I
Irving F. Hoffman
Researcher at University of North Carolina at Chapel Hill
Publications - 288
Citations - 20382
Irving F. Hoffman is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Population & Acquired immunodeficiency syndrome (AIDS). The author has an hindex of 52, co-authored 270 publications receiving 18634 citations. Previous affiliations of Irving F. Hoffman include Kamuzu Central Hospital & FHI 360.
Papers
More filters
Journal ArticleDOI
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more
TL;DR: In this article, Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples.
Journal ArticleDOI
Antiretroviral Therapy for the Prevention of HIV-1 Transmission
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Leslie Cottle,Xinyi C. Zhang,Joseph Makhema,Lisa A. Mills,Ravindre Panchia,Sharlaa Faesen,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Max Essex,Sarah E. Hudelson,Andrew D. Redd,Thomas R. Fleming +35 more
TL;DR: The early initiation of ART led to a sustained decrease in genetically linked HIV-1 infections in sexual partners, and was associated with a 93% lower risk of linked partner infection than was delayed ART.
Journal ArticleDOI
Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1
Myron S. Cohen,Irving F. Hoffman,Rachel A. Royce,Peter N. Kazembe,John R. Dyer,Celine Costello Daly,Dick Zimba,Pietro Vernazza,Martin Maida,Susan A. Fiscus,Joseph J. Eron +10 more
TL;DR: HIV-1-control programmes, which include detection and treatment of STDs in patients already infected with HIV-1, may help to curb the epidemic and targeting of gonococcal urethritis may be a particularly effective strategy.
Journal ArticleDOI
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children.
Selidji T Agnandji,Bertrand Lell,Bertrand Lell,Solange Soulanoudjingar,Solange Soulanoudjingar,José Francisco Fernandes,José Francisco Fernandes,Béatrice Peggy Abossolo,Béatrice Peggy Abossolo,Cornelia Conzelmann,Cornelia Conzelmann,Barbara Gaelle Nfono Ondo Methogo,Barbara Gaelle Nfono Ondo Methogo,Yannick Doucka,Yannick Doucka,Arnaud Flamen,Arnaud Flamen,Benjamin Mordmüller,Benjamin Mordmüller,Saadou Issifou,Saadou Issifou,Peter G. Kremsner,Peter G. Kremsner,Jahit Sacarlal,Pedro Aide,Miguel A. Lanaspa,John J. Aponte,Arlindo Nhamuave,Diana Quelhas,Quique Bassat,Sofia Mandjate,Eusebio Macete,Pedro L. Alonso,Salim Abdulla,Nahya Salim,Omar Juma,Mwanajaa Shomari,Kafuruki Shubis,Francisca Machera,Ali Hamad,Rose Minja,Ali Mtoro,Alma Sykes,Saumu Ahmed,Alwisa Urassa,Ali Ali,Grace Mwangoka,Marcel Tanner,Halidou Tinto,Umberto D'Alessandro,Hermann Sorgho,Innocent Valea,Marc Christian Tahita,William Kabore,Sayouba Ouedraogo,Yara Sandrine,Robert T. Guiguemdé,Jean-Bosco Ouédraogo,Mary J. Hamel,Simon Kariuki,Chris Odero,Martina Oneko,Kephas Otieno,Norbert Awino,Jackton Omoto,John Williamson,Vincent Muturi-Kioi,Kayla F. Laserson,Laurence Slutsker,Walter Otieno,Lucas Otieno,Otsyula Nekoye,Stacey M. O. Gondi,Allan Otieno,Bernhards Ogutu,Ruth Wasuna,Victorine Owira,David B. Jones,Agnes Akoth Onyango,Patricia Njuguna,Roma Chilengi,Pauline Akoo,Christine Kerubo,Jesse Gitaka,Charity Maingi,Trudie Lang,Ally Olotu,Benjamin Tsofa,Philip Bejon,Norbert Peshu,Kevin Marsh,Seth Owusu-Agyei,Kwaku Poku Asante,Kingsley Osei-Kwakye,Owusu Boahen,Samuel Ayamba,Kingsley Kayan,Ruth Owusu-Ofori,David Dosoo,Isaac Asante,George Adjei,Daniel Chandramohan,Brian Greenwood,John Lusingu,Samwel Gesase,Anangisye Malabeja,Omari Abdul,Hassan Kilavo,Coline Mahende,Edwin Liheluka,Martha M. Lemnge,Thor G. Theander,Chris Drakeley,Daniel Ansong,Tsiri Agbenyega,Samuel Adjei,Harry Owusu Boateng,Theresa Rettig,John Bawa,Justice Sylverken,David Sambian,Alex Agyekum,Larko Owusu,Francis Martinson,Irving F. Hoffman,Tisungane Mvalo,Portia Kamthunzi,Ruthendo Nkomo,Albans Msika,Allan Jumbe,Nelecy Chome,Dalitso Nyakuipa,Joseph Chintedza,W. Ripley Ballou,Myriam Bruls,Joe Cohen,Yolanda Guerra,Erik Jongert,Didier Lapierre,Amanda J. Leach,Marc Lievens,Opokua Ofori-Anyinam,Johan Vekemans,Terrell Carter,Didier Leboulleux,Christian Loucq,Afiya Radford,Barbara Savarese,David Schellenberg,Marla Sillman,Preeti Vansadia +150 more
TL;DR: The RTS,S/AS01 vaccine provided protection against both clinical and severe malaria in African children, and serious adverse events occurred with a similar frequency in the two study groups.
Journal ArticleDOI
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.
Selidji T Agnandji,Selidji T Agnandji,Bertrand Lell,Bertrand Lell,José Francisco Fernandes,José Francisco Fernandes,Béatrice Peggy Abossolo,Béatrice Peggy Abossolo,Barbara Gaelle Nfono Ondo Methogo,Barbara Gaelle Nfono Ondo Methogo,Anita Lumeka Kabwende,Anita Lumeka Kabwende,Ayola A. Adegnika,Ayola A. Adegnika,Benjamin Mordmüller,Benjamin Mordmüller,Saadou Issifou,Saadou Issifou,Peter G. Kremsner,Peter G. Kremsner,Jahit Sacarlal,Pedro Aide,Miguel Lanaspa,John J. Aponte,Sonia Machevo,Sozinho Acácio,Helder Bulo,Betuel Sigaúque,Eusebio Macete,Pedro L. Alonso,Salim Abdulla,Salim Abdulla,Nahya Salim,Nahya Salim,Rose Minja,Rose Minja,Maxmillian Mpina,Maxmillian Mpina,Saumu Ahmed,Saumu Ahmed,Ali Ali,Ali Ali,Ali Mtoro,Ali Mtoro,Ali Hamad,Ali Hamad,Paul Mutani,Paul Mutani,Marcel Tanner,Marcel Tanner,Halidou Tinto,Umberto D'Alessandro,Hermann Sorgho,Innocent Valea,Biebo Bihoun,Issa Guiraud,Berenger Kaboré,Olivier Sombié,Robert T. Guiguemdé,Jean-Bosco Ouédraogo,Mary J. Hamel,Simon Kariuki,Martina Oneko,Chris Odero,Kephas Otieno,Norbert Awino,Meredith McMorrow,Vincent Muturi-Kioi,Kayla F. Laserson,Laurence Slutsker,Walter Otieno,Lucas Otieno,Nekoye Otsyula,Stacey M. O. Gondi,Allan Otieno,Victorine Owira,Esther Oguk,George Odongo,Jon Ben Woods,Bernhards Ogutu,Patricia Njuguna,Roma Chilengi,Pauline Akoo,Christine Kerubo,Charity Maingi,Trudie Lang,Ally Olotu,Philip Bejon,Kevin Marsh,Gabriel Mwambingu,Seth Owusu-Agyei,Kwaku Poku Asante,Kingsley Osei-Kwakye,Owusu Boahen,David Dosoo,Isaac Asante,George Adjei,Evans Kwara,Daniel Chandramohan,Brian Greenwood,John Lusingu,John Lusingu,John Lusingu,Samwel Gesase,Samwel Gesase,Samwel Gesase,Anangisye Malabeja,Anangisye Malabeja,Anangisye Malabeja,Omari Abdul,Omari Abdul,Omari Abdul,Coline Mahende,Coline Mahende,Coline Mahende,Edwin Liheluka,Edwin Liheluka,Edwin Liheluka,Lincoln Malle,Lincoln Malle,Lincoln Malle,M.M. Lemnge,M.M. Lemnge,M.M. Lemnge,Thor G. Theander,Thor G. Theander,Thor G. Theander,Chris Drakeley,Chris Drakeley,Chris Drakeley,Daniel Ansong,Tsiri Agbenyega,Samuel Adjei,Harry Owusu Boateng,Theresa Rettig,John Bawa,Justice Sylverken,David Sambian,Anima Sarfo,Alex Agyekum,Francis Martinson,Irving F. Hoffman,Tisungane Mvalo,Portia Kamthunzi,Rutendo Nkomo,Tapiwa Tembo,Gerald Tegha,Mercy Tsidya,Jane Kilembe,Chimwemwe Chawinga,W. Ripley Ballou,Joe Cohen,Yolanda Guerra,Erik Jongert,Didier Lapierre,Amanda J. Leach,Marc Lievens,Opokua Ofori-Anyinam,Aurélie Olivier,Johan Vekemans,Terrell Carter,David C. Kaslow,Didier Leboulleux,Christian Loucq,Afiya Radford,Barbara Savarese,David Schellenberg,Marla Sillman,Preeti Vansadia +168 more
TL;DR: The RTS,S/AS01 vaccine coadministered with EPI vaccines provided modest protection against both clinical and severe malaria in young infants.