H
Hiroshi Maeda
Researcher at Kumamoto University
Publications - 915
Citations - 67944
Hiroshi Maeda is an academic researcher from Kumamoto University. The author has contributed to research in topics: Neocarzinostatin & Nitric oxide. The author has an hindex of 103, co-authored 893 publications receiving 63370 citations. Previous affiliations of Hiroshi Maeda include Osaka University & Okayama University.
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Generation of free radicals from neocarzinostatin mediated by NADPH/cytochrome P-450 reductase via activation of enediyne chromophore.
TL;DR: The results indicate that NCS is a potent generator of free radicals in cells where cyt P-450 reductase is available, and it seems that free radicals, generated by enzymatic activation of NCS, are involved in cytotoxicity of N CS as well as in DNA damage.
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Generation of magnetic fields over 21 T in a 61 mm clear bore using low copper ratio (Nb,Ti)/sub 3/Sn conductors
TL;DR: A 21 T superconducting magnet system has been developed and improved at the National Research Institute for Metals in Japan as discussed by the authors, which employs three kinds of rectangular (Nb,Ti)/sub 3/sn conductors, with a Cu:SC ratio of only 0.25.
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Interaction of chymotrypsinogens with alpha 1-protease inhibitor.
J W Brodrick,Charles B. Glaser,Corey Largman,Michael C. Geokas,Michael Graceffo,Maria Fassett,Hiroshi Maeda +6 more
TL;DR: The results suggest that zymogens react with alpha 1-protease inhibitor by virtue of partially formed active sites and that the potential active-site specificity of the zymogen in part determines the rate of complex formation.
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Mechanism of Accumulation of the Antitumor Protein Antibiotic Neocarzinostatin in Bladder Tissue: Intravenous Administration, Urinary Excretion, and Absorption into Bladder Tissue
TL;DR: Evidence is presented for the absorption of NCS into bladder tissue from the lumen of the bladder, as shown by the appearance of a low-molecular-weight fragment and by the absence of such an increase in the presence of inhibitors of proteolysis.
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Generation of Metastatic Variants of Eker Renal Carcinoma Cell Lines for Experimental Investigation of Renal Cancer Metastasis
Tomokazu Fukuda,Youko Hirayama,Hiroaki Mitani,Hiroshi Maeda,Masahiro Tsutsumi,Yoichi Konishi,Okio Hino +6 more
TL;DR: To investigate the additional genetic event(s) necessary for cancer metastasis, highly metastatic S‐Lk9d‐SLM cell lines are established from a non‐metastatic RC cell line by co‐implantation with a foreign body (gelatin sponge).