Jessica A. Talamas

TL;DR: The complete genome sequence of an acetate-utilizing methanogen, Methanosarcina acetivorans C2A, is reported, which indicates the likelihood of undiscovered natural energy sources for methanogenesis, whereas the presence of single-subunit carbon monoxide dehydrogenases raises the possibility of nonmethanogenic growth.

TL;DR: It is shown via RNAi-mediated knockdown that ELYS, a nucleoporin critical for the recruitment of the essential Nup107/160 complex to chromatin, is required for NPC assembly at the end of mitosis but not during interphase, and that the transmembrane nucleiporin POM121 is criticalfor the incorporation of the Nup 107/160complex into new assembly sites specifically during inter phase.

TL;DR: POM121 and Sun1, but not the Nup107–160 complex, are required for fusion of the inner and outer nuclear membrane during nuclear pore assembly in interphase of the cell cycle.

TL;DR: The presence of multiple Nups at promoters, enhancers, and insulators in the Drosophila genome is identified and a functional role for Nup98 is uncovered in mediating enhancer-promoter looping at ecdysone-inducible genes.

TL;DR: This investigation uncovered differential binding of these NPC subunits, where Nup107 preferentially targets active genes while Nup93 associates primarily with Polycomb-silenced regions, and lend to a model where different nuclear pores bind different types of chromatin via interactions with specific NPC sub-complexes, and a subset of Polycomb domains is stabilized by interactions with N up93.