Isabela Pedroza-Pacheco

TL;DR: This work suggests that incipient signaling in T cells initiates global cytoskeletal rearrangements across the whole cell, including a stiffening process for possibly mechanically supporting contact formation at the immunological synapse interface as well as a central ramified transportation network apparently directed at the consolidation of the contact and the delivery of effector functions.

TL;DR: It is found that broadly neutralizing antibody production associates with particular immune traits, including a higher frequency of autoantibodies, fewer regulatory T cells, and more circulating memory T follicular helper cells, in HIV-1–infected individuals.

TL;DR: The data suggest that NK cells and Rab11 recycling endosomal transport are involved in regulation of HIV-1 bnAb development, and that RAB11FIP5 overexpression modulated the function of NK cells.

TL;DR: Analysis of antibody heavy-chain repertoires in a large cohort of HIV-infected individuals found consistent features of bNAb repertoires, encompassing thousands of B cell clones per individual, with correlated T cell phenotypes, indicate that the development of numerous B cell lineages with antibody features associated with autoreactivity may be a key aspect in theDevelopment of HIV neutralizing antibody breadth.

TL;DR: In five cases of asymptomatic Epstein-Barr virus infection, viral loads in the blood were as high as those in patients during the acute phase of IM, whereas the cell-mediated responses, even when they resembled those in Patients during the intensive care unit of IM in timing and quality, were never as exaggerated.