J
James T. Rutka
Researcher at University of Toronto
Publications - 642
Citations - 34051
James T. Rutka is an academic researcher from University of Toronto. The author has contributed to research in topics: Epilepsy & Epilepsy surgery. The author has an hindex of 84, co-authored 618 publications receiving 30391 citations. Previous affiliations of James T. Rutka include Princeton University & Toronto Western Hospital.
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Multiple subpial transections in the treatment of pediatric epilepsy
Jeffrey P. Blount,Wayne Langburt,Hiroshi Otsubo,Shiro Chitoku,Ayako Ochi,Shelly K. Weiss,O. Carter Snead,James T. Rutka +7 more
TL;DR: The results of this series demonstrate that MSTs can be performed with acceptable morbidity in children undergoing epilepsy surgery, especially when combined with planned cortical resections.
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Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neuroepithelial tumor.
Ryoichi Sakuta,Hiroshi Otsubo,Melinda A. Nolan,Shelly K. Weiss,Cynthia Hawkins,James T. Rutka,Nathaniel A. Chuang,Sylvester H. Chuang,O. Carter Snead +8 more
TL;DR: Children with dysembryoplastic neuroepithelial tumor and cortical dysplasia often had recurrent intractable seizures postoperatively and required further epilepsy surgery and compared histopathology with seizure outcomes.
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Benign cerebellar astrocytoma in childhood: experience at the Hospital for Sick Children 1980-1992.
Mehdi Abdollahzadeh,Harold J. Hoffman,Susan I. Blazer,Laurence E. Becker,Robin P. Humphreys,James M. Drake,James T. Rutka +6 more
TL;DR: Total removal was possible in 61 patients and no recurrence occurred in these 61 patients, and in the 5 patients in whom an incomplete resection was carried out, regrowth occurred between 1 and 8 years following resection.
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ATM regulates 3-Methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents
Sameer Agnihotri,Kelly Burrell,Pawel Buczkowicz,Marc Remke,Brian Golbourn,Yevgen Chornenkyy,Aaron Gajadhar,Nestor A. Fernandez,Ian D. Clarke,Mark Barszczyk,Sanja Pajovic,Christian Ternamian,Renee Head,Nesrin Sabha,Robert W. Sobol,Michael D. Taylor,James T. Rutka,Chris Jones,Peter B. Dirks,Gelareh Zadeh,Cynthia Hawkins +20 more
TL;DR: Inhibition of ATM and MPG-mediated BER cooperate to sensitize tumor cells to alkylating agents, impairing tumor growth in vitro and in vivo with no toxicity to normal cells, providing an ideal therapeutic window.
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Genomics of medulloblastoma: from Giemsa-banding to next-generation sequencing in 20 years
TL;DR: The application of high-resolution microarray platforms to the study of medulloblastoma has revealed new oncogenes and tumor suppressors and has implicated changes in DNA copy number, gene expression, and methylation state in its etiology.