PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
Jonel Trebicka,Javier Romaní Fernández,Mária Papp,Paolo Caraceni,Wim Laleman,Carmine Gambino,Ilaria Giovo,Frank Erhard Uschner,Christian Jansen,Cesar Jimenez,Rajeshwar P. Mookerjee,Thierry Gustot,Agustín Albillos,Rafael Bañares,Peter Jarcuska,Christian J. Steib,Thomas Reiberger,Juan Acevedo,Pietro Gatti,Debbie L. Shawcross,Stefan Zeuzem,Alexander Zipprich,Salvatore Piano,Thomas Berg,Tony Bruns,Karen Vagner Danielsen,Minneke J. Coenraad,Manuela Merli,Rudolf E. Stauber,Heinz Zoller,Jose Presa Ramos,Cristina Solé,Germán Soriano,Andrea De Gottardi,Henning Grønbæk,Faouzi Saliba,Christian Trautwein,Haluk Tarik Kani,Sven Francque,Stephen D. Ryder,Pierre Nahon,Pierre Nahon,Manuel Romero-Gómez,Hans Van Vlierberghe,Claire Francoz,Michael Manns,Elisabet Garcia-Lopez,Manuel Tufoni,Alex Amoros,Marco Pavesi,Cristina Sanchez,Michael Praktiknjo,Anna Curto,Carla Pitarch,Antonella Putignano,Esau Moreno,William Bernal,Ferran Aguilar,Joan Clària,Paola Ponzo,Zsuzsanna Vitális,Giacomo Zaccherini,Boglarka Balogh,Alexander L. Gerbes,Victor Vargas,Carlo Alessandria,Mauro Bernardi,Pere Ginès,Richard Moreau,Paolo Angeli,Rajiv Jalan,Vicente Arroyo,Miriam Maschmeier,David Semela,Laure Elkrief,Ahmed Elsharkawy,Tamas Tornai,István Tornai,István Altorjay,Agnese Antognoli,Maurizio Baldassarre,Martina Gagliardi,Eleonora Bertoli,Sara Mareso,Alessandra Brocca,Daniela Campion,Giorgio Maria Saracco,Martina Rizzo,Jennifer Lehmann,Alessandra Pohlmann,Maximilian J. Brol,Johannes Chang,Robert Schierwagen,Elsa Solà,Nesrine Amari,Miguel Á. Rodríguez,Frederik Nevens,Ana Clemente,Martin Janicko,Daniel Markwardt,Mattias Mandorfer,Christoph Welsch,T.M. Welzel,Emanuela Ciraci,Vish Patel,Cristina Ripoll,Adam Herber,Paul Horn,Flemming Bendtsen,Lise Lotte Gluud,Jelte J Schaapman,Oliviero Riggio,Florian Rainer,Joerg Tobiasch Moritz,Monica Mesquita,Edilmar Alvarado-Tapias,Osagie Akpata,Luise Aamann,Didier Samuel,Sylvie Tresson,Pavel Strnad,Roland Amathieu,Roland Amathieu,Macarena Simón-Talero,Francois Smits,Natalie Van den Ende,Javier Martínez,Rita Garcia,Harald Rupprechter,Cornelius Engelmann,Osman Ozdogan +130 more
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TLDR
This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD and specific preventive and therapeutic strategies targeting these events may improve outcome in decompensated cirrhosis.About:
This article is published in Journal of Hepatology.The article was published on 2021-05-01 and is currently open access. It has received 125 citations till now. The article focuses on the topics: Alcoholic hepatitis & Chronic liver disease.read more
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Supplement to: Time to treatment and mortality during mandated emergency care for sepsis.
TL;DR: More rapid completion of a 3‐hour bundle of sepsis care and rapid administration of antibiotics, but not rapid completed of an initial bolus of intravenous fluids, were associated with lower risk‐adjusted in‐hospital mortality.
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The Systemic Inflammation Hypothesis: Towards a New Paradigm of Acute Decompensation and Multiorgan Failure in Cirrhosis
Vicente Arroyo,Paolo Angeli,Richard Moreau,Rajiv Jalan,Joan Clària,Jonel Trebicka,Javier Fernández,Thierry Gustot,Paolo Caraceni,Mauro Bernardi +9 more
TL;DR: This work presents a working hypothesis, the Systemic Inflammation Hypothesis, suggesting that systemic inflammation through an impairment of the functions of one or more of the major organ systems may be a common theme and act synergistically with the traditional mechanisms involved in the development of AD.
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EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients.
TL;DR: In this paper, a review summarises the data on vaccine safety, immunogenicity, and efficacy in this patient population in general and discusses the implications of this knowledge on the introduction of the new SARS-CoV-2 vaccines.
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Acute-on-Chronic Liver Failure Clinical Guidelines
Jasmohan S. Bajaj,Jacqueline G. O'Leary,Jennifer C. Lai,Florence Wong,Millie D. Long,Robert J. Wong,Patrick S. Kamath +6 more
TL;DR: These guidelines indicate the preferred approach to the management of patients with acute-on-chronic liver failure and represent the official practice recommendations of the American College of Gastroenterology.
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Hypoalbuminemia as Surrogate and Culprit of Infections.
TL;DR: In this paper, a causal link between hypoalbuminemia and increased risks of primary and secondary infections was found. But, the evidence of the beneficial effects of HAS on infections in hypo-albuminemic patients without cirrhosis is largely observational.
References
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A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk
TL;DR: In this paper, a class of tests developed for comparing the cumulative incidence of a particular type of failure among different groups is presented. The tests are based on comparing weighted averages of the hazards of the subdistribution for the failure type of interest.
Journal ArticleDOI
Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis
Richard Moreau,Rajiv Jalan,Pere Ginès,Marco Pavesi,Paolo Angeli,Juan Córdoba,François Durand,Thierry Gustot,Faouzi Saliba,Marco Domenicali,Alexander L. Gerbes,Julia Wendon,Carlo Alessandria,Wim Laleman,Stefan Zeuzem,Jonel Trebicka,Mauro Bernardi,Vicente Arroyo +17 more
TL;DR: Diagnostic criteria for ACLF was established and showed that it is distinct from AD, based not only on the presence of organ failure(s) and high mortality rate but also on age, precipitating events, and systemic inflammation.
Journal ArticleDOI
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
Paolo Angeli,Mauro Bernardi,Càndid Villanueva,Claire Francoz,Rajeshwar P. Mookerjee,Jonel Trebicka,Aleksander Krag,Wim Laleman,Pere Ginès +8 more
TL;DR: The panel of experts, having emphasised the importance of initiating aetiologic treatment for any degree of hepatic disease at the earliest possible stage, extended its work to all the complications of cirrhosis which had not been covered by the European Association for the Study of the Liver guidelines.
Journal ArticleDOI
Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis
Pau Sort,Miquel Navasa,Vicente Arroyo,Xavier Aldeguer,Ramon Planas,Luis Ruiz-del-Arbol,Lluis Castells,Victor Vargas,Germán Soriano,Mónica Guevara,Pere Ginès,Joan Rodés +11 more
TL;DR: In patients with cirrhosis and spontaneous bacterial peritonitis, treatment with intravenous albumin in addition to an antibiotic reduces the incidence of renal impairment and death in comparison with treatment with an antibiotic alone.
Journal ArticleDOI
Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure
Rajiv Jalan,Faouzi Saliba,Marco Pavesi,Alex Amoros,Richard Moreau,Pere Ginès,Eric Levesque,François Durand,Paolo Angeli,Paolo Caraceni,Corinna Hopf,Carlo Alessandria,Ezequiel Rodríguez,Pablo Solís-Muñoz,Wim Laleman,Jonel Trebicka,Stefan Zeuzem,Thierry Gustot,Rajeshwar P. Mookerjee,L. Elkrief,Germán Soriano,J. Córdoba,Filippo Morando,Alexander L. Gerbes,Banwari Agarwal,Didier Samuel,Mauro Bernardi,Vicente Arroyo +27 more
TL;DR: The CLIF-C ACLFs is a clinically relevant, validated scoring system that can be used sequentially to stratify the risk of mortality in ACLF patients and is superior to the MELDs and MELD-Nas in predicting mortality.
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