T
Tara M. Caffrey
Researcher at University of Oxford
Publications - 14
Citations - 895
Tara M. Caffrey is an academic researcher from University of Oxford. The author has contributed to research in topics: Exon & Haplotype. The author has an hindex of 9, co-authored 12 publications receiving 742 citations. Previous affiliations of Tara M. Caffrey include University of British Columbia & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia
Clyde Francks,Shinji Maegawa,Juha Lauren,Brett S. Abrahams,Antonio Velayos-Baeza,Sarah E. Medland,Sarah E. Medland,Stefano Colella,Matthias Groszer,E. Z. McAuley,Tara M. Caffrey,Tõnis Timmusk,Priit Pruunsild,Indrek Koppel,Penelope A. Lind,N. Matsumoto-Itaba,Jérôme Nicod,Lan Xiong,Ridha Joober,Wolfgang Enard,B. Krinsky,Eiji Nanba,Anthony J. Richardson,Brien P. Riley,Nicholas G. Martin,Stephen M. Strittmatter,H.-J. Möller,Dan Rujescu,D. St Clair,Pierandrea Muglia,J. L. Roos,Simon E. Fisher,Richard Wade-Martins,Guy A. Rouleau,John F. Stein,Maria Karayiorgou,Daniel H. Geschwind,Jiannis Ragoussis,K. S. Kendler,Matti S. Airaksinen,Mitsuo Oshimura,Lynn E. DeLisi,Anthony P. Monaco +42 more
TL;DR: It is shown that LRRTM1 is expressed during the development of specific forebrain structures, and thus could influence neuronal differentiation and connectivity, and the first putative genetic effect on variability in human brain asymmetry is found.
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A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders
Devika Agarwal,Devika Agarwal,Cynthia Sandor,Viola Volpato,Tara M. Caffrey,Tara M. Caffrey,Jimena Monzón-Sandoval,Rory Bowden,Javier Alegre-Abarrategui,Javier Alegre-Abarrategui,Richard Wade-Martins,Caleb Webber,Caleb Webber +12 more
TL;DR: It is shown that the common genetic risk for Parkinson’s disease (PD) is associated with dopaminergic neuron (DaN)-specific gene expression, including mitochondrial functioning, protein folding and ubiquitination pathways.
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Haplotype-specific expression of exon 10 at the human MAPT locus
TL;DR: It is proposed that the hypothesis that H1 expresses more exon 10+ MAPT mRNA compared to the other haplotype, H2, leading to a greater susceptibility to neurodegeneration in H1 carriers is investigated and a potential mechanism between MAPT genetic variability and the pathogenesis of Neurodegenerative disease is suggested.
Journal ArticleDOI
Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus.
TL;DR: In both cell culture and post-mortem brain tissue, it is shown that the protective MAPT H2 haplotype significantly expresses two-fold more 2N (exons 2+3+) MAPT transcripts than the disease-associated H1 haplotype.
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Functional MAPT haplotypes: bridging the gap between genotype and neuropathology.
TL;DR: The role of MAPT in sporadic and familial neurodegenerative disease is reviewed, and work which, for the first time, proposes functional mechanisms to link MAPT haplotypes with the neuropathology seen in patients is discussed.