H
Hiroshi Maeda
Researcher at Kumamoto University
Publications - 915
Citations - 67944
Hiroshi Maeda is an academic researcher from Kumamoto University. The author has contributed to research in topics: Neocarzinostatin & Nitric oxide. The author has an hindex of 103, co-authored 893 publications receiving 63370 citations. Previous affiliations of Hiroshi Maeda include Osaka University & Okayama University.
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Activation of hageman factor and prekallikrein and generation of kinin by various microbial proteinases.
TL;DR: The enhancement of vascular permeability in guinea pig skin and its sensitivity to inhibitors of activated Hageman factor, plasma kallikrein, or a kininase were examined and the results from the in vivo experiments were consistent with those in vitro.
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Partial Melt Growth Process of Bi2Sr2Ca1Cu2Ox Textured Tapes on Silver
Junichiro Kase,Kazumasa Togano,Hiroaki Kumakura,Daniel R. Dietderich,Naoshi Irisawa,Takeshi Morimoto,Hiroshi Maeda +6 more
TL;DR: Bi2Sr2Ca1Cu2Ox textured tapes with an excellent Jc were synthesized by doctor-blade casting and a melt process as mentioned in this paper, where green tape was laid on a silver foil and oxide/silver composite tape was heat treated.
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SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours
TL;DR: Data indicate that i.v. administration of SMA-Dox micellar formulation can enhance the therapeutic effect of doxorubicin while reducing greatly cardiac and bone marrow toxicity, which should allow safe use of high doses of this agent.
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Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth
Koichi Doi,Takaaki Akaike,Hidechika Horie,Youichiro Noguchi,Shigemoto Fujii,Toru Beppu,Michio Ogawa,Hiroshi Maeda +7 more
TL;DR: The role of NO in solid tumor pathology was further investigated in animal tumor and a possible connection between nitric oxide (NO) and enhanced vascular permeability in solid tumors was reported.
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Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application
TL;DR: The EPR effect was enhanced by applying nitroglycerin (NG) ointment on the skin of tumor‐bearing animals, and thus enhanced the delivery of the drug to tumors, and enhanced therapeutic effects.