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Indrek Koppel
Researcher at Weizmann Institute of Science
Publications - 19
Citations - 1091
Indrek Koppel is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Brain-derived neurotrophic factor & Neurotrophic factors. The author has an hindex of 12, co-authored 17 publications receiving 916 citations. Previous affiliations of Indrek Koppel include Tallinn University of Technology.
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LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia
Clyde Francks,Shinji Maegawa,Juha Lauren,Brett S. Abrahams,Antonio Velayos-Baeza,Sarah E. Medland,Sarah E. Medland,Stefano Colella,Matthias Groszer,E. Z. McAuley,Tara M. Caffrey,Tõnis Timmusk,Priit Pruunsild,Indrek Koppel,Penelope A. Lind,N. Matsumoto-Itaba,Jérôme Nicod,Lan Xiong,Ridha Joober,Wolfgang Enard,B. Krinsky,Eiji Nanba,Anthony J. Richardson,Brien P. Riley,Nicholas G. Martin,Stephen M. Strittmatter,H.-J. Möller,Dan Rujescu,D. St Clair,Pierandrea Muglia,J. L. Roos,Simon E. Fisher,Richard Wade-Martins,Guy A. Rouleau,John F. Stein,Maria Karayiorgou,Daniel H. Geschwind,Jiannis Ragoussis,K. S. Kendler,Matti S. Airaksinen,Mitsuo Oshimura,Lynn E. DeLisi,Anthony P. Monaco +42 more
TL;DR: It is shown that LRRTM1 is expressed during the development of specific forebrain structures, and thus could influence neuronal differentiation and connectivity, and the first putative genetic effect on variability in human brain asymmetry is found.
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Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene.
TL;DR: The results of this study have identified the cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene and demonstrated that CRE and PasRE elements in hBDNF promoter IX are required for the induction of this promoter by neuronal activity.
Journal ArticleDOI
Locally translated mTOR controls axonal local translation in nerve injury.
Marco Terenzio,Sandip Koley,Nitzan Samra,Ida Rishal,Q Zhao,Pabitra K. Sahoo,Anatoly Urisman,Letizia Marvaldi,Juan A. Oses-Prieto,Craig M. Forester,Cynthia Gomes,Ashley L. Kalinski,Agostina Di Pizio,Ella Doron-Mandel,Rotem Ben-Tov Perry,Indrek Koppel,Jeffery L. Twiss,Jeffery L. Twiss,Alma L. Burlingame,Mike Fainzilber +19 more
TL;DR: Results show that mTOR (mechanistic target of rapamycin) was activated and then up-regulated in injured axons, owing to local translation of mTOR messenger RNA (mRNA), and this mRNA was transported into axons by the cell size–regulating RNA-binding protein nucleolin.
Journal ArticleDOI
Differential regulation of Bdnf expression in cortical neurons by class-selective histone deacetylase inhibitors
Indrek Koppel,Tõnis Timmusk +1 more
TL;DR: These findings implicate class II HDACs in transcriptional regulation of Bdnf and indicate that class II selective HDAC inhibitors may have potential as therapeutics for nervous system disorders.
Journal ArticleDOI
Tissue-specific and neural activity-regulated expression of human BDNF gene in BAC transgenic mice
Indrek Koppel,Tamara Aid-Pavlidis,Kaur Jaanson,Mari Sepp,Priit Pruunsild,Kaia Palm,Tõnis Timmusk +6 more
TL;DR: This is the first study to show that human BDNF gene is regulated by neural activity, and genomic region covering 67 kb of humanBDNF gene, 84 kb of upstream and 17 kb of downstream sequences is sufficient to drive tissue-specific and kainic acid-induced expression of the reporter gene in transgenic mice.