J
James T. Rutka
Researcher at University of Toronto
Publications - 642
Citations - 34051
James T. Rutka is an academic researcher from University of Toronto. The author has contributed to research in topics: Epilepsy & Epilepsy surgery. The author has an hindex of 84, co-authored 618 publications receiving 30391 citations. Previous affiliations of James T. Rutka include Princeton University & Toronto Western Hospital.
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Journal ArticleDOI
Expression of p57KIP2 Potently Blocks the Growth of Human Astrocytomas and Induces Cell Senescence
Atsushi Tsugu,Keiichi Sakai,Peter B. Dirks,Shin Jung,Rosanna Weksberg,Yan-Ling Fei,Soma Mondal,Stacey Ivanchuk,Cameron Ackerley,Paul A. Hamel,James T. Rutka +10 more
TL;DR: It is demonstrated that the proliferative block imposed by p57 on human astrocytoma cells results in changes in the expression of a number of cell cycle regulatory factors, cell morphology, and a strong stimulus to cell senescence.
Journal ArticleDOI
Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy.
Elysa Widjaja,Bing Li,Corrine Davies Schinkel,Lisa M. Puchalski Ritchie,Lisa M. Puchalski Ritchie,James Weaver,O. Carter Snead,James T. Rutka,Peter C. Coyte +8 more
TL;DR: Surgical treatment resulted in greater reduction in seizure frequency compared to medical therapy and was a cost-effective treatment option in children with intractable epilepsy who were evaluated for epilepsy surgery and subsequently underwent surgery compared to continuing medical therapy.
Journal ArticleDOI
Predictors of Seizure Outcomes in Children with Tuberous Sclerosis Complex and Intractable Epilepsy Undergoing Resective Epilepsy Surgery: An Individual Participant Data Meta-Analysis
Aria Fallah,Aria Fallah,Gordon H. Guyatt,O. Carter Snead,Shanil Ebrahim,George M. Ibrahim,Alireza Mansouri,Deven Reddy,Stephen D. Walter,Abhaya V. Kulkarni,Mohit Bhandari,Laura Banfield,Neera Bhatnagar,Shuli Liang,Federica Teutonico,Jianxiang Liao,James T. Rutka +16 more
TL;DR: The best available evidence suggests four preoperative factors predictive of good seizure outcomes following resective epilepsy surgery are suggested, some of which are overcome using individual participant data.
Journal ArticleDOI
Surgical decompression for symptomatic Chiari II malformation in neonates with myelomeningocele.
William P. Vandertop,Akio Asai,Harold J. Hoffman,James M. Drake,Robin P. Humphreys,James T. Rutka,Laurence E. Becker +6 more
TL;DR: The concept that compressive forces, rather than a primary intrinsic disorder of the brain-stem nuclei, play a crucial etiological role in the development of a symptomatic Chiari II malformation is supported.
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Dynamic modulation of epileptic high frequency oscillations by the phase of slower cortical rhythms.
George M. Ibrahim,Simeon M. Wong,Ryan Anderson,Gabrielle Singh-Cadieux,Tomoyuki Akiyama,Ayako Ochi,Hiroshi Otsubo,Tohru Okanishi,Taufik A. Valiante,Elizabeth J. Donner,James T. Rutka,O. Carter Snead,O. Carter Snead,Sam M. Doesburg +13 more
TL;DR: The results suggest that increased CFC between pHFO amplitude and alpha phase may constitute a marker of epileptogenic brain areas and may be relevant for understanding seizure dynamics.