J
James T. Rutka
Researcher at University of Toronto
Publications - 642
Citations - 34051
James T. Rutka is an academic researcher from University of Toronto. The author has contributed to research in topics: Epilepsy & Epilepsy surgery. The author has an hindex of 84, co-authored 618 publications receiving 30391 citations. Previous affiliations of James T. Rutka include Princeton University & Toronto Western Hospital.
Papers
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Journal ArticleDOI
Diffuse Intrinsic Pontine Glioma : Clinical Features, Molecular Genetics, and Novel Targeted Therapeutics.
Ryan K. Mathew,James T. Rutka +1 more
TL;DR: A clinical overview of DIPG is provided, the barriers to progress in developing effective treatment, updates on drug development and preclinical models, and an introduction to new technologies aimed at enhancing drug delivery are provided.
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Transcriptional profiling of medulloblastoma in children.
Paul C. Park,Michael D. Taylor,Todd G. Mainprize,Laurence E. Becker,Michael Ho,Wieslaw T. Dura,Jeremy A. Squire,James T. Rutka +7 more
TL;DR: In this article, the expression patterns of gene expression in medulloblastoma samples with those in the healthy cerebellum were compared using complementary DNA microarray analysis and immunohistochemical analysis.
Journal ArticleDOI
ECT2 and RASAL2 Mediate Mesenchymal-Amoeboid Transition In Human Astrocytoma Cells
Adrienne Weeks,Nadia Okolowsky,Brian Golbourn,Stacey Ivanchuk,Christian A. Smith,James T. Rutka +5 more
TL;DR: It is revealed that ECT2 has a novel role in mesenchymal-amoeboid transition in human astrocytoma cells and is capable of activating these pro-migratory Rho family members.
Journal ArticleDOI
Massive plexiform neurofibromas in childhood: natural history and management issues
Demitre Serletis,Patricia C. Parkin,Eric Bouffet,Manohar Shroff,James M. Drake,James T. Rutka +5 more
TL;DR: The authors' experience suggests that resection should be considered in selected cases involving significant deterioration or functional compromise, and patients with massive PNs will benefit from close surveillance by a team of specialists to monitor for ongoing disease progression.
Journal ArticleDOI
Neocortical pathological high-frequency oscillations are associated with frequency-dependent alterations in functional network topology
George M. Ibrahim,Ryan Anderson,Tomoyuki Akiyama,Ayako Ochi,Hiroshi Otsubo,Gabrielle Singh-Cadieux,Elizabeth J. Donner,James T. Rutka,O. Carter Snead,O. Carter Snead,Sam M. Doesburg,Sam M. Doesburg +11 more
TL;DR: The view that abnormal network synchronization plays a critical role in ictogenesis and seizure dynamics is supported by the observation that functional isolation of epileptogenic cortex at high frequencies is absent at seizure termination.