Hiroshi Maeda

TL;DR: Corneal destruction seen with P. aeruginosa infections may result from enhanced expression of MMPs by corneal stromal cells stimulated with pseudomonal exoproteases and proinflammatory cytokines and the proteolytic activation of M MPs by Pseudomonal elastase.

TL;DR: In vivo analysis revealed that intravenously administered SMA-SOD circulated bound to albumin with an extremely long half-life (6 h), while unmodified SOD rapidly underwent renal glomerular filtration with a plasma half- life of 4 min, suggesting that SMA -SOD may effectively dismutase superoxide radicals in the circulation.

TL;DR: The results indicate unambiguously that NO has mutagenic potential for RNA viruses such as Sendai virus without affecting viral replication, possibly via 8-nitroguanosine formation and cellular oxidative stress.

TL;DR: The results suggest that excessive production of O(2)(-) and NO occurs in the late allergic response (LAR) in sensitized guinea pigs in vivo, and these two molecules appear to cause airway microvascular hyperpermeability via peroxynitrite formation.

TL;DR: In this article, two strains of Serratia marcescens were isolated: one from a patient with severe liquefactive keratitis, who had diabetes mellitus, and one from an individual with mild superficial keratitis but who had no underlying disease.