J
Jean Halbert
Researcher at University of Lausanne
Publications - 7
Citations - 663
Jean Halbert is an academic researcher from University of Lausanne. The author has contributed to research in topics: Y chromosome & Dosage compensation. The author has an hindex of 5, co-authored 7 publications receiving 405 citations. Previous affiliations of Jean Halbert include Ludwig Institute for Cancer Research.
Papers
More filters
Journal ArticleDOI
Gene expression across mammalian organ development
Margarida Cardoso-Moreira,Margarida Cardoso-Moreira,Jean Halbert,Delphine Valloton,Britta Velten,C. T. Chen,Yi Shao,Angélica Liechti,Kelly Ascencao,Coralie Rummel,Svetlana Ovchinnikova,Pavel V. Mazin,Pavel V. Mazin,Ioannis Xenarios,Keith Harshman,Matthew Mort,David Neil Cooper,Carmen Sandi,Michael J. Soares,Michael J. Soares,Paula G. Ferreira,Sandra Afonso,Miguel Carneiro,James M. A. Turner,John L. VandeBerg,Amir Fallahshahroudi,Per Jensen,R. Behr,Steven Lisgo,Susan Lindsay,Philipp Khaitovich,Philipp Khaitovich,Philipp Khaitovich,Wolfgang Huber,Julie C. Baker,Simon Anders,Yong Zhang,Henrik Kaessmann +37 more
TL;DR: It is found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase during development.
Journal ArticleDOI
Convergent origination of a Drosophila-like dosage compensation mechanism in a reptile lineage
Ray M. Marín,Diego Cortez,Francesco Lamanna,Madapura M. Pradeepa,Evgeny Leushkin,Philippe Julien,Angélica Liechti,Jean Halbert,Thoomke Brüning,Katharina Mössinger,Timo Trefzer,Christian Conrad,Halie N. Kerver,Juli Wade,Patrick Tschopp,Henrik Kaessmann +15 more
TL;DR: This work unveils the convergent emergence of a Drosophila-like dosage compensation mechanism in an ancient reptilian sex chromosome system and highlights that the evolutionary pressures imposed by sex chromosome dosage reductions in different amniotes were resolved in fundamentally different ways.
Journal ArticleDOI
Conserved microRNA editing in mammalian evolution, development and disease
Maria Warnefors,Maria Warnefors,Angélica Liechti,Jean Halbert,Delphine Valloton,Henrik Kaessmann,Henrik Kaessmann +6 more
TL;DR: The results show that site-specific miRNA editing is an evolutionarily conserved mechanism, which increases the functional diversity of mammalian miRNA transcriptomes and finds that although mi RNA editing is rare compared to editing of long RNAs, miRNAs are greatly overrepresented among conserved editing targets.
Journal ArticleDOI
Repurposing of promoters and enhancers during mammalian evolution
TL;DR: Evidence is provided that regulatory repurposing facilitated regulatory innovation and the origination of new genes and exons during evolution by detecting 445 regulatory elements with signatures of activity turnover (termed P/E elements).
Journal ArticleDOI
Sex-biased microRNA expression in mammals and birds reveals underlying regulatory mechanisms and a role in dosage compensation.
Maria Warnefors,Katharina Mössinger,Jean Halbert,Tania Studer,John L. VandeBerg,Isa Lindgren,Amir Fallahshahroudi,Per Jensen,Henrik Kaessmann +8 more
TL;DR: The authors' analyses uncovered numerous cases of somatic sex-biased miRNA expression, with the largest proportion found in the mouse heart and liver, and establish miRNA regulation as a novel gene-specific dosage compensation mechanism.