J
Jean-Louis Mandel
Researcher at University of Strasbourg
Publications - 372
Citations - 39716
Jean-Louis Mandel is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Gene & Fragile X syndrome. The author has an hindex of 101, co-authored 362 publications receiving 37522 citations. Previous affiliations of Jean-Louis Mandel include French Institute of Health and Medical Research & Collège de France.
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Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
Martin Hrabě de Angelis,George Nicholson,Mohammed Selloum,Jacqueline K. White,Hugh P. Morgan,Ramiro Ramirez-Solis,Tania Sorg,Sara Wells,Helmut Fuchs,Martin Fray,David J. Adams,Niels C. Adams,Thure Adler,Antonio Aguilar-Pimentel,Dalila Ali-Hadji,Gregory Amann,Philippe André,Sarah Atkins,Aurelie Auburtin,Abdel Ayadi,Julien Becker,Lore Becker,Elodie Bedu,Raffi Bekeredjian,Marie-Christine Birling,Andrew Blake,Joanna Bottomley,Michael R. Bowl,Véronique Brault,Dirk H. Busch,James Bussell,Julia Calzada-Wack,Heather Cater,Marie-France Champy,Philippe Charles,Claire Chevalier,Francesco Chiani,Gemma F. Codner,Roy Combe,Roger D. Cox,Emilie Dalloneau,André Dierich,Armida Di Fenza,Brendan Doe,Arnaud Duchon,Oliver Eickelberg,Christopher T. Esapa,Lahcen El Fertak,Tanja Feigel,Irina Emelyanova,Jeanne Estabel,Jack Favor,Ann M Flenniken,Alessia Gambadoro,Lilian Garrett,Hilary Gates,Anna-Karin Gerdin,George Gkoutos,Simon Greenaway,Lisa Glasl,Patrice Goetz,Isabelle Goncalves Da Cruz,Alexander Götz,Jochen Graw,Alain Guimond,Wolfgang Hans,Geoff Hicks,Sabine M. Hölter,Heinz Höfler,John M. Hancock,Robert Hoehndorf,Tertius Hough,Richard Houghton,Anja Hurt,Boris Ivandic,Hughes Jacobs,Sylvie Jacquot,Nora Jones,Natasha A. Karp,Hugo A. Katus,Sharon Kitchen,Tanja Klein-Rodewald,Martin Klingenspor,Thomas Klopstock,Valérie Lalanne,Sophie Leblanc,Christoph Lengger,Elise le Marchand,Tonia Ludwig,Aline Lux,Colin McKerlie,Holger Maier,Jean-Louis Mandel,Susan Marschall,Manuel Mark,David Melvin,Hamid Meziane,Kateryna Micklich,Christophe Mittelhauser,Laurent Monassier,David Moulaert,Stéphanie Muller,Beatrix Naton,Frauke Neff,Patrick M. Nolan,Lauryl M. J. Nutter,Markus Ollert,Guillaume Pavlovic,Natalia S. Pellegata,Emilie Peter,Benoit Petit-Demoulière,Amanda R. Pickard,Christine Podrini,Paul Potter,Laurent Pouilly,Oliver Puk,David S. Richardson,Stephane Rousseau,Leticia Quintanilla-Fend,Mohamed M. Quwailid,Ildiko Racz,Birgit Rathkolb,Fabrice Riet,Janet Rossant,Michel Roux,Jan Rozman,Edward Ryder,Jennifer Salisbury,Luis Santos,Karl-Heinz Schäble,Evelyn Schiller,Anja Schrewe,Holger Schulz,Ralf Steinkamp,Michelle Simon,Michelle Stewart,Claudia Stöger,Tobias Stöger,Minxuan Sun,David Sunter,Lydia Teboul,Isabelle Tilly,Glauco P. Tocchini-Valentini,Monica Tost,Irina Treise,Laurent Vasseur,Emilie Velot,Daniela Vogt-Weisenhorn,Christelle Wagner,Alison Walling,Marie Wattenhofer-Donzé,Bruno Weber,Olivia Wendling,Henrik Westerberg,Monja Willershäuser,Eckhard Wolf,Anne Wolter,Joe Wood,Wolfgang Wurst,Ali Önder Yildirim,Ramona Zeh,Andreas Zimmer,Annemarie Zimprich,Christopher Holmes,Karen P. Steel,Yann Herault,Valerie Gailus-Durner,Ann-Marie Mallon,Steve D.M. Brown +168 more
TL;DR: New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems.
Journal ArticleDOI
Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells.
Hélène Tronchère,Jocelyn Laporte,Caroline Pendaries,Claire Chaussade,Laurence Liaubet,Luciano Pirola,Jean-Louis Mandel,Bernard Payrastre +7 more
TL;DR: Data demonstrate for the first time a role for MTM1 in the production of PtdIns(5)P in mammalian cells, suggesting that the lack of transformation of phosphatidylinositol 3,5-bisphosphate into Ptdins(5), the function of which is still unknown, might be an important component in the etiology of myotubular myopathy.
Journal ArticleDOI
Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes
TL;DR: The fragile X mental retardation syndrome is caused by large methylated expansions of a CGG repeat in the FMR1 gene that lead to the loss of expression of FMRP, an RNA-binding protein this paper.
Journal ArticleDOI
The ovalbumin gene region: common features in the organisation of three genes expressed in chicken oviduct under hormonal control.
A. Royal,A. Garapin,B. Cami,F. Perrin,Jean-Louis Mandel,Marianne LeMeur,F. Brégégègre,Frank Gannon,J. P. LePennec,Pierre Chambon,Philippe Kourilsky +10 more
TL;DR: Two large DNA fragments overlapping the chicken ovalbumin gene have been isolated by molecular cloning and analysis of these fragments provided a map of a 46,000-base pair region of the chicken genome, suggesting that duplications have occurred in the ovalbumIn gene region in the course of evolution.
Journal ArticleDOI
A Novel RNA-binding Nuclear Protein That Interacts With the Fragile X Mental Retardation (FMR1) Protein
TL;DR: NUFIP mRNA expression is strikingly similar to that of the FMR1 gene in neurones of cortex, hippocampus and cerebellum and indicates a specific nuclear role for FMRP, which can shuttle between the nucleus and the cytoplasm.