Hiroshi Maeda

TL;DR: High level of NO produced by iNOS is a pathogenic factor in HSV-1-induced encephalitis in rats, and treatment of virus-infected animals with the NOS inhibitor Nomega-monomethyl-l-arginine significantly ameliorated not only clinical symptoms such as paralysis and seizures but also mortality.

TL;DR: The results indicate that EM may have substantial therapeutic value for various acute inflammatory disorders such as influenza-virus-induced pneumonia, by inhibiting inflammatory-cell responses and suppressing NO overproduction in the lung.

TL;DR: It is reported that the administration of hydroxyurea, an antitumor drug, to rats at pharmacological doses formed detectable nitrosyl hemoglobin, which increased with dose, which verified that nitric oxide detected as nitro SYL hemoglobin or nitroSyl hemoprotein complexes in rats was the result of the metabolism of hydroXYurea.

TL;DR: S-nitrosated human serum albumin dimer (SNO-HSA Dimer) could enhance the therapeutic effect of nab-PTX even in low vascular permeability or intractable pancreatic cancers.

TL;DR: The synergistic effects of light induced photosensitizing capabilities and HO-1 inhibitory potentials of these unique micelles of ZnPP when tested in vitro and in vivo on tumor models under localized, mild illumination conditions using a tungsten–xenon light source indicate that they portend to be promising candidates for targeted chemotherapy as well as photodynamic therapy against superficial tumors aswell as solid tumors located at light penetrable depths.