H
Hiroshi Maeda
Researcher at Kumamoto University
Publications - 915
Citations - 67944
Hiroshi Maeda is an academic researcher from Kumamoto University. The author has contributed to research in topics: Neocarzinostatin & Nitric oxide. The author has an hindex of 103, co-authored 893 publications receiving 63370 citations. Previous affiliations of Hiroshi Maeda include Osaka University & Okayama University.
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A new simple fluorometric assay for phagocytosis.
Tatsuya Oda,Hiroshi Maeda +1 more
TL;DR: A highly sensitive, but simple and quantitative, fluorometric assay method for phagocytosis by cells such as macrophages and polymorphonuclear leukocytes was developed by utilizing fluorescent particles by utilizing E. coli, Serratia marcescens, yeast, and latex particles.
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High-loading nanosized micelles of copoly(styrene–maleic acid)–zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor
Arun K. Iyer,Khaled Greish,Khaled Greish,Jun Fang,Ryoichi Murakami,Hiroshi Maeda,Hiroshi Maeda +6 more
TL;DR: The unique features of SMA-ZnPP micelles are that they are nanoparticles in aqueous solution having high water solubility and loading, yet macromolecular in nature, which can be beneficial in targeted release of a potent HO-1 inhibitor.
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Viral mutation accelerated by nitric oxide production during infection in vivo
Takaaki Akaike,Shigemoto Fujii,Atsushi Kato,Jun Yoshitake,Yoichi Miyamoto,Tomohiro Sawa,Shinichiro Okamoto,Moritaka Suga,Makoto Asakawa,Yoshiyuki Nagai,Hiroshi Maeda +10 more
TL;DR: The results indicate that the oxidative stress induced by NO produced during the natural course of viral infection increases mutation, expands the quasispecies spectrum, and facilitates evolution of RNA viruses.
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Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage
Hideaki Nakamura,Tomáš Etrych,Petr Chytil,Manami Ohkubo,Jun Fang,Karel Ulbrich,Hiroshi Maeda +6 more
TL;DR: It is determined in the study here that the acid-cleavable PHPMA-hyd-THP conjugate had an excellent antitumor effect without appreciable adverse effects.
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Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger.
TL;DR: In this article, a wide range of biological functions of nitric oxide (NO) was analyzed using a newly discovered NO scavenger, 2-phenyl-4,4,5,5-tetramethylimidazolineoxyl 1-oxyl-3oxide (PTIO) or its water-soluble derivative carboxy-PTIO.