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István Tornai
Researcher at University of Debrecen
Publications - 103
Citations - 1634
István Tornai is an academic researcher from University of Debrecen. The author has contributed to research in topics: Viral hepatitis & Cirrhosis. The author has an hindex of 18, co-authored 101 publications receiving 1270 citations. Previous affiliations of István Tornai include Katholieke Universiteit Leuven.
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Journal ArticleDOI
The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology.
Jonel Trebicka,Javier J.M. Fernández,Mária Papp,Paolo Caraceni,Wim Laleman,Carmine Gambino,Ilaria Giovo,Frank Erhard Uschner,Cesar Jimenez,Rajeshwar P. Mookerjee,Thierry Gustot,Agustín Albillos,Rafael Bañares,Martin Janicko,Christian J. Steib,Thomas Reiberger,Juan Acevedo,Pietro Gatti,William Bernal,Stefan Zeuzem,Alexander Zipprich,Salvatore Piano,Thomas Berg,Tony Bruns,Flemming Bendtsen,Minneke J. Coenraad,Manuela Merli,Rudolf E. Stauber,Heinz Zoller,Jose Presa Ramos,Cristina Solé,Germán Soriano,Andrea De Gottardi,Henning Grønbæk,Faouzi Saliba,Christian Trautwein,Osman Ozdogan,Sven Francque,Stephen D. Ryder,Pierre Nahon,Manuel Romero-Gómez,Hans Van Vlierberghe,Claire Francoz,Michael Manns,Elisabet Garcia,Manuel Tufoni,Alex Amoros,Marco Pavesi,Cristina Sanchez,Anna Curto,Carla Pitarch,Antonella Putignano,Esau Moreno,Debbie L. Shawcross,Ferran Aguilar,Joan Clària,Paola Ponzo,Christian Jansen,Zsuzsanna Vitális,Giacomo Zaccherini,Boglarka Balogh,Victor Vargas,Sara Montagnese,Carlo Alessandria,Mauro Bernardi,Pere Ginès,Rajiv Jalan,Richard Moreau,Paolo Angeli,Vicente Arroyo,Miriam Maschmeier,David Semela,Laure Elkrief,Ahmed Elsharkawy,Tamas Tornai,István Tornai,István Altorjay,Agnese Antognoli,Maurizio Baldassarre,Martina Gagliardi,Eleonora Bertoli,Sara Mareso,Alessandra Brocca,Daniela Campion,Giorgio Maria Saracco,Martina Rizzo,Jennifer Lehmann,Alessandra Pohlmann,Michael Praktiknjo,Robert Schierwagen,Robert Schierwagen,Elsa Solà,Nesrine Amari,Miguel Á. Rodríguez,Frederik Nevens,Ana Clemente,Peter Jarcuska,Alexander L. Gerbes,Mattias Mandorfer,Christoph Welsch,Emanuela Ciraci,Vish Patel,Cristina Ripoll,Adam Herber,Paul Horn,Karen Vagner Danielsen,Lise Lotte Gluud,Jelte J Schaapman,Oliviero Riggio,Florian Rainer,Jörg Tobiasch Moritz,Monica Mesquita,Edilmar Alvarado-Tapias,Osagie Akpata,Peter Lykke Eriksen,Didier Samuel,Sylvie Tresson,Pavel Strnad,Roland Amathieu,Macarena Simón-Talero,Francois Smits,Natalie Van den Ende,Javier Martínez,Rita Garcia,Daniel Markwardt,Harald Rupprechter,Cornelius Engelmann +126 more
TL;DR: Acute decompensation without ACLF is a heterogeneous condition with three different clinical courses and two major pathophysiological mechanisms: systemic inflammation and portal hypertension.
Journal ArticleDOI
norUrsodeoxycholic acid improves cholestasis in primary sclerosing cholangitis
Peter Fickert,Gideon M. Hirschfield,Gerald Denk,Hanns-Ulrich Marschall,István Altorjay,Martti Färkkilä,Christoph Schramm,Ulrich Spengler,Roger W. Chapman,Annika Bergquist,Erik Schrumpf,Frederik Nevens,Palak J. Trivedi,Florian P. Reiter,István Tornai,Emina Halilbasic,Roland Greinwald,Markus Pröls,Michael P. Manns,Michael Trauner +19 more
TL;DR: A side chain-shortened derivative of ursodeoxycholic acid, norursodexycholic Acid (norUDCA), significantly reduced serum alkaline phosphatase levels in a dose-dependent manner during a 12-week treatment and showed a favorable safety profile, which was similar to placebo.
Journal ArticleDOI
PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
Jonel Trebicka,Javier Romaní Fernández,Mária Papp,Paolo Caraceni,Wim Laleman,Carmine Gambino,Ilaria Giovo,Frank Erhard Uschner,Christian Jansen,Cesar Jimenez,Rajeshwar P. Mookerjee,Thierry Gustot,Agustín Albillos,Rafael Bañares,Peter Jarcuska,Christian J. Steib,Thomas Reiberger,Juan Acevedo,Pietro Gatti,Debbie L. Shawcross,Stefan Zeuzem,Alexander Zipprich,Salvatore Piano,Thomas Berg,Tony Bruns,Karen Vagner Danielsen,Minneke J. Coenraad,Manuela Merli,Rudolf E. Stauber,Heinz Zoller,Jose Presa Ramos,Cristina Solé,Germán Soriano,Andrea De Gottardi,Henning Grønbæk,Faouzi Saliba,Christian Trautwein,Haluk Tarik Kani,Sven Francque,Stephen D. Ryder,Pierre Nahon,Pierre Nahon,Manuel Romero-Gómez,Hans Van Vlierberghe,Claire Francoz,Michael Manns,Elisabet Garcia-Lopez,Manuel Tufoni,Alex Amoros,Marco Pavesi,Cristina Sanchez,Michael Praktiknjo,Anna Curto,Carla Pitarch,Antonella Putignano,Esau Moreno,William Bernal,Ferran Aguilar,Joan Clària,Paola Ponzo,Zsuzsanna Vitális,Giacomo Zaccherini,Boglarka Balogh,Alexander L. Gerbes,Victor Vargas,Carlo Alessandria,Mauro Bernardi,Pere Ginès,Richard Moreau,Paolo Angeli,Rajiv Jalan,Vicente Arroyo,Miriam Maschmeier,David Semela,Laure Elkrief,Ahmed Elsharkawy,Tamas Tornai,István Tornai,István Altorjay,Agnese Antognoli,Maurizio Baldassarre,Martina Gagliardi,Eleonora Bertoli,Sara Mareso,Alessandra Brocca,Daniela Campion,Giorgio Maria Saracco,Martina Rizzo,Jennifer Lehmann,Alessandra Pohlmann,Maximilian J. Brol,Johannes Chang,Robert Schierwagen,Elsa Solà,Nesrine Amari,Miguel Á. Rodríguez,Frederik Nevens,Ana Clemente,Martin Janicko,Daniel Markwardt,Mattias Mandorfer,Christoph Welsch,T.M. Welzel,Emanuela Ciraci,Vish Patel,Cristina Ripoll,Adam Herber,Paul Horn,Flemming Bendtsen,Lise Lotte Gluud,Jelte J Schaapman,Oliviero Riggio,Florian Rainer,Joerg Tobiasch Moritz,Monica Mesquita,Edilmar Alvarado-Tapias,Osagie Akpata,Luise Aamann,Didier Samuel,Sylvie Tresson,Pavel Strnad,Roland Amathieu,Roland Amathieu,Macarena Simón-Talero,Francois Smits,Natalie Van den Ende,Javier Martínez,Rita Garcia,Harald Rupprechter,Cornelius Engelmann,Osman Ozdogan +130 more
TL;DR: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD and specific preventive and therapeutic strategies targeting these events may improve outcome in decompensated cirrhosis.
Journal ArticleDOI
High serum osteoprotegerin and low RANKL in primary biliary cirrhosis
Ferenc Szalay,Dalma Hegedus,Peter L. Lakatos,István Tornai,E Bajnok,Kinga Dunkel,Péter Lakatos +6 more
TL;DR: The mechanisms and role of elevated osteoprotegerin and low RANKL in PBC are unclear, but it might partly represent a compensatory mechanism to negative balance of bone remodeling.
Journal ArticleDOI
Acute phase proteins in the diagnosis and prediction of cirrhosis associated bacterial infections
Mária Papp,Zsuzsanna Vitális,István Altorjay,István Tornai,Miklós Udvardy,Jolan Harsfalvi,András Vida,János Kappelmayer,Peter L. Lakatos,Péter Antal-Szalmás +9 more
TL;DR: Bacterial infections are common cause of morbidity and mortality in patients with cirrhosis and the early diagnosis of these infections is rather difficult.