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Ingrid Leiner
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 40
Citations - 4155
Ingrid Leiner is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 28, co-authored 40 publications receiving 3562 citations. Previous affiliations of Ingrid Leiner include Kettering University.
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Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands
Chao Shi,Ting Jia,Simón Méndez-Ferrer,Tobias M. Hohl,Natalya V. Serbina,Lauren Lipuma,Ingrid Leiner,Ming O. Li,Paul S. Frenette,Paul S. Frenette,Eric G. Pamer +10 more
TL;DR: It is demonstrated that low concentrations of Toll-like receptor (TLR) ligands in the bloodstream drive CCR2-dependent emigration of monocytes from bone marrow and that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses.
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Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense
Melissa A. Kinnebrew,Charlie G. Buffie,Gretchen E. Diehl,Lauren A. Zenewicz,Ingrid Leiner,Tobias M. Hohl,Richard A. Flavell,Richard A. Flavell,Dan R. Littman,Dan R. Littman,Eric G. Pamer +10 more
TL;DR: CD103(+)CD11b(+) LPDCs, in addition to promoting long-term tolerance to ingested antigens, also rapidly produce IL-23 in response to detection of flagellin in the lamina propria.
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Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice
Carles Ubeda,Lauren Lipuma,Asia Gobourne,Agnes Viale,Ingrid Leiner,Michele Equinda,Raya Khanin,Eric G. Pamer +7 more
TL;DR: Differences between TLR-deficient mouse colonies occur from extended husbandry in isolation that are communicated to offspring by maternal transmission.
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Additive Roles for MCP-1 and MCP-3 in CCR2-Mediated Recruitment of Inflammatory Monocytes during Listeria monocytogenes Infection
Ting Jia,Natalya V. Serbina,Katharina Brandl,Maggie X. Zhong,Ingrid Leiner,Israel F. Charo,Eric G. Pamer,Eric G. Pamer +7 more
TL;DR: It is shown that L. monocytogenes infection rapidly induces MCP-3 in tissue culture macrophages and in serum, spleen, liver, and kidney following in vivo infection, suggesting that cytosolic innate immune detection mechanisms trigger chemokine production.
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Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium
Silvia Caballero,Sohn Kim,Rebecca A. Carter,Ingrid Leiner,Bože Sušac,Liza Miller,Grace Kim,Lilan Ling,Eric G. Pamer,Eric G. Pamer +9 more
TL;DR: These findings suggest that therapeutic or prophylactic administration of defined bacterial consortia to individuals with compromised microbiota composition may reduce inter-patient transmission and intra-patient dissemination of highly antibiotic-resistant pathogens.