Lee Cooper,Yuhong Du,Andrey A. Ivanov,Sagar Lonial,Carlos S. Moreno,Qiankun Niu,Taofeek K. Owonikoko,Suresh S. Ramalingam,Matthew A. Reyna,Wei Zhou,Carla Grandori,Ilya Shmulevich,Elizabeth M. Swisher,Jitong Cai,Issac S. Chan,Matthew Dunworth,Yuchen Ge,Dan Georgess,Eloise M. Grasset,Elodie Henriet,Hildur Knutsdottir,Michael G. Lerner,Veena Padmanaban,Matthew C. Perrone,Yasir Suhail,Yohannes Tsehay,Manisha Warrier,Quin Morrow,Tamilla Nechiporuk,Nicola Long,Jennifer Saultz,Andy Kaempf,Jessica Minnier,Cristina E. Tognon,Stephen E. Kurtz,Anupriya Agarwal,Jordana Brown,Kevin Watanabe-Smith,Tania Q. Vu,Thomas Jacob,Yunqi Yan,Bridget Robinson,Evan F. Lind,Yoko Kosaka,Emek Demir,Joseph Estabrook,Michael Grzadkowski,Olga Nikolova,Ken Chen,Ben Deneen,Han Liang,Michael C. Bassik,Asmita Bhattacharya,Kevin C. Brennan,Christina Curtis,Olivier Gevaert,Hanlee P. Ji,Kasper Karlsson,Kremena Karagyozova,Yuan-Hung Lo,Katherine N. Liu,Michitaka Nakano,Anuja Sathe,Amber R. Smith,Kaitlyn Spees,Wing Hing Wong,Kanako Yuki,Matt Hangauer,Dan S. Kaufman,Allan Balmain,Saumya R. Bollam,Wei-Ching Chen,Qi-Wen Fan,Kelly Kersten,Matthew F. Krummel,Yun Rose Li,Marie Menard,Nicole Nasholm,Christin Schmidt,Nina K. Serwas,Hiroyuki Yoda,Alan Ashworth,Sourav Bandyopadhyay,Trevor Bivona,Gabriel Eades,Stefan Oberlin,Neil Tay,Yuhao Wang,Jonathan S. Weissman +124 more
TL;DR: A framework is described for this expanded list of cancer targets, providing novel opportunities for clinical translation and indicating that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes.
Journal ArticleDOI
Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction.
Virginia S. Hahn,Hildur Knutsdottir,Xin Luo,Kenneth Bedi,Kenneth B. Margulies,Saptarsi M. Haldar,Marina Stolina,Jun Yin,Aarif Y. Khakoo,Joban Vaishnav,Joel S. Bader,David A. Kass,David A. Kass,Kavita Sharma +13 more
TL;DR: RNA sequencing on right ventricular septal endomyocardial biopsies prospectively obtained from patients with consensus criteria for HFpEF revealed new signaling targets to consider for precision therapeutics and confirmed group separation.
Journal ArticleDOI
Mathematical model of macrophage-facilitated breast cancer cells invasion
TL;DR: Simulations with the discrete model show that the ratio between tumor cells and macrophages in aggregates increases when the EGF secretion parameter is increased, and results show how CSF-1/CSf-1R autocrine signalling in tumor cells affects the ratios between the two cell types.
Journal ArticleDOI
Cancer cells educate natural killer cells to a metastasis-promoting cell state
Isaac S. Chan,Hildur Knutsdottir,Gayathri Ramakrishnan,Veena Padmanaban,Manisha Warrier,Juan Carlos Ramirez,Matthew Dunworth,Hao Zhang,Elizabeth M. Jaffee,Joel S. Bader,Andrew J. Ewald,Andrew J. Ewald +11 more
TL;DR: Reprogramming can be blocked by targeting NK cell inhibitory receptors TIGIT or KLRG1 or inhibiting DNA methyltransferases, which suggests new approaches to prevent or treat metastasis.