S
Shakti Gupta
Researcher at University of California, San Diego
Publications - 41
Citations - 2266
Shakti Gupta is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Immunity & Lipid metabolism. The author has an hindex of 19, co-authored 36 publications receiving 1590 citations. Previous affiliations of Shakti Gupta include Centers for Disease Control and Prevention & University of Florida.
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Journal ArticleDOI
Biomarkers of NAFLD progression: a lipidomics approach to an epidemic
D. Lee Gorden,David S. Myers,Pavlina T. Ivanova,Eoin Fahy,Mano Ram Maurya,Shakti Gupta,Jun Min,Nathanael J. Spann,Jeffrey G. McDonald,Samuel Kelly,Jingjing Duan,M. Cameron Sullards,Thomas J. Leiker,Robert M. Barkley,Oswald Quehenberger,Aaron M. Armando,Stephen B. Milne,Thomas P. Mathews,Michelle D. Armstrong,Chijun Li,Willie Melvin,Ronald H. Clements,M. Kay Washington,Alisha M. Mendonsa,Joseph L. Witztum,Ziqiang Guan,Christopher K. Glass,Robert C. Murphy,Edward A. Dennis,Alfred H. Merrill,David W. Russell,Shankar Subramaniam,H. Alex Brown +32 more
TL;DR: An “omics” approach to detecting a reproducible signature of lipid metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a double-blinded study of patients with different stages of NAFLD that involves profiling liver biopsies, plasma, and urine samples is described.
Journal ArticleDOI
A Mouse Macrophage Lipidome
Edward A. Dennis,Raymond A. Deems,Richard Harkewicz,Oswald Quehenberger,H. Alex Brown,Stephen B. Milne,David S. Myers,Christopher K. Glass,Gary Hardiman,Donna Reichart,Alfred H. Merrill,M. Cameron Sullards,Elaine Wang,Robert C. Murphy,Christian R. H. Raetz,Teresa A. Garrett,Ziqiang Guan,Andrea C. Ryan,David W. Russell,Jeffrey G. McDonald,Bonne M. Thompson,Walter A. Shaw,Manish Sud,Yihua Zhao,Shakti Gupta,Mano Ram Maurya,Eoin Fahy,Shankar Subramaniam +27 more
TL;DR: The lipidomic response of the murine macrophage RAW cell line to Kdo2-lipid A, the active component of an inflammatory lipopolysaccharide functioning as a selective TLR4 agonist and compactin, a statin inhibitor of cholesterol biosynthesis is reported.
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Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures
Helder I. Nakaya,Thomas Hagan,Sai Duraisingham,Eva K. Lee,Marcin Kwissa,Nadine Rouphael,Daniela Frasca,Merril Gersten,Aneesh K. Mehta,Renaud Gaujoux,Gui Mei Li,Shakti Gupta,Rafi Ahmed,Rafi Ahmed,Mark J. Mulligan,Shai S. Shen-Orr,Bonnie B. Blomberg,Shankar Subramaniam,Bali Pulendran,Bali Pulendran +19 more
TL;DR: These results identify shared vaccine-induced signatures across multiple seasons and in diverse populations and might help guide the development of next-generation vaccines that provide persistent immunity against influenza.
Journal ArticleDOI
Adjuvanting a subunit COVID-19 vaccine to induce protective immunity.
Prabhu S. Arunachalam,Alexandra C. Walls,Nadia A. Golden,Caroline Atyeo,Stephanie Fischinger,Chunfeng Li,Pyone P. Aye,Mary Jane Navarro,Lilin Lai,Venkata Viswanadh Edara,Katharina Röltgen,Kenneth A. Rogers,Lisa Shirreff,Douglas E. Ferrell,Samuel Wrenn,Deleah Pettie,John C. Kraft,Marcos C. Miranda,Elizabeth Kepl,Claire Sydeman,Natalie Brunette,Michael E. P. Murphy,Brooke Fiala,Lauren Carter,Alexander G. White,Meera Trisal,Ching-Lin Hsieh,Kasi E. Russell-Lodrigue,Christopher Monjure,Jason Dufour,Skye Spencer,Lara A. Doyle-Meyers,Rudolph Bohm,Nicholas J. Maness,Chad J. Roy,Jessica A. Plante,Kenneth S. Plante,Alex Lee Zhu,Matthew J. Gorman,Sally Shin,Xiaoying Shen,Jane Fontenot,Shakti Gupta,Derek T. O'Hagan,Robbert van der Most,Rino Rappuoli,Robert L. Coffman,David Novack,Jason S. McLellan,Shankar Subramaniam,David C. Montefiori,Scott D. Boyd,JoAnne L. Flynn,Galit Alter,Francois Villinger,Harry Kleanthous,Jay Rappaport,Mehul S. Suthar,Neil P. King,Neil P. King,David Veesler,Bali Pulendran +61 more
TL;DR: In this article, the authors demonstrate the capacity of a subunit vaccine, comprising the SARS-CoV-2 spike protein receptor-binding domain displayed on an I53-50 protein nanoparticle scaffold (hereafter designated RBD-NP), to stimulate robust and durable neutralizing-antibody responses.
Journal ArticleDOI
Bioinformatics and systems biology of the lipidome.
Shankar Subramaniam,Eoin Fahy,Shakti Gupta,Manish Sud,Robert W. Byrnes,Dawn Cotter,Ashok Reddy Dinasarapu,Mano Ram Maurya +7 more
TL;DR: A comprehensive summary of extant developments in lipid bioinformatics and systems biology is provided and the outlook for the future integration of lipidomics into cellular and organismic biology is discussed.