H
Hiroshi Maeda
Researcher at Kumamoto University
Publications - 915
Citations - 67944
Hiroshi Maeda is an academic researcher from Kumamoto University. The author has contributed to research in topics: Neocarzinostatin & Nitric oxide. The author has an hindex of 103, co-authored 893 publications receiving 63370 citations. Previous affiliations of Hiroshi Maeda include Osaka University & Okayama University.
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Bactericidal activity of alkyl peroxyl radicals generated by heme-iron-catalyzed decomposition of organic peroxides.
Takaaki Akaike,Keizo Sato,Sumiko Ijiri,Yoichi Miyamoto,Masahiro Kohno,Masayuki Ando,Hiroshi Maeda +6 more
TL;DR: It is assumed that alkyl peroxyl radicals are the potent molecular species that are cytotoxic against bacteria, whereas alkoxy radicals generated in this system do not affect bacterial viability.
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KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation
Yukimasa Shiotsu,Hitoshi Kiyoi,Yuichi Ishikawa,Ryohei Tanizaki,Makiko Shimizu,Hiroshi Umehara,Kenichi Ishii,Yumiko Mori,Kazutaka Ozeki,Yosuke Minami,Akihiro Abe,Hiroshi Maeda,Tadakazu Akiyama,Yutaka Kanda,Yuko Sato,Shiro Akinaga,Tomoki Naoe +16 more
TL;DR: Results indicate KW-2449 has potent growth inhibitory activity against various types of leukemia by several mechanisms of action and warrants clinical study in leukemia patients with FLT3 mutations as well as imatinib-resistant mutations.
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Pathogenic mechanisms induced by microbial proteases in microbial infections.
Hiroshi Maeda,T Yamamoto +1 more
TL;DR: Microbial proteases are very critical in enhancing pathogenesis of severe diseases and are capable of degrading immunoglobulins and components of the complement system and facilitate propagation of micro organisms.
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Helicobacter pylori urease suppresses bactericidal activity of peroxynitrite via carbon dioxide production.
Hideo Kuwahara,Yoichi Miyamoto,Takaaki Akaike,Tatsuo Kubota,Tomohiro Sawa,Shinichiro Okamoto,Hiroshi Maeda +6 more
TL;DR: Results suggest that H. pylori-associated urease functions to produce a potent ONOO− scavenger, CO2/HCO3−, that defends the bacteria from OnOO− cytotoxicity, and may facilitate sustained bacterial colonization in the infected gastric mucosa.
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Antioxidative and antimutagenic activities of 4-vinyl-2,6-dimethoxyphenol (canolol) isolated from canola oil
Hideo Kuwahara,Ayako Kanazawa,Daisuke Wakamatu,Shigeru Morimura,Kenji Kida,Takaaki Akaike,Hiroshi Maeda +6 more
TL;DR: Canolol suppressed ONOO--induced bactericidal action and reduced intracellular oxidative stress and apoptosis in human cancer SW480 cells when used at a concentration below 20 μM under H2O2-induced oxidative stress.