H
Hiroshi Maeda
Researcher at Kumamoto University
Publications - 915
Citations - 67944
Hiroshi Maeda is an academic researcher from Kumamoto University. The author has contributed to research in topics: Neocarzinostatin & Nitric oxide. The author has an hindex of 103, co-authored 893 publications receiving 63370 citations. Previous affiliations of Hiroshi Maeda include Osaka University & Okayama University.
Papers
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Journal ArticleDOI
Corrigendum to “Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl) methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage” [ J. Control. Release. 174 (2014) 81–87]
Hideaki Nakamura,Tomáš Etrych,Petr Chytil,Manami Ohkubo,Jun Fang,Karel Ulbrich,Hiroshi Maeda +6 more
TL;DR: Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl) methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage are studied.
Journal ArticleDOI
Hydrophobic interactions between the secondary structures on the molecular surface reinforce the alkaline stability of serine protease.
TL;DR: The region of the initial unfolding of hyper-alkaline-sensitive subtilisin, ALP I, that precedes the denaturation of the entire protein under highly alkaline conditions was determined and alkaline stability of this region was most effectively improved by hydrophobic interactions, followed by ionic interactions with Arg residues.
Journal ArticleDOI
In Situ Observations of the Growth Process of C-Axis-Oriented Bi2Sr2Ca1Cu2Ox Superconducting Phase
Tsuginori Hasebe,Yoshiaki Tanaka,Tomoyuki Yanagiya,Toshihisa Asano,Masao Fukutomi,Hiroshi Maeda +5 more
TL;DR: In this paper, the growth process of the highly oriented microstructure of Bi2Sr2Ca1Cu2Ox(2212) crystalline phase has been studied by a method of in situ high-temperature microscopy.
Patent
Antiradicals and fat compositions, foods, drinks, drugs or feeds containing the antiradicals
Shigeru Morimura,Kenji Kida,Hiroshi Maeda,Fumi Yasuda,Daisuke Wakamatsu,Jun Tsunehiro,Chiaki Nakai +6 more
TL;DR: In this paper, the authors proposed a method to obtain highly active and fat-soluble antiradicals originating in a natural substance whereby the stability of foods (fat compositions) can be elevated and disorders caused by oxidation in vivo can be prevented simultaneously.
Journal Article
Inhibition of mite protease (Df-protease) with protease inhibitors.
TL;DR: To prevent the formation of kinin by the mite-protease, inhibition of the protease with its inhibitors was tested in vitro and in vivo and enhancement of blood permeability in guinea pigs caused by the prote enzyme was markedly suppressed by these inhibitors.