Bruce K. Hua

TL;DR: A framework is described for this expanded list of cancer targets, providing novel opportunities for clinical translation and indicating that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes.

TL;DR: The synthesis features a novel cascade of reactions of N-stabilized carbocations with π-nucleophiles to create the tetracyclic core of actinophyllic acid in a single chemical operation, and one key intermediate was modified to furnish several novel compounds having potentially promising anticancer activity.

TL;DR: It is shown that stereoisomerism and appendage diversification can produce effects of similar magnitude, and that the concurrent use of these strategies results in a broader sampling of biological activity.

TL;DR: The use of high-dimensional “multiplex” assays, which are capable of measuring thousands of cellular features in one experiment, are proposed to annotate rapidly and inexpensively the biological activities of newly synthesized compounds, indicating that real-time biological annotation can inform optimization efforts and library syntheses by illuminating trends relating to biological activity that would be difficult to predict if only chemical structure were considered.

TL;DR: In this paper, the authors summarize the collective academic, government, and industry experiences regarding cellular nuisance compounds in more complex cell-based assays and suggest best practices to efficiently address these compounds in complex biological settings.