H
Hiroshi Maeda
Researcher at Kumamoto University
Publications - 915
Citations - 67944
Hiroshi Maeda is an academic researcher from Kumamoto University. The author has contributed to research in topics: Neocarzinostatin & Nitric oxide. The author has an hindex of 103, co-authored 893 publications receiving 63370 citations. Previous affiliations of Hiroshi Maeda include Osaka University & Okayama University.
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Book ChapterDOI
Toxicity of Bilirubin and Detoxification by PEG-Bilirubin Oxidase Conjugate
TL;DR: The tactic for the treatment of jaundice is to decompose toxic bilirubin by the enzyme bilirUBin oxidase, and for that purpose the enzyme is made into a polymer conjugate to improve its pharmacological properties.
Journal ArticleDOI
The S-layer protein from Campylobacter rectus: sequence determination and function of the recombinant protein
Manabu Miyamoto,Hiroshi Maeda,Michitaka Kitanaka,Susumu Kokeguchi,Shogo Takashiba,Yoji Murayama +5 more
TL;DR: The gene encoding the crystalline surface layer (S-layer) protein from Campylobacter rectus, designated slp, was sequenced and the recombinant gene product was expressed in Escherichia coli and data support the idea that the N-terminus acts as an anchor to the cell surface components and that the C-terminu is involved in the assembly and/or transport of the protein.
Journal ArticleDOI
Stimulation of non-specific resistance to tumors in the mouse using a poly(maleic-acid-styrene)-conjugated neocarzinostatin.
TL;DR: While the administration of SMANCS induces both IFN-γ andIFN-α/β production, in this case, it is only the former which mediates the non-specific resistance to tumors.
Journal Article
Cytotoxicity of Bacterial Proteases in Various Tumor Cells Mediated through α2-Macroglobulin Receptor
TL;DR: Results suggest a possible mechanism of cytotoxic action of protease: alpha 2M receptor-mediated endocytosis of the complex followed by destruction of cellular integrity after regeneration of proteolytic activity.
Journal ArticleDOI
The growth-stimulating effect of alpha 1-acid glycoprotein in cells in culture.
TL;DR: A highly purified α1-acid glycoprotein (AG) was found to stimulate the growth of cells in culture above 1 μg/ml in a serum-free medium and the presence of other factor(s) besides AG in the heat-denatured supernatant was indicated by YS (Yoshida sarcoma rat) cells which did not respond to AG at all.