F
Fana Alemseged
Researcher at Royal Melbourne Hospital
Publications - 40
Citations - 1315
Fana Alemseged is an academic researcher from Royal Melbourne Hospital. The author has contributed to research in topics: Medicine & Modified Rankin Scale. The author has an hindex of 10, co-authored 23 publications receiving 613 citations. Previous affiliations of Fana Alemseged include University of Melbourne & University of Rome Tor Vergata.
Papers
More filters
Journal ArticleDOI
Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.
Michael D. Hill,Mayank Goyal,Bijoy K Menon,Raul G. Nogueira,Ryan A McTaggart,Andrew M. Demchuk,Alexandre Y Poppe,Brian H Buck,Thalia S Field,Dar Dowlatshahi,Brian van Adel,Richard H. Swartz,Ruchir Shah,Eric Sauvageau,Charlotte Zerna,Johanna M. Ospel,Manish Joshi,Mohammed A. Almekhlafi,Karla J Ryckborst,M.W. Lowerison,Kathy Heard,David Garman,Diogo C Haussen,Shawna Cutting,Shelagh B. Coutts,Daniel Roy,Jeremy L Rempel,A. Rohr,Daniela Iancu,Daniela Iancu,Demetrios J Sahlas,Amy Y.X. Yu,Thomas Devlin,Ricardo A. Hanel,Volker Puetz,F L Silver,Bruce C.V. Campbell,René Chapot,Jeanne Teitelbaum,Jennifer L Mandzia,Timothy Kleinig,David Turkel-Parrella,Donald V. Heck,Michael E Kelly,Aditya Bharatha,Oh Young Bang,Ashutosh P Jadhav,Rishi Gupta,Donald Frei,Jason W Tarpley,Cameron G. McDougall,Staffan Holmin,Joung-Ho Rha,Ajit S Puri,Marie-Christine Camden,Götz Thomalla,Hana Choe,Stephen J Phillips,Joseph L Schindler,John Thornton,Simon Nagel,Ji Hoe Heo,Sung Il Sohn,Marios-Nikos Psychogios,Ronald F Budzik,Sidney Starkman,C Martin,Paul A Burns,Sean M. Murphy,George A Lopez,Joey English,Michael Tymianski,Andrew M. Demchuk,Philip A. Barber,Eric E. Smith,Simerpreet Bal,Suresh Subramaniam,Steven Peters,Phillippe Couillard,Gary Klein,Peter Stys,Bijoy K. Menon,S B Coutts,Mohammed A Almekhlafi,Michael D. Hill,John Wong,Alim P. Mitha,Muneer Eesa,William Morrish,Saad Alqatani,Nima Kashani,Johanna Ospel,Prasanna Venkatesan,Erika Teleg,Amith Sitaram,Brett H. Graham,Stephen van Gaal,Aimen Moussaddy,Debabrata Chakraborty,Nicholas Maraj,Andrew Loockey,Shuo Chen,Ravinder Singh,Abdulaziz Alsultan,Ria Asuncion,Dominic Tse,Darshan Doshi,Ondrej Volny,Piyush Ojha,Ankur Wadhwa,Martha Marko,Nishita Singh,Sanchea Wasyliw,Karla J Ryckborst,Carol Kenney,Supriya Save,Anitha Jambula,Nancy Newcommon,Gavin Hull,Darcy Blackstock,Sharon Kiszczak,Leslie Zimmel,Michelle F. Wright,Cari Jahraus,Linda B. Andersen,Shelly Bohn,Joseph Paul,Oiao Zhang,Craig Doram,Mark Lowerison,Andrea Hanley,Lori Campbell,Ashley Ure,Francis Taylor,Dominic Hul,Samuel Wiebe,Marina Saluzzi,Nicole Blenkin,Richard Frayne,Brian Buck,Kenneth Butcher,Ashfaq Shuaib,Thomas Jeerakathil,Glen C. Jickling,Derek Emery,Jeremy L. Rempel,Richard Owen,Robert Ashforth,Tom Yeo,Trevor Kotylak,Cian O'Kelly,Michael Chow,Muzaffer Siddiqui,Maher Saqqur,Atlantic D’Souza,Mar Lloret,Asif Butt,Ali Zohair Nomani,Hayrapet Kalashyan,Sibi Thirunavukkarasu,Juline Jabs,Paige Fairall,Lori Piquette,Stephen J. Phillips,A. Laine Green,Gordon Gubitz,Jens Heidenreich,Thien J. Huynh,Jai Jai Shiva Shankar,William Maloney,Robert Vandorpe,Matthias H. Schmidt,Gwynedd E. Pickett,Adrienne Weeks,Judith Jarrett,Debbie MacDonald,Joanna Arsenault,Ruth Kinnear,Jennifer Mandzia,Michael Mayich,Melfort Boulton,Maria Bullrich,Sebastian Fridman,Ruba Kiwan,Donald H. Lee,Stephen Lownie,Alexander V. Khaw,Sachin Pandey,Manas Sharma,Luciano A. Sposato,Kevin Wade,Beth Beauchamp,Lindsay Lambourn,Belinda Amato-Marziali,Alexandre Y Poppe,Nicole Daneault,Yan Deschaintre,Laura C. Gioia,Grégory Jacquin,Céline Odier,Christian Stapf,Jean Raymond,Alain Weill,Marlène Lapierre,Nadia Jadil,Judlène Jolteus,Mark Angle,Mathew Hannouche,Mohamed K. Badawy,Justin Letourneau,Maria Cortes,Grant Linnell,Donateela Tampieri,Lucy Vieira,Catherine Legault,Liam Durcan,Angela Moore,Erin Cole,Claire Magnussen,Kristiana Salmon,Salma Khalil,Isabelle Desloges,Lindsay Waxman,Wynne Abdon,Sonia Lai,Michel Shamy,Grant Stotts,Dylan Blacquiere,Howard Lesiuk,Aiman Quateen,Brian Drake,Brian Dewar,Zeinab Daham,Michael Kelly,Gary R. Hunter,Lissa Peeling,Ruth Whelan,Aaron Garner,Lilian Urroz,Sharleen Maley,Frank L. Silver,Leanne K. Casaubon,Aleksandra Pikula,M. Campo,Joanna D. Schaafsma,Cheryl Jaigobin,Timo Krings,Vitor Mendes Pereira,Ronit Agid,Richard I. Farb,Libby Kalman,Anne Cayley,Janice Williams,Tim Stewart,Karen Misquitta,Daniel Selchen,Thomas R. Marotta,Dipanka Sarma,Walter Montanera,Juluan Spears,Gustavo Saposnik,Pawel Kostyrko,Yangmei Li,Carmen Parra-Farina,Jose Danilo B. Diestro,Steve Verreault,Ariane Mackey,Marie-Eve Audet,Geneviève Milot,Pascale Lavoie,Jean-Luc Gariépy,Karine Collard,Annette Haché,Brian Van Adel,Demetrios J. Sahlas,Ahmed Alshanbari,Josephine Baldwin,Luciana Catanese,Bing Chen,Danielle de Sa Boasquevisque,Aviraj Deshmukh,Jordan Knapman,Shana Lamers,Ramiro Larrazabal,Susan MacMillan,Lauren Mai,Alicia Mattia,Sumiti Nayar,Kuan Ng,Wieslaw Oczkowski,Kanjana S Perera,Mays Shawawrah,Ashkan Shoamanesh,Gita Sobhi,Nabeel Syed,Noran Taher,Cheyanne Vandervelde,Di Wang Pharm,Thalia S. Field,Philip Teal,Oscar R. Benavente,Laura A. B. Wilson,Sharanpal Mann,Samuel Yip,Colleen Murphy,Manraj K.S. Heran,Axel Rohr,Fabio Settecase,Gary Redekop,Charles S. Haw,Genoveva Maclean,Karina Murray,Rosalin Chiu,Alana M. Flexman,Eilidh Strecha,Yolanda Gayton,Judy Yip,Richard Swartz,Mark I. Boulos,David J. Gladstone,Amy Yu,Julia Hopyan,Houman Khosravani,Herbert Manosalva Alzate,Alisia Southwell,Maneesha Kamra,Kaitlyn Lopes,Arunima Kapoor,Leodante da Costa,Victor X. D. Yang,Erin Dyer,Ruchir Shah,Brenda Knowles,Jennifer Nichols,Jennifer Patterson,Krista Cope,Lee Dickerson,Katrina Barton,Kimberly Gray,Ticey Massengale,Melanie Miller,Cindy Simpson,Sabrina Walker,Chlin Tennyson-Yemm,Thomas Devlin,Donald Frei,R Bellon,Benjamin Atchie,Ian Kaminsky,Duandelyn Wilson,Nicolle Schraeder,Eric Arias,Lisa Kodis,Mark Talley,Alex Edinger,Tiffany Talley,Ita Dempsey,Laurie Williams,Scott Williams,Sonny Kupniewski,Brad Fasbinder,Joanna Snead,Larami MacKenzie,Davi Weisman,Osman Kozak,Qaisar A. Shah,Dan Gzesh,Kandan Kulandaivel,John Khoury,Brad Klein,Patricia Bussinger,Lisa Griffin,Ashley dePalmo,Cynthia Oliva,Tudor G Jovin,Cynthia L. Kenmuir,Brian T. Jankowitz,Bradley A. Gross,Marcelo Rocha,Matthew Starr,Merritt Brown,Christine Hawkes,Kavit Shah,Danoushka Tememe,Gregory Walker,Pratit Patel,Bradley Klein,Habibullah Ziayee,Kaustubh Limaye,Lisa Baxendell,Vicki Gilchrist,Patricia Feineigle,Kelsea Toseki Haibach,Cathy Van Every,Shashyat Desai,Maryam Zulfiqar,Linda Gibson,Sean Barrett,Karthikeyan Arcot,Steven DiCrescento,Jeffrey Farkas,Gregory Filipowski,Jennifer A. Frontera,Danielle Joset,Jeremy Liff,Erica Scher,Cameron M. McDougall,Cheryl Kelly,Akshal Patel,Stephen J. Monteith,Kunakorn Atchaneeyasakul,Adrian Burgos,Janice Anne Chua,Nathan Gaines,Ileana Grunberg,Judy Guzy,Zuolu Liu,Neil Maluste,Lucas Ramirez,Latisha Sharma,Morry Brown,Colin McDonald,Mateo Calderon,Mitch Hargis,Christina Roels,Prabhu Emmady,Talat Alvi,Ryan A McTaggart,Mahesh V Jayaraman,Shawna S. Cutting,Wendy Smith,Susan Foley,Gino Paolucci,Richard Has,Katie Quinn,Lindsey Fuller,Rebecca Brierley,Christina Watkins,Nicole Demir,George A. Lopez,Alejandro Vargas,Nicholas Osteraas,Becky Holtz,Ricardo Hanel,Amin Aghaebrahim,Mohamad Chmayssani,Neeraj Naval,Jason Day,Scott Dellorso,Benjamin Ludwig,Derek Schemmel,Nancy Ebreo,Karen Bell,Lanai Lewis,Marjorie Delucia,Raul G Nogueira,Michael Frankel,Nirav Bhatt,Nicolas Bianchi,Aaron Anderson,Samir Belagaje,Bernardo Liberato,Srikant Rangaraju,Alhamza R Al-Bayati,Jonathan A. Grossberg,Leah Craft,Kiva M Schindler,Erin Schaad,Meagan Schultz,Lorretta Southerly,Shannon Doppelheuer,Jacquelyn Charlton,Jason Faggard,Zuzana Barbret,Ethan DukSoo Han,Robin G. Walters,Jaydevsinh Dolia,Sleiman El-Jamal,Brendan Eby,Yasir Saleem,Harrison Pearl,Kishan Patel,Haseeb Rahman,Reema Butt,Stephen English,Ajit S. Puri,M Howk,Jasmeet Singh,Francesco Massari,Katyucia de Macedo Rodrigues,Anna Luisa Kühn,Nobl Barazangi,Nick Telischak,Warren Kim,Josh Ross,Nata DeVole,Jessica Redford,Milena Ferreira,Katie Ponting,Helen Shen,Ann Bedenk,Susila Patel,Julia Fernandess,Michael Ke,Ilanit Spokoyny,Billy Gao,David C. Tong,Charlene Chen,Christine Wong,Jessica Choe,Coleman O. Martin,Debbie Summers,Christine Boutwell,Karin Olds,Suzanne Crandall,John Eatman,Naveed Akhtar,William E. Holloway,Jared Halpin,Brett Donegan,Joseph Schindler,David Y. Hwang,Emily J. Gilmore,Nils H Petersen,Kevin N. Sheth,Stacy C Brown,Rachel Beekman,Benjamin George,Firas Kaddouh,Guido J. Falcone,Charles R. Wira,Charles C. Matouk,Caitlin Loomis,Hardik Amin,Hans Christoph Stretz,Reshma Narula,Adam Jasne,Lauren H Sansing,Tijil Agarwal,Sara Jasak,Briana Fontaine,Zachary A. King,Lindsey Kuohn,Hailey Orgass,Megan Leary,Joan Nye,Kelsey Halbert,Karin Nystrom,Kaile Neuschatz,Dawn Petrucci,Anna Coppola,Jason Tarpley,Treasure Joyce,Sam Hou,Mark Umekubo,Catrice Nakamura,Renee Ovando,Diana Zuniga,Yih Lin Nien,Fernando Mayor Basto,Allison Arch,Laura Jong,William Conrad,Tara Abbott,Jay Yao,Scott Caganap,John Jordan,George Teitelbaum,Robert Darflinger,Marianne Bain,Ronald F. Budzik,Jennifer Czerniak,Katherine Groezinger,William Hicks,Omran Kaskar,Brian Katz,Aaron Loochtan,Peter Pema,Vivek Rai,Nirav Vora,Amanda Brown,Diane Goodman,Barb Danenbergs,Monica Gossett,Jong-Won Chung,Pyoung Jeon,Keon Ha Kim,Yun Jeong Lim,Hyo Suk Nam,Young Dae Kim,Hyungjong Park,In Gun Hwang,Wooseok Ha,Jin Kyo Choi,Kyungsun Jeong,Hee-Kwon Park,Cindy Yoon,Bo-Kyung Kim,Chang-Hyun Kim,Joonsang Yoo,Jeong-Ho Hong,S.-H. Kim,Moonkyung Choi,Hyoeun Bae,Jun Seok Lee,Jae-Joon Lee,Go-Eun Jun,Sujeong Jeon,B Campbell,Peter Mitchell,Nawaf Yassi,Stephen N. Davis,Geoffrey A. Donnan,Mark W Parsons,Bernard Yan,Richard Dowling,Steven Bush,Teddy Y. Wu,Darshan Shah,Henry Zhao,Patrick Salvaris,Fana Alemseged,Felix C Ng,Cameron Williams,Anna H. Balabanski,Angela Dos Santos,Jo-Lyn Ng,Amy A. McDonald,David C. Jackson,Jessica Tsoleridis,Lauren Pesavento,Timothy John Kleinig,Roy Drew Nurs,Jennifer Cranefield,Rebecca Scroop,Lavenia Cagi,Jackson Harvey,Michael J. Waters,Robert Brennan,Alan O'Hare,Sarah Power,David Williams,Karl Boyle,Barry Moynihan,Ann-Marie Liddy,Margaret Large,Ailbhe Cullen,Roisin Walsh,Emma Martin,Julie Lynch,Sinéad McElroy,Sarah Coveney,Caroline Deegan,Gillian Horgan,Peter J. Kelly,Aoife Laffan,Yudy Llamas-Osorio,Catherine Lynch,Peter Mac Mahon,Michael Marnane,John Gerald McCabe,Paul A Burns,Suzanne Tauro,Sarah Cuddy,Ian Rennie,Graham Smyth,Peter Flynn,Ivan Wiggam,Enda Kerr,Patricia Gordon,Patricia Fearon,Geralt Roberts,Cathy Patterson,Karen Adams,Brian J. Wells,Margaret McFarland,Tiago Moreira,Christina Sjöstrand,Michael V. Mazya,Håkan Almqvist,Nils Wahlgren,Anna Steinberg,Charith Cooray,Einar E. Eriksson,Magnus Thorén,Boris Keselman,Niaz Ahmed,Åke Holmberg,Maria Axelsson,Annika Berglund,Amir Golsari,Julia Hoppe,Milani Deb-Chatterji,Bastian Cheng,Ewgenia Barrow,Eckhard Schlemm,Iris Lettow,Märit Jensen,Dagmar Otto,Kirsten Jaramillo,Hannes Appelbohm,Jens Fiehler,Maxim Bester,Michael Schönfeld,Caspar Brekenfeld,Brigitte Holst,Ginette Wortmann,Friederike Koch,Johannes Gerber,Andrij Abramyuk,Daniel Kaiser,Simon Winzer,Alexandra Prakapenia,Lars-Peder Pallesen,Timo Siepmann,Kristian Barlinn,Kathrin Haase,Angela Sauer,Jan Liman,Alex Brehm,Volker Maus,Nicole Hollstein,Annika Reinke,Gustav Neitz,Marlena Schnieder,Margret Schwarz,Allam Ibrahim,Julia Müller,Stefanie Meister,Berit Bäumle,Sara Pilgram-Pastor,Marta Wallocha,Michael Stauder,Ekin Celik,Paul Stracke,Nicole Müller,Ralph Weber,Roland Velktamp,Peter A. Ringleb,Miriam Heyse,Hemasse Amiri,Sibu Mundiyanapurath,Min Chen,Elisabeth Bevrle,Perdita Beck,Markus A Möhlenbruch,Alphonse Potvin,Cameron Harris,Chong Wang,Corey Adams,Diana Mayor,Dave Garman,Davis Chau,Jane Wu,Janet Lunn,Liat Bermanis,Lucy Teyes,Marc Constant,Maria Galsim,Michael Helbin,Michelle Leroux,Nicole Felix,Nilima Bendre,Sandra Cuthbert,Steve Brokx,Yichuan Zhang,Trudy Lingham,Yatika Kohli,Michael Salter,Joseph Liebeschuetz,Frieder Hofmann,John Constant,Tom Soeder,Kara Snoke,Monica Bologa,Kimberly Stahl,Maria Graziewicz +776 more
TL;DR: Nerinetide did not improve the proportion of patients achieving good clinical outcomes after endovascular thrombectomy compared with patients receiving placebo, and this trial is registered with ClinicalTrials.gov, NCT02930018.
Journal ArticleDOI
Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data
Bruce C.V. Campbell,Bruce C.V. Campbell,Henry Ma,Henry Ma,Peter A. Ringleb,Mark W Parsons,Leonid Churilov,Martin Bendszus,Christopher R Levi,Chung Hsu,Timothy Kleinig,Marc Fatar,Didier Leys,Carlos A. Molina,Tissa Wijeratne,Sami Curtze,Helen M Dewey,P. Alan Barber,Kenneth Butcher,Kenneth Butcher,Deidre A De Silva,Christopher F. Bladin,Christopher F. Bladin,Nawaf Yassi,Nawaf Yassi,Johannes Pfaff,Gagan Sharma,Andrew Bivard,Patricia Desmond,Stefan Schwab,Peter D Schellinger,Bernard Yan,Peter Mitchell,Joaquín Serena,Danilo Toni,Vincent Thijs,Vincent Thijs,Werner Hacke,Stephen M. Davis,Geoffrey A. Donnan,Geoffrey A. Donnan,Thomas J Oxley,Teddy Y. Wu,Darshan Shah,Henry Zhao,Edrich Rodrigues,Patrick Salvaris,Fana Alemseged,Felix C Ng,Cameron Williams,Jo-Lyn Ng,Hans T.H. Tu,Amy A. McDonald,David C. Jackson,Jessica Tsoleridis,Rachael McCoy,Lauren Pesavento,Louise Weir,Sandy Patel,John T Harvey,Jeyaledchumy Mahadevan,E. Cheong,Anna H. Balabanski,Michael J. Waters,Roy Drew,Jennifer Cranefield,Elizabeth Mackey,Sherisse Celestino,Essie Low,Poh Sien Loh,Philip M.C. Choi,Skye Coote,Tanya Frost,K. Hogan,C. Ding,S. McModie,W.W. Zhang,Christopher Kyndt,A. Moore,Z. Ross,J. Liu,Ferdinand Miteff,Timothy Ang,Neil J. Spratt,Carlos Garcia-Esperon,Lara Kaauwai,Thanh G. Phan,John Ly,Shaloo Singhal,Benjamin Clissold,Kitty Wong,Martin Krause,Susan Day,Jonathan Sturm,Bill O'Brian,Rohan Grimley,Marion Simpson,Matthew Lee-Archer,Amy Brodtmann,Bronwyn Coulton,Dennis Young,Andrew Wong,Claire Muller,Deborah Field,Wilson Vallat,Vanessa Maxwell,Peter L. Bailey,Arman Sabet,Sachin Mishra,Meng Tan,K. George,L. Zhao,Atte Meretoja,Turgut Tatlisumak,Gerli Sibolt,Marjaana Tiainen,M. Koivu,Karoliina Aarnio,J. Virta,O. Kasari,S. Eirola,M.C. Sun,T.C. Chen,C.S. Chuang,Y.Y. Chen,C.M. Lin,S.C. Ho,P.M. Hsiao,C.H. Tsai,W.S. Huang,Y.W. Yang,H.Y. Huang,W.C. Wang,C.H. Liu,M.K. Lu,C.H. Lu,W.L. Kung,S.K. Jiang,Y.H. Wu,S.C. Huang,C.H. Tseng,L.T. Tseng,Y.C. Guo,D. Lin,C. T. Hsu,C.W. Kuan,J.P. Hsu,H.T. Tsai,M. Suzuki,Y. Sun,H.F. Chen,C.J. Lu,C.H. Lin,C.C. Huang,H.J. Chu,Cheryl Yi-Pin Lee,W.H. Chang,Y.C. Lo,Y.T. Hsu,C.H. Chen,P.S. Sung,C. L. Ysai,J.S. Jeng,S.C. Tang,Li-Kai Tsai,S.J. Yeh,Y.C. Lee,Y.T. Wang,T.C. Chung,C.J. Hu,L. Chan,Y.W. Chiou,L.M. Lien,H.L. Yeh,J.H. Yeh,W.H. Chen,C.L. Lau,A. Chang,I.Y. Lee,M.Y. Huang,J.T. Lee,G.S. Peng,J.C. Lim,Y.D. Hsu,C.C. Lin,C.A. Cheng,C.H. Yen,F.C. Yang,C.H. Hsu,Y.F. Sung,C.K. Tsai,C.L. Tsai,A. Lee,Graeme J. Hankey,David Blacker,Richard P. Gerraty,C-I. Chen,C-S. Hsu,Elise Cowley,Michele Sallaberger,Barry Snow,John Kolbe,Richard J Stark,John King,Richard Macdonnell,John Attia,Catherine D'Este,Julie Bernhardt,Leeanne M. Carey,Dominique A Cadilhac,Craig S. Anderson,David W. Howells,Alan Barber,Alan Connelly,Malcolm R. Macleod,Victoria E O'Collins,William Wilson,Lance Macaulay,Erich Bluhmki,Christoph C. Eschenfelder,Peter A. Ringleb,Peter D. Schellinger,Nils Wahlgren,Joanna M. Wardlaw,Catherine Oppenheim,Kennedy R. Lees,Markku Kaste,Rüdiger von Kummer,Gilles Chatellier,Rico Laage,Xavier Nuñez,Christina Ehrenkrona,Ann-Sofie Svenson,Lynda Cove,Kurt Niederkorn,Franz Gruber,Peter Kapeller,Robert Mikulik,Jean-Louis Mas,Jörg Berrouschot,Jan Sobesky,Martin Köhrmann,Thorsten Steiner,Christof Kessler,Rainer Dziewas,Sven Poli,Katharina Althaus-Knaurer,Paolo Bovi,Alain Luna Rodriguez,Juan F. Arenillas,Keith W. Muir,Roland Veltkamp,Anand Dixit,Girish Muddegowda,Lalit Kala,Graham Byrnes,André Peeters,J. Chalk,John N. Fink,Thomas E. Kimber,David Schultz,Peter J. Hand,Judith Frayne,Brian M. Tress,John J McNeil,R. Burns,C. Johnston,Michael Williams +267 more
TL;DR: Patients with ischaemic stroke 4·5-9 h from stroke onset or wake-up stroke with salvageable brain tissue who were treated with alteplase achieved better functional outcomes than did patients given placebo, and this increase in the rate of symptomatic intracerebral haemorrhage did not negate the overall net benefit of thrombolysis.
Journal ArticleDOI
Effect of intravenous tenecteplase dose on cerebral reperfusion before thrombectomy in patients with large vessel occlusion ischemic stroke: the EXTEND-IA TNK Part 2 randomized clinical trial
Bruce C.V. Campbell,Bruce C.V. Campbell,Peter Mitchell,Leonid Churilov,Leonid Churilov,Leonid Churilov,Nawaf Yassi,Nawaf Yassi,Nawaf Yassi,Timothy Kleinig,Richard Dowling,Bernard Yan,Steven Bush,Vincent Thijs,Vincent Thijs,Rebecca Scroop,Marion Simpson,Mark Brooks,Hamed Asadi,Hamed Asadi,Hamed Asadi,Teddy Y. Wu,Darshan Shah,Tissa Wijeratne,Henry Zhao,Fana Alemseged,Felix C Ng,Peter L. Bailey,Henry E. Rice,Laetitia de Villiers,Helen M Dewey,Philip M. C. Choi,Helen Brown,Kendal Redmond,David Leggett,John N. Fink,Wayne Collecutt,Thomas Kraemer,Martin Krause,Dennis Cordato,Deborah Field,Henry Ma,Bill O'Brien,Benjamin Clissold,Ferdinand Miteff,Anna Clissold,Geoffrey Cloud,Leslie E. Bolitho,Luke Bonavia,Arup Bhattacharya,Alistair Wright,Abul Mamun,Fintan O'Rourke,John M. Worthington,Andrew Wong,Christopher Levi,Christopher F. Bladin,Christopher F. Bladin,Christopher F. Bladin,Gagan Sharma,Patricia Desmond,Mark W Parsons,Geoffrey A. Donnan,Stephen M. Davis +63 more
TL;DR: Among patients with large vessel occlusion ischemic stroke, a dose of 0.40 mg/kg of tenecteplase did not significantly improve cerebral reperfusion prior to endovascular thrombectomy, and the findings suggest that the0.40-mg/kg dose ofTenecte Plase does not confer an advantage over the 0.25-mg-kg dose.
Journal ArticleDOI
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
Götz Thomalla,Florent Boutitie,Henry Ma,Masatoshi Koga,Peter A. Ringleb,Lee H. Schwamm,Ona Wu,Martin Bendszus,Christopher F. Bladin,Bruce C.V. Campbell,Bastian Cheng,Leonid Churilov,Martin Ebinger,Martin Ebinger,Matthias Endres,Jochen B. Fiebach,Mayumi Fukuda-Doi,Manabu Inoue,Timothy Kleinig,Lawrence L. Latour,Robin Lemmens,Robin Lemmens,Christopher R Levi,Didier Leys,Kaori Miwa,Carlos A. Molina,Keith W. Muir,Norbert Nighoghossian,Mark W Parsons,Salvador Pedraza,Peter D. Schellinger,Stefan Schwab,Claus Z Simonsen,Shlee S. Song,Vincent Thijs,Vincent Thijs,Danilo Toni,Chung Y. Hsu,Nils Wahlgren,Haruko Yamamoto,Nawaf Yassi,Nawaf Yassi,Sohei Yoshimura,Steven Warach,Werner Hacke,Kazunori Toyoda,Geoffrey A. Donnan,Stephen M. Davis,Christian Gerloff,Boris Raul Acosta,Karen Aegidius,Christian Albiker,Anna Alegiani,Miriam Almendrote,Angelika Alonso,Katharina Althaus,Pierre Amarenco,Hemasse Amiri,Bettina Anders,Adriana Aniculaesei,Jason P. Appleton,Juan F. Arenillas,Christina Back,Christian Bähr,Jürgen Bardutzky,Flore Baronnet-Chauvet,R. Bathe-Peters,Anna Bayer-Karpinska,Juan L. Becerra,Christoph Beck,Olga Belchí Guillamon,Amandine Benoit,Nadia Berhoune,Daniela Bindila,Julia Birchenall,Karine Blanc-Lasserre,Miguel Blanco Gonzales,Tobias Bobinger,Ulf Bodechtel,E Bodiguel,Urszula Bojaryn,Louise Bonnet,Benjamin Bouamra,Paul Bourgeois,Lorenz Breuer,Ludovic Breynaert,David Broughton,Raf Brouns,Sébastian Brugirard,Bart Bruneel,Florian Buggle,Serkan Cakmak,Ana Calleja,David Calvet,David Carrera,Hsin Chieh Chen,Bharath Kumar Cheripelli,Tae Hee Cho,Chi un Choe,Lillian Choy,Hanne Christensen,Mareva Ciatipis,Geoffrey Cloud,Julien Cogez,Elisa Cortijo,Sophie Crozier,Dorte Damgaard,Krishna A Dani,Beatrijs De Coene,Isabel De Hollander,Jacques De Keyser,Nina De Klippel,Charlotte De Maeseneire,Ann De Smedt,Maria del Mar Castellanos Rodrigo,Sandrine Deltour,Jelle Demeestere,Laurent Derex,Philippe Desfontaines,Ralf Dittrich,Anand Dixit,Laurens Dobbels,V. Domigo,Laura Dorado,Charlotte Druart,Kristina Hougaard Dupont,Anne Dusart,Rainer Dziewas,Matthias Ebner,Myriam Edjali-Goujon,Philipp Eisele,Salwa El Tawil,Ahmed Elhfnawy,Ana Etexberria,Nick Evans,Simon Fandler,Franz Fazekas,Sandra Felix,Jens Fiehler,Alexandra Filipov,Katharina Filipski,Robert Fleischmann,Christian Foerch,Ian Ford,Alexandra Gaenslen,Ivana Galinovic,Elena Meseguer Gancedo,Ramanan Ganeshan,Carlos Garcia Esperon,Alicia Garrido,Thomas Gattringer,Olivia C. Geraghty,Rohat Geran,Stefan Gerner,S. Godon-Hardy,Jos Göhler,Amir Golsari,Meritxell Gomis,David Gorriz,Verena Gramse,Laia Grau,Martin Griebe,Cristina Guerrero,Damla Guerzoglu,Sophie Guettier,Vincent Guiraud,Christoph Gumbinger,Ignaz Gunreben,Florian Haertig,Christian Hametner,Bernard Hanseeuw,Andreas Hansen,Jakob Hansen,Thomas Harbo,Andreas Harloff,Peter Harmel,Karl Georg Häusler,Florian Heinen,Valentin Held,Simon Hellwig,Dimitri Hemelsoet,Michael G. Hennerici,Juliane Herm,Sylvia Hermans,Maria del C. Valdés Hernández,Jose Hervas Vicente,Niels Hjort,Cristina Hobeanu,Carsten Hobohm,Elmar Höfner,Katharina Hohenbichler,Marc Hommel,Julia Hoppe,Eva Hornberger,Carolin Hoyer,Xuya Huang,Nils Ipsen,Irina Isern,Lourdes Ispierto,Helle K. Iversen,Lise Jeppesen,Marta Jimenez,Jan Jungehülsing,Eric Jüttler,Dheeraj Kalladka,Bernd Kallmünzer,Arindam Kar,Lars Kellert,André Kemmling,Tobias Kessler,Usman A. Khan,Matthias Klein,Christoph Kleinschnitz,Matti Klockziem,Michael Knops,Luzie Koehler,Martin Koehrmann,Heinz Kohlfürst,Rainer Kollmar,Peter Kraft,Thomas Krause,Bo Kristensen,Jan M Kröber,Natalia Kurka,Alexandre Ladoux,Patrice Laloux,Catherine Lamy,Emmanuelle Landrault,Arne Lauer,Claire Lebely,Jonathan Leempoel,Kennedy R. Lees,Anne Leger,Laurence Legrand,Lin Li,Anna Mareike Löbbe,Frederic London,Elena López-Cancio,Matthias W. Lorenz,Stephen Louw,Caroline E. Lovelock,Manuel Lozano Sánchez,Giuseppe Lucente,Janos Lückl,Alain Luna,Kosmas Macha,Alexandre Machet,Daniel Mackenrodt,Dominik Madzar,Charles B. L. M. Majoie,Anika Männer,Vicky Maqueda,Jacob Marstrand,Alicia Martinez,Annika Marzina,Laura Mechthouff,Per Meden,Guy Meersman,Julia Meier,Charles Mellerio,Oliver Menn,Nadja Meyer,Dominik Michalski,Peter Michels,Lene Michelsen,Monica Millán Torne,Jens Minnerup,Boris Modrau,Sebastian Moeller,Anette Møller,Nathalie Morel,Fiona Moreton,Ludovic Morin,Thierry Moulin,Barry Moynihan,Anne K. Mueller,Patricia Mulero,Sibu Mundiyanapurath,Johannes Mutzenbach,Simon Nagel,Oliver Naggara,Arumugam Nallasivan,Irene Navalpotro,Alexander H. Nave,Paul J. Nederkoorn,Lars Neeb,Hermann Neugebauer,Tobias Neumann-Haefelin,Stefan Oberndorfer,Christian Opherk,Lorenz Oppel,Catherine Oppenheim,Johannes Orthgieß,Leif Østergaard,Perrine Paindeville,Ernest Palomeras,Verena Panitz,Bhavni Patel,André Peeters,Dirk Peeters,Anna Pellisé,Johann Pelz,Anthony C Pereira,Natalia Pérez de la Ossa,Richard J. Perry,Salvador Petraza,Stéphane Peysson,Waltraud Pfeilschifter,Alexander Pichler,Alexandra Pierskalla,Hans Werner Pledl,Sven Poli,Katrin Pomrehn,Marika Poulsen,Luis Prats,Silvia Presas,Elisabeth Prohaska,Volker Puetz,Josep Puig,Josep Puig Alcántara,Jan C. Purrucker,Veronique Quenardelle,Sankaranarayanan Ramachandran,Soulliard Raphaelle,Nicolas Raposo,Tilman Reiff,Michel J M Remmers,Pauline Renou,Martin Ribitsch,Hardy Richter,Martin Ritter,Thomas Ritzenthaler,Gilles Rodier,Christine Rodriguez-Régent,Manuel Rodríguez-Yáñez,Maria Roennefarth,Christine Roffe,Sverre Rosenbaum,Charlotte Rosso,Joachim Röther,Michal Rozanski,Noelia Ruiz de Morales,Francesca Russo,Matthieu Rutgers,Sharmilla Sagnier,Yves Samson,Josep Sánchez,Tamara Sauer,Jan H. Schäfer,Simon Schieber,Josef Schill,Dennis Schlak,Ludwig Schlemm,Sein Schmidt,Wouter J. Schonewille,Julian Schröder,Andreas Schulz,Johannes Schurig,Sönke Schwarting,Alexander Schwarz,Christopher Schwarzbach,Matthias Seidel,Alexander Seiler,Jochen Sembill,Joaquin Serena Leal,Ashit Shetty,Igor Sibon,Oliver C. Singer,Aravinth Sivagnanaratham,Ide Smets,Craig J. Smith,Peter Soors,Nikola Sprigg,Maximilian Spruegel,David Stark,Susanne Steinert,Sebastian Stösser,Markus Stuermlinger,Bart Swinnen,Ruben Tamazyan,Jose Tembl,Mikel Terceno Izaga,Emmanuel Touzé,Thomas Truelsen,Guillaume Turc,Gaetane Turine,Serdar Tütüncü,Pippa Tyrell,Xavier Ustrell,Wilfried Vadot,Anne Evelyne Vallet,Pauline Vallet,Lucie A. van den Berg,Sophie A. van den Berg,Cecile van Eendenburg,Robbert Jan Van Hooff,Isabelle van Sloten,Peter Vanacker,Evelien Vancaester,Patrick Vanderdonckt,Yves Vandermeeren,Frederik Vanhee,Roland Veltkamp,Karsten Vestergaard,Alain Viguier,Dolores Vilas,Kersten Villringer,Dieke Voget,Jörg von Schrader,Paul von Weitzel,Elisabeth Warburton,Claudia Weber,Jörg Weber,Karl Wegscheider,Mirko Wegscheider,Christian Weimar,Karin Weinstich,Christopher Weise,Gesa Weise,Chris Willems,Klemens Winder,Matthias Wittayer,Marc Wolf,Martin Wolf,Valerie Wolff,Christian Wollboldt,Frank A. Wollenweber,Anke Wouters,Bertrand Yalo,Marion Yger,Nadia Younan,Laetita Yperzeele,Vesna Zegarac,Pia Zeiner,Ulf Ziemann,Thomas P. Zonneveld,Mathieu Zuber,Tsugio Akutsu,Junya Aoki,Shuji Arakawa,Ryosuke Doijiri,Yusuke Egashira,Yukiko Enomoto,Eisuke Furui,Konosuke Furuta,Seiji Gotoh,Toshimitsu Hamasaki,Yasuhiro Hasegawa,Teryuki Hirano,Kazunari Homma,Masahiko Ichijyo,Toshihiro Ide,Shuichi Igarashi,Yasuyuki Iguchi,Masafumi Ihara,Hajime Ikenouchi,Tsuyoshi Inoue,Ryo Itabashi,Yasuhiro Ito,Toru Iwama,Kenji Kamiyama,Shoko Kamiyoshi,Haruka Kanai,Yasuhisa Kanematsu,Takao Kanzawa,Kazumi Kimura,Jiro Kitayama,Takanari Kitazono,Rei Kondo,Kohsuke Kudo,Masayoshi Kusumi,Ken Kuwahara,Shoji Matsumoto,Hideki Matsuoka,Ban Mihara,Kazuo Minematsu,Ken Miura,Naomi Morita,Wataru Mouri,Kayo Murata,Yoshinari Nagakane,Taizen Nakase,Hiromi Ohara,Nobuyuki Ohara,Hideyuki Ohnishi,Hajime Ohta,Masafumi Ohtaki,Ryo Ohtani,Toshiho Ohtsuki,Hideo Ohyama,Takashi Okada,Yasushi Okada,Masato Osaki,Nobuyuki Sakai,Yoshiki Sanbongi,Naoshi Sasaki,Makoto Sasaki,Shoichiro Sato,Kenta Seki,Wataru Shimizu,Yoshiaki Shiokawa,Takashi Sozu,Junichiro Suzuki,Rieko Suzuki,Yasushi Takagi,Shunya Takizawa,Norio Tanahashi,Eijiro Tanaka,Ryota Tanaka,Yohei Tateishi,Tomoaki Terada,Tadashi Terasaki,Kenichi Todo,Azusa Tokunaga,Akira Tsujino,Toshihiro Ueda,Yoshikazu Uesaka,Mihoko Uotani,Takao Urabe,Masao Watanabe,Yoshiki Yagita,Yusuke Yakushiji,Keizo Yasui,Toshiro Yonehara,Shinichi Yoshimura,Karoliina Aarnio,Fana Alemseged,Craig S. Anderson,T. Ang,M. L. Archer,John Attia,Peter L. Bailey,Anna H. Balabanski,Alan Barber,P A Barber,Julie Bernhardt,Andrew Bivard,Deborah Blacker,C. F. Bladin,Amy Brodtmann,Dominique A Cadilhac,Leeanne M. Carey,Sherisse Celestino,L. Chan,W. H. Chang,A. ChangI,C. H. Chen,C. I. Chen,H. F. Chen,T. C. Chen,W. H. Chen,Y. Y. Chen,C. A. Cheng,E. Cheong,Y. W. Chiou,Philip M.C. Choi,H. J. Chu,C. S. Chuang,T. C. Chung,L. Churilov,Benjamin Clissold,Alan Connelly,Skye Coote,Bronwyn Coulton,Elise Cowley,Jennifer Cranefield,Sami Curtze,Cate D'Este,S. M. Davis,Susan Day,Patricia Desmond,H Dewey,C. Ding,Roy Drew,S. Eirola,Deborah Field,Tanya Frost,Carlos Garcia-Esperon,K. George,Richard P. Gerraty,R. Grimley,Y. C. Guo,Graeme J. Hankey,John T Harvey,S. C. Ho,K. Hogan,David W. Howells,P. M. Hsiao,Chung Hsu,C. T. Hsu,C. S. Hsu,J. P. Hsu,Y. D. Hsu,Y. T. Hsu,C. J. Hu,C. C. Huang,H. Y. Huang,M. Y. Huang,S. C. Huang,W. S. Huang,David C. Jackson,J. S. Jeng,S. K. Jiang,Lara Kaauwai,O. Kasari,J. King,M. Koivu,John Kolbe,Martin Krause,C. W. Kuan,W. L. Kung,C. Kyndt,C. L. Lau,A. Lee,Cheryl Yi-Pin Lee,J. T. Lee,Y. Lee,Y. C. Lee,Christopher Levi,C. R. Levi,L. M. Lien,J. C. Lim,C. C. Lin,C. H. Lin,C. M. Lin,D. Lin,C. H. Liu,J. Liu,Y. C. Lo,P. S. Loh,Essie Low,C. H. Lu,C. J. Lu,M. K. Lu,J. Ly,Lance Macaulay,Richard Macdonnell,Elizabeth Mackey,Malcolm R. Macleod,Jeyaledchumy Mahadevan,Vanessa Maxwell,Rachael McCoy,Amy A. McDonald,S. McModie,Atte Meretoja,Shiva Raj Mishra,Peter Mitchell,Ferdinand Miteff,A. Moore,Claire Muller,F. Ng,F. C. Ng,J. L. Ng,W. O'Brian,Victoria E O'Collins,Thomas J Oxley,Sandy Patel,G. S. Peng,Lauren Pesavento,T. Phan,Edrich Rodrigues,Z. Ross,Arman Sabet,M. Sallaberger,Patrick Salvaris,Darshan Shah,Gagan Sharma,Gerli Sibolt,Marion Simpson,Shaloo Singhal,Barry Snow,Neil J. Spratt,Richard J Stark,Jonathon Sturm,M. C. Sun,Y. Sun,P. S. Sung,Y. F. Sung,M. Suzuki,M. Tan,S. C. Tang,Turgut Tatlisumak,V. Thijs,V. Thijs,Marjaana Tiainen,C. H. Tsai,C. K. Tsai,C. L. Tsai,H. T. Tsai,L. K. Tsai,C. H. Tseng,L. T. Tseng,Jessica Tsoleridis,H. Tu,H. T.H. Tu,Wilson Vallat,J. Virta,W. C. Wang,Y. T. Wang,Michael J. Waters,Louise Weir,Tissa Wijeratne,Cylie Williams,William Wilson,A. A. Wong,K. Wong,T. Y. Wu,Y. H. Wu,B. Yan,F. C. Yang,Y. W. Yang,N. Yassi,N. Yassi,H. L. Yeh,J. H. Yeh,S. J. Yeh,C. H. Yen,D. Young,C. L. Ysai,W. W. Zhang,Henry Zhao,L. Zhao,Katharina Althaus-Knaurer,Jörg Berrouschot,Erich Bluhmki,Paolo Bovi,Gilles Chatellier,Lynda Cove,Stephen M. Davis,A. Dixit,Christina Ehrenkrona,Christoph C. Eschenfelder,Marc Fatar,Juan F. Arenillas,Franz Gruber,Lalit Kala,Peter Kapeller,Markku Kaste,Christof Kessler,Martin Köhrmann,Rico Laage,Kennedy R. Lees,Alain Luna Rodriguez,Jean-Louis Mas,Robert Mikulik,Carlos A. Molina,Girish Muddegowda,Kurt Niederkorn,Xavier Nuñez,Joaquín Serena,Jan Sobesky,Thorsten Steiner,Ann Sofie Svenson,Rüdiger von Kummer,Joanna M. Wardlaw,Rebecca A. Betensky,Gregoire Boulouis,Raphael A. Carandang,William A. Copen,Pedro Cougo,Shawna Cutting,Kendra Drake,Andria L. Ford,John Hallenbeck,Gordon J. Harris,Robert Hoesch,Amie Hsia,Carlos S. Kase,Lawrence L. Latour,Michael H. Lev,Alona Muzikansky,Nandakumar Nagaraja,Eric Searls,Sidney Starkman,Albert J Yoo,Ramin Zand +775 more
TL;DR: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care despite an increased risk of symptomatic intracranial haemorrhage.
Journal ArticleDOI
The Basilar Artery on Computed Tomography Angiography Prognostic Score for Basilar Artery Occlusion.
Fana Alemseged,Darshan Shah,Marina Diomedi,Fabrizio Sallustio,Andrew Bivard,Gagan Sharma,Peter Mitchell,Richard Dowling,Steven Bush,Bernard Yan,Carlo Caltagirone,Roberto Floris,Mark W Parsons,Christopher R Levi,Stephen M. Davis,Bruce C.V. Campbell +15 more
TL;DR: The addition of collateral quality to clot burden in BATMAN score seems to improve prognostic accuracy in basilar artery occlusion patients.