Sherman M. Weissman

TL;DR: The mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types as mentioned in this paper.

TL;DR: By comparing with the human genome, this work not only confirms substantial conservation in the newly annotated potential functional sequences, but also finds a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization.

TL;DR: In this paper, the authors used RNA interference (RNAi) to knockdown WRN or BLM (the RecQ helicase mutated in Bloom syndrome) expression in primary human fibroblasts.

TL;DR: Investigation of how the large deletion CNV on chromosome 22q11.2 alters chromatin organization suggests basic principles of how such large genomic deletions can alter nuclear organization and affect genomic molecular activity are suggested.

TL;DR: Effects of cell cycle progression on the expression of lineage specific genes in precursor cells are revealed, and it is suggested that hematopoietic stress changes the balance of renewal and differentiation in these homeostatic cells.