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Ingrid Müller-Fleckenstein
Researcher at University of Erlangen-Nuremberg
Publications - 27
Citations - 2416
Ingrid Müller-Fleckenstein is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: T cell & Gammaherpesvirinae. The author has an hindex of 20, co-authored 27 publications receiving 2201 citations. Previous affiliations of Ingrid Müller-Fleckenstein include Harvard University.
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Journal ArticleDOI
Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a herpesvirus saimiri vector
Ralph Grassmann,Christine Dengler,Ingrid Müller-Fleckenstein,Bernhard Fleckenstein,Kathleen L. McGuire,Marie-Christine Dokhelar,Joseph Sodroski,William A. Haseltine +7 more
TL;DR: These experiments demonstrate that the X region encodes the functions of HTLV-I that immortalize a distinct subpopulation of human T cells and demonstrate the utility of the H. saimiri vector for the transduction of heterologous genes intohuman T cells.
Journal ArticleDOI
Revisiting Human IL-12Rβ1 Deficiency: A Survey of 141 Patients From 30 Countries
Ludovic de Beaucoudrey,Arina Samarina,Arina Samarina,Arina Samarina,Jacinta Bustamante,Jacinta Bustamante,Aurélie Cobat,Aurélie Cobat,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Jacqueline Feinberg,Saleh Al-Muhsen,Lucile Janniere,Yoann Rose,Maylis de Suremain,Xiao-Fei Kong,Orchidée Filipe-Santos,Ariane Chapgier,Capucine Picard,Alain Fischer,Figen Dogu,Aydan Ikinciogullari,Gonul Tanir,Sami Al-Hajjar,Suliman Al-Jumaah,Husn H. Frayha,Zobaida Alsum,Sulaiman Al-Ajaji,Abdullah A. Alangari,Abdulaziz Al-Ghonaium,Parisa Adimi,Davood Mansouri,Imen Ben-Mustapha,Judith Yancoski,Ben-Zion Garty,Carlos Rodríguez-Gallego,Isabel Caragol,Necil Kutukculer,Dinakantha S. Kumararatne,Smita Y. Patel,Rainer Doffinger,Andrew Exley,Olle Jeppsson,Janine Reichenbach,David Nadal,Yaryna Boyko,Barbara Pietrucha,Suzanne T. Anderson,Michael Levin,Liliane Schandené,Kinda Schepers,André Efira,Françoise Mascart,Masao Matsuoka,Tatsunori Sakai,Claire-Anne Siegrist,Klara Frecerova,Renate Blüetters-Sawatzki,Jutta Bernhöft,Joachim Freihorst,Ulrich Baumann,Darko Richter,Filomeen Haerynck,Frans De Baets,Vas Novelli,David A. Lammas,Christiane Vermylen,David Tuerlinckx,Chris Nieuwhof,Małgorzata Pac,Walther H. Haas,Ingrid Müller-Fleckenstein,Bernhard Fleckenstein,Jacob Levy,Revathi Raj,Aileen C. Cohen,David B. Lewis,Steven M. Holland,Kuender D Yang,Xiaochuan Wang,Xiaohong Wang,Li-Ping Jiang,Xi-qiang Yang,Chaomin Zhu,Yuanyuan Xie,Pamela Pui Wah Lee,Koon Wing Chan,Tong-Xin Chen,Gabriela Castro,Ivelisse Natera,Ana Codoceo,Alejandra King,Liliana Bezrodnik,Daniela Di Giovani,María Isabel Gaillard,Dewton Moraes-Vasconcelos,Anete Sevciovic Grumach,Alberto José da Silva Duarte,Ruth Aldana,Francisco J. Espinosa-Rosales,Mohammed Bejaoui,Ahmed Aziz Bousfiha,Jamila El Baghdadi,Namik Ozbek,Guzide Aksu,Melike Keser,Ayper Somer,Nevin Hatipoğlu,Cigdem Aydogmus,Suna Asilsoy,Yildiz Camcioglu,Saniye Gülle,Tuba Turul Ozgur,Meteran Ozen,Matías Oleastro,Andrea Bernasconi,Setareh Mamishi,Nima Parvaneh,Sergio D. Rosenzweig,Ridha Barbouche,Sigifredo Pedraza,Yu-Lung Lau,Mohammad S. Ehlayel,Claire Fieschi,Laurent Abel,Ozden Sanal,Jean-Laurent Casanova +127 more
TL;DR: An international survey of 141 patients from 102 kindreds in 30 countries found that IL-12R&bgr;1 deficiency has higher clinical penetrance, broader susceptibility to infections, and less favorable outcome than previously thought.
Journal ArticleDOI
Stable growth transformation of human T lymphocytes by herpesvirus saimiri.
Brigitte Biesinger,Ingrid Müller-Fleckenstein,Birgit Simmer,Gerlinde Lang,Sabine Wittmann,Erich Platzer,Ronald C. Desrosiers,Bernhard Fleckenstein +7 more
TL;DR: It is reported that infection of human blood lymphocytes and thymocytes with strains of subgroup C, in contrast to viruses of the other subgroups, yields continuously proliferating T-cell lines with the phenotype of mature CD4- or CD8-positive cells.
Journal ArticleDOI
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
Alexandra Y. Kreins,Alexandra Y. Kreins,Michael J. Ciancanelli,Satoshi Okada,Xiao-Fei Kong,Noé Ramírez-Alejo,Sara Sebnem Kilic,Jamila El Baghdadi,Shigeaki Nonoyama,Seyed Alireza Mahdaviani,Fatima Ailal,Aziz Bousfiha,Davood Mansouri,Elma Nievas,Cindy S. Ma,Cindy S. Ma,Geetha Rao,Andrea Bernasconi,Hye Sun Kuehn,Julie E. Niemela,Jennifer Stoddard,Paul Deveau,Paul Deveau,Aurélie Cobat,Aurélie Cobat,Safa El Azbaoui,Ayoub Sabri,Che Kang Lim,Che Kang Lim,Mikael Sundin,Danielle T. Avery,Rabih Halwani,Audrey V. Grant,Audrey V. Grant,Bertrand Boisson,Dusan Bogunovic,Yuval Itan,Marcela Moncada-Vélez,Marcela Moncada-Vélez,Rubén Martínez-Barricarte,Mélanie Migaud,Mélanie Migaud,Caroline Deswarte,Caroline Deswarte,Laia Alsina,Laia Alsina,Daniel Kotlarz,Christoph Klein,Ingrid Müller-Fleckenstein,Bernhard Fleckenstein,Valérie Cormier-Daire,Stefan Rose-John,Capucine Picard,Lennart Hammarström,Anne Puel,Anne Puel,Saleh Al-Muhsen,Laurent Abel,Laurent Abel,Laurent Abel,Damien Chaussabel,Sergio D. Rosenzweig,Yoshiyuki Minegishi,Stuart G. Tangye,Stuart G. Tangye,Jacinta Bustamante,Jacinta Bustamante,Jean-Laurent Casanova,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis +70 more
TL;DR: The identification and immunological characterization of a group of TYK2-deficient patients is reported and they are described as having at least some of the hallmarks of central giant cell apoptosis.
Journal ArticleDOI
Atypical X-Linked Severe Combined Immunodeficiency Due to Possible Spontaneous Reversion of the Genetic Defect in T Cells
Stephan,Wahn,Le Deist F,Dirksen U,Barbara M. Bröker,Ingrid Müller-Fleckenstein,Gerd Horneff,Schroten H,Alain Fischer,de Saint Basile G +9 more
TL;DR: X-linked severe combined immunodeficiency is a recessive hereditary disease characterized by severe and persistent infections starting in the first months of life and associated with diarrhea and failure to thrive.