Hiroshi Maeda

TL;DR: Using a combination of immunohistochemistry and reverse transcriptase-dependent in situ polymerase chain reaction analysis, monocytes expressing inducible nitric oxide synthase (iNOS) are identified to be prevalent in the plaque areas of post mortem brain tissue from patients with MS.

TL;DR: The molecular weight-dependence of tumour capture of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers was studied in vivo using subcutaneous Sarcoma 180 or B16F10 melanoma models and the ratio (accumulation index, AI) of the AUC in tumour to A UC in skeletal muscle (a typical normal tissue) increasing from six to 12 with increasing copolymer molecular weight.

TL;DR: A clinical evaluation of arterial infusion of high-molecular-weight antitumor agent SMANCS dissolved in lipid lymphographic agent (thiodol) in 44 patients with mostly unresectable hepatoma demonstrated significant merits both therapeutically and diagnostically.

TL;DR: Results indicate that generation of oxygen-free radicals by XO, coupled with catabolic supply of hypoxanthine from adenosine catabolism, is a pathogenic principle in influenza virus infection in mice and that a therapeutic approach by elimination of oxygen radicals thus seems possible.

TL;DR: The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid tumors that is related to their particular anatomical and pathophysiological characteristics, which lead to tumor tissues showing considerable extravasation of plasma components and nanomedicines.