J
James T. Rutka
Researcher at University of Toronto
Publications - 642
Citations - 34051
James T. Rutka is an academic researcher from University of Toronto. The author has contributed to research in topics: Epilepsy & Epilepsy surgery. The author has an hindex of 84, co-authored 618 publications receiving 30391 citations. Previous affiliations of James T. Rutka include Princeton University & Toronto Western Hospital.
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Journal ArticleDOI
Molecular probes in neuro-oncology: a review.
Book ChapterDOI
Rho GTPases and Their Activators, Guanine Nucleotide Exchange Factors (GEFs): Their Roles in Glioma Cell Invasion
Bo Hu,Marc Symons,Bodour Salhia,Shannon P. Fortin,Nhan L. Tran,James T. Rutka,Shi Yuan Cheng +6 more
TL;DR: The role of Rho GTPases, particularly Rac1 and several GEFs including Trio, SWAP-70, Ect2, Vav3 and Dock180-ELMO1 in glioblastoma cell invasion is reviewed to help develop new therapeutic approaches to treat patients with malignant gliomas.
Posted ContentDOI
CASCADES, a novel SOX2 super-enhancer associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma multiforme
Uswa Shahzad,Christopher I. Li,Michael J. Johnston,Jenny Wang,Nesrin Sabha,Frederick S. Varn,Alexandra N. Riemenschneider,Stacey Krumholtz,Pranathi Meda,Christian A. Smith,Jason Karamchandani,Jonathan K. Watts,Roel G.W. Verhaak,Marco Gallo,James T. Rutka,Sunit Das,Sunit Das +16 more
TL;DR: Bioinformatics analysis reveals that CASCADES functions as a super-enhancer associated lncRNA epigenetic regulator of SOX2 and represents a novel epigenetic and therapeutic target for disrupting the cancer stem cell compartment in GBM.
Journal ArticleDOI
Risk factors for surgical site infection after intracranial electroencephalography monitoring for epilepsy in the pediatric population.
Ying Meng,Mathew Voisin,Suganth Suppiah,Zamir Merali,Ali Moghaddamjou,Naif M. Alotaibi,Arbelle Manicat-Emo,Shelly K. Weiss,Cristina Go,Bláthnaid McCoy,Elizabeth J. Donner,James T. Rutka +11 more
TL;DR: This is the largest case series and the first comprehensive review of both patient and operative risk factors in the development of SSI from iEEG monitoring in a pediatric population.
Journal ArticleDOI
Discovering neurosurgery: new frontiers.
TL;DR: In this address, some of the key discoveries in science and medicine that have impacted significantly on the field of neurosurgery are described, including discoveries in neuroanatomy, anesthesiology, infectious diseases, antisepsis, and radiology.