J
James T. Rutka
Researcher at University of Toronto
Publications - 642
Citations - 34051
James T. Rutka is an academic researcher from University of Toronto. The author has contributed to research in topics: Epilepsy & Epilepsy surgery. The author has an hindex of 84, co-authored 618 publications receiving 30391 citations. Previous affiliations of James T. Rutka include Princeton University & Toronto Western Hospital.
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Journal ArticleDOI
Feasibility of radiosurgery for malignant brain tumors in infants by use of image-guided robotic radiosurgery: preliminary report.
Cole A. Giller,Brian D. Berger,Joseph P. Gilio,Janice L. Delp,Kenneth P. Gall,Bradley E. Weprin,Daniel C. Bowers,Steven D. Chang,Paul H. Chapman,Cheng Yu,James T. Rutka +10 more
TL;DR: Radiosurgery with minimal toxicity can be delivered to infants by use of a robotically controlled system that does not require rigid fixation, according to a formal dose-escalation trial under way.
Journal ArticleDOI
Stimulation threshold potentials of intraoperative cortical motor mapping using monopolar trains of five in pediatric epilepsy surgery
TL;DR: Monopolar electrical stimulation threshold for intraoperative motor cortical mapping were more consistent in the upper limb compared to lower limb and facial muscles and there was a distinct trend that patients with cortical dysplasia/tuberous sclerosis have higher stimulation thresholds.
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Inhibition of the MET Receptor Tyrosine Kinase as a Novel Therapeutic Strategy in Medulloblastoma.
TL;DR: The in vitro efficacy of targeting the MET receptor using the highly specific small molecule inhibitor PHA665752 as a novel treatment strategy in medulloblastoma is examined and support for further preclinical testing of small molecule inhibitors targeting theMET receptor in medULLoblastomas is provided.
Journal ArticleDOI
Characteristics of dipoles in clustered individual spikes and averaged spikes
Shiro Chitoku,Hiroshi Otsubo,Takashi Ichimura,Tatsuya Saigusa,Ayako Ochi,Atsushi Shirasawa,Kenichi Kamijo,Toshimasa Yamazaki,Elizabeth W. Pang,James T. Rutka,Shelly K. Weiss,O. Carter Snead +11 more
TL;DR: Characteristics of clustered interictal spikes need careful examination before the use of dipole analysis of averaged spikes for epilepsy evaluation, and more spike groups after clustering and fewer acceptable dipoles from averaged spikes in IETLE reflect variable spike activity over extensive epileptic regions.
Journal ArticleDOI
Clinical impact of combined epigenetic and molecular analysis of pediatric low-grade gliomas.
Kohei Fukuoka,Yasin Mamatjan,Ruth G. Tatevossian,Michal Zapotocky,Scott Ryall,Ana Guerreiro Stucklin,Julie Bennett,Liana Nobre,Anthony Arnoldo,Betty Luu,Ji Wen,Kaicen Zhu,Alberto Leon,Dax Torti,Trevor J. Pugh,Trevor J. Pugh,Trevor J. Pugh,Lili-Naz Hazrati,Normand Laperriere,James M. Drake,James T. Rutka,Peter B. Dirks,Abhaya V. Kulkarni,Michael D. Taylor,Ute Bartels,Annie Huang,Gelareh Zadeh,Kenneth Aldape,Vijay Ramaswamy,Eric Bouffet,Matija Snuderl,David W. Ellison,Cynthia Hawkins,Uri Tabori +33 more
TL;DR: The PLGG methylome is affected by multiple non-neoplastic factors and combined molecular and pathological analysis is key to provide additional information when methylation classification is used for PLGG in the clinical setting.