Anand Dixit

TL;DR: Patients with ischaemic stroke 4·5-9 h from stroke onset or wake-up stroke with salvageable brain tissue who were treated with alteplase achieved better functional outcomes than did patients given placebo, and this increase in the rate of symptomatic intracerebral haemorrhage did not negate the overall net benefit of thrombolysis.

TL;DR: The Pragmatic Ischaemic Thrombectomy Evaluation (PISTE) trial as discussed by the authors was a multicentre, randomised, controlled clinical trial comparing intravenous thrombolysis (IVT) alone with IVT and adjunctive intra-arterial mechanical thrombectoration (MT) in patients who had acute ischaemic stroke with large artery occlusive anterior circulation stroke confirmed on CT angiography (CTA).

TL;DR: Estimated ischaemic core volume was independently associated with functional independence and functional improvement but did not modify the treatment benefit of endovascular thrombectomy over standard medical therapy for improved functional outcome.

TL;DR: Better outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons.

TL;DR: This study suggests that VNS paired with rehabilitation is feasible and has not raised safety concerns, and additional studies of VNS in adults with chronic stroke will now be performed.