Ines Thiele

TL;DR: This work presents the first comprehensive assessment of the B-vitamin synthesis capabilities of the human gut microbiota, and proposes that in addition to diet, the gut microbiota is an important source of B- vitamins, and that changes in the Gut microbiota composition can severely affect the authors' dietary B-Vitamin requirements.

TL;DR: Recon3D is presented, a computational resource that includes three-dimensional metabolite and protein structure data and enables integrated analyses of metabolic functions in humans and is used to functionally characterize mutations associated with disease, and identify metabolic response signatures that are caused by exposure to certain drugs.

TL;DR: The narrow range of chemical analyses in current use by the medical community today will be replaced in the future by analyses that reveal a far more comprehensive metabolic signature, expected to describe global biochemical aberrations that reflect patterns of variance in states of wellness, more accurately describe specific diseases and their progression, and greatly aid in differential diagnosis.

TL;DR: All four levels of genome annotation are discussed, with specific emphasis on two-dimensional annotation methods, and the study of changes in genome sequences that occur during adaptive evolution is studied.

TL;DR: An open source implementation of flux variability analysis called fastFVA is presented, which makes large-scale flux variabilityAnalysis feasible and tractable allowing more complex biological questions regarding network flexibility and robustness to be addressed.